and Human Services (HHS)
EXPIRED
Department
of Health and Human Services
Participating
Organizations
National Institutes of Health (NIH), (http://www.nih.gov/)
Components of Participating Organizations
National
Institute of General Medical Sciences (NIGMS), (http://www.nigms.nih.gov/)
National Cancer Institute (NCI), (http://www.nci.nih.gov/)
National Heart, Lung, and Blood
Institute (NHLBI), (http://www.nhlib.nih.gov/)
National Human Genome Research Institute (NHGRI),
(http://www.genome.gov/)
National Institute on Aging (NIA),
(http://www.nia.nih.gov/)
National Institute on Alcohol
Abuse and Alcoholism (NIAAA), (http://www.niaaa.nih.gov/)
National Institute of Allergy and Infectious Diseases
(NIAID), (http://www.niaid.nih.gov)
National Institute of Arthritis and Musculoskeletal and
Skin Diseases (NIAMS), (http://www.niams.nih.gov/)
National Institute of Biomedical Imaging and Bioengineering
(NIBIB), (http://www.nibib.nih.gov/)
National Institute on Deafness and Other Communication
Disorders (NIDCD), (http://www.nidcd.nih.gov/)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), (http://www.niddk.nih.gov/)
National Institute on Drug Abuse (NIDA),
(http://www.nida.nih.gov/)
National Institute of Dental and Craniofacial Research
(NIDCR), (http://www.nidr.nih.gov/)
National Institute of Environmental Health Sciences (NIEHS), (http://www.niehs.nih.gov/)
National Institute of Mental Health (NIMH),
(http://www.nimh.nih.gov/)
National Institute of Neurological Disorders and Stroke
(NINDS), (http://www.ninds.nih.gov/)
National Library of Medicine (NLM), (http://www.nlm.nih.gov/)
Title: Innovations
in Biomedical Computational Science and Technology (R01)
Announcement Type
This is a
conversion/reissuance of PAR-06-410, previously
issued May 15, 2006.
Update: The following update relating to this announcement has been issued:
NOTICE: Applications submitted in response to this Funding Opportunity Announcement (FOA) for Federal assistance must be submitted electronically through Grants.gov (http://www.grants.gov) using the SF424 Research and Related (R&R) forms and the SF424 (R&R) Application Guide
APPLICATIONS MAY NOT BE SUBMITTED IN PAPER FORMAT.
This FOA must be read in conjunction with the application guidelines included with this announcement in Grants.gov/Apply for Grants (hereafter called Grants.gov/Apply).
A registration process is necessary before submission and applicants are highly encouraged to start the process at least four weeks prior to the grant submission date. See Section IV.
Program Announcement (PA) Number: PAR-07-344
Catalog of Federal
Domestic Assistance Number(s)
93.286,
93.279, 93.309, 93.859, 93.821, 93.862, 93.396, 93.394, 93.121, 93.242, 93.853,
93.279, 93.879, 93.233, 93.837, 93.838, 93.839,
93.392, 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399, 93.113, 93.114
Key Dates (Revised per NOT-GM-07-115) Key Dates (Original Dates Superseded by Dates Above) Additional
Overview Content Table
of Contents Part I Overview Information Section I. Funding Opportunity Description 1. Research Objectives The
Institutes and Centers of the NIH acknowledge the wisdom of this recommendation
and offer support through the current solicitation for fundamental research in
biomedical information science and technology as well as for the development of
new informatics, computational and mathematical tools
and technologies. BISTI targets support for fundamental research in biomedical
computing science and technology as well as the development and application of
new biocomputing tools or technologies for a particular
area(s) of scientific opportunity in biomedical research. Programs may
target one or multiple areas of biomedical computing that will enable progress
in biomedical research. Examples of data types that could be considered
include but are not limited to genomic sequences,
biomedical images, qualitative descriptors for health and social science,
remote sensing and geospatial images, and pathway data. Specific research
areas solicited in informatics or computational science include but are not
limited to research, development and application of: Particular
research activities related to the formalization of
data-related concepts are appropriate under this announcement. An overall goal
of this announcement is to support research and development of tools and
approaches for computing on data; most of these will likely be implemented in software. Best practices for such endeavors
include the explicit formalization of data-related concepts that pertain
directly to the software. This would include activities such as: 1) assessing
data flow and use; 2) defining the terms used for
data, fields, operations, etc.; 3) defining the relationships among terms and
functions; 4) defining data models and schemas; and 5) other similar
activities. It is important to emphasize that these activities are appropriate
as they relate closely to the particular software
itself, or to making the particular software interoperable with other specific
software or computational resources. Areas of
biomedical research likely to be critically dependent on biocomputing advances
include but are not limited to: Projects
must span the interface of biomedical research and biomedical computational
science and technology. Applicants will be expected to demonstrate fundamental
understanding and adequate expertise in both the relevant areas of computational science and technology and biomedical research.
Cross-disciplinary collaborations are strongly encouraged, including those
which have been initiated or fostered through other cross-cutting initiatives,
and now are seeking independent support. Given the expanding needs in biomedical research for advances in a
variety of areas of information science and technology, the approaches and
technologies proposed under this announcement should ultimately be
generalizable, scalable, extensible, and interoperable. The projects should take into account the needs of the biomedical
research community that will be the ultimate end users of the products of the
research. The projects should also address plans for ensuring the
dissemination of useful products of the research,
including approaches, technologies and tools, to the relevant research and user
communities. The informatics and computational research proposed should be
future-oriented, fill an area of need or projected need, and seek to exceed the
current state of the art. Some NIH
institutes and centers may have other grant mechanisms that could apply to
biomedical computing projects. Interested participants should contact the
institute or center technical contact indicated in the
"NIH BISTI contacts" located at the URL given in the section VIII.1 of the
announcement. Through
separate program announcements, the participating Institutes and Centers of the
NIH invite applications for SBIR and STTR support focusing on the similar
research areas as described above. Applicants
are encouraged to visit the BISTI web site for SBIR/STTR and other relevant
funding opportunities http://www.bisti.nih.gov/bistic_funding.cfm. See Section VIII, Other Information
- Required Federal Citations, for policies related
to this announcement. 1. Mechanism of Support The
applicant will be solely responsible for planning, directing, and executing the
proposed project. This FOA uses Just-in-Time information
concepts. It also uses the modular as well as the
non-modular budget formats (see http://grants.nih.gov/grants/funding/modular/modular.htm). Specifically, if you are a U.S. organization
and are submitting an application with direct costs in each year of $250,000 or
less (excluding consortium
Facilities and Administrative [F&A] costs), use the PHS398 Modular Budget
component provided in the SF424 (R&R) Application Package and SF424
(R&R) Application Guide (see specifically Section 5.4, Modular Budget
Component, of the Application Guide). U.S. applicants requesting more than $250,000 in annual direct costs and all foreign
applicants must complete and submit budget requests using the Research &
Related Budget component found in the application package for this FOA. See NOT-OD-06-096,
August 23, 2006. 2.
Funds Available NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made
in response to this FOA. F&A costs requested by consortium participants are not
included in the direct cost limitation. See NOT-OD-05-004,
November 2, 2004. 1. Eligible Applicants 1.B.
Eligible Individuals Any individual(s) with the
skills, knowledge, and resources necessary to carry out the proposed research
as the PD/PI is invited to work with his/her organization to develop an
application for support. Individuals from underrepresented racial and ethnic
groups as well as individuals with disabilities are always encouraged to apply
for NIH support. More than one PD/PI, or
multiple PDs/PIs, may be designated on the application for projects that
require a team science approach that clearly does not fit the single-PD/PI
model. Additional information
on the implementation plans and policies and procedures to formally allow more
than one PD/PI on individual research projects is available at http://grants.nih.gov/grants/multi_pi. All PDs/PIs must be registered in the NIH eRA Commons prior to the submission of the application (see http://era.nih.gov/ElectronicReceipt/preparing.htm for instructions). The decision of whether to
apply for a single PD/PI or multiple PD/PI grant is the responsibility of the
investigators and applicant organizations and should be determined by the
scientific goals of the project. Applications for multiple PD/PI grants will
require additional information, as outlined in the instructions below. The NIH
review criteria for approach, investigators, and environment have been modified
to accommodate applications involving either a single PD/PI or multiple
PDs/PIs. When considering multiple PDs/PIs, please be aware that the structure
and governance of the PD/PI leadership team as well as the knowledge, skills
and experience of the individual PD/PIs will be factored into the assessment of
the overall scientific merit of the application. Multiple PDs/PIs on a project
share the authority and responsibility for leading and directing the project,
intellectually and logistically. Each PD/PI is responsible and accountable
to the grantee organization, or, as appropriate, to a collaborating
organization, for the proper conduct of the project or program, including the
submission of required reports. For further information on multiple PDs/PIs,
please see http://grants.nih.gov/grants/multi_pi. 2.
Cost Sharing or Matching Applicants may submit
more than one application, provided each application is scientifically
distinct. Section IV. Application and Submission Information To download a SF424
(R&R) Application Package and SF424 (R&R) Application Guide for
completing the SF424 (R&R) forms for this FOA, link to http://www.grants.gov/applicants/apply_for_grants.jsp and follow the directions provided on that Web site. PDs/PIs should work
with their institutions/organizations to make sure they are registered in the
eRA Commons. Several additional
separate actions are required before an applicant institution/organization can
submit an electronic application, as follows: 1)
Organizational/Institutional Registration in Grants.gov/Get Registered 2) Organizational/Institutional
Registration in the eRA Commons 3) Project Director/Principal
Investigator (PD/PI) Registration in the NIH eRA Commons: Refer to the NIH eRA Commons System (COM)
Users Guide. Both the PD/PI(s) and
AOR/SO need separate accounts in the NIH eRA Commons since both are authorized
to view the application image. Note that if a PD/PI is
also an NIH peer-reviewer with an Individual DUNS and CCR registration, that
particular DUNS number and CCR registration are for the individual reviewer
only. These are different than any DUNS number and CCR registration used by an
applicant organization. Individual DUNS and CCR registration should be used
only for the purposes of personal reimbursement and should not be used on any
grant applications submitted to the Federal Government. Several of the steps of
the registration process could take four weeks or more. Therefore, applicants
should immediately check with their business official to determine whether
their organization/institution is already registered in both Grants.gov and the Commons. The NIH will accept
electronic applications only from organizations that have completed all
necessary registrations. 1. Request Application Information Note:
Only the forms package directly attached to a specific FOA can be used. You
will not be able to use any other SF424 (R&R) forms (e.g., sample forms,
forms from another FOA), although some of the "Attachment" files may
be useable for more than one FOA. 2.
Content and Form of Application Submission Prepare all
applications using the SF424 (R&R) application forms and in accordance with
the SF424 (R&R) Application Guide for this FOA
through Grants.gov/Apply. The SF424 (R&R)
Application Guide is critical to submitting a complete and accurate application
to NIH. There are fields within the SF424 (R&R) application components
that, although not marked as mandatory, are required by NIH (e.g., the
Credential log-in field of the Research & Related Senior/Key Person
Profile component must contain the PD/PI’s assigned eRA Commons User ID).
Agency-specific instructions for such fields are clearly identified in the
Application Guide. For additional information, see Frequently Asked Questions
Application Guide, Electronic
Submission of Grant Applications. The SF424 (R&R)
application has several components. Some components are required, others are
optional. The forms package associated with this FOA in Grants.gov/APPLY includes all applicable components, required and optional. A completed
application in response to this FOA includes the data in the following
components: Required Components: Foreign
Organizations Non-domestic (non-U.S.) Entity) Applications from foreign
organizations must: Proposed
research should provide special opportunities for furthering research programs
through the use of unusual talent, resources, populations, or environmental
conditions in other countries that are not readily available in the United States or that augment existing U.S. resources. SPECIAL
INSTRUCTIONS Applications with
Multiple PDs/PIs When multiple PDs/PIs are
proposed, NIH requires one PD/PI to be designated as the "Contact PI, who
will be responsible for all communication between the PDs/PIs and the NIH, for
assembling the application materials outlined below, and for coordinating
progress reports for the project. The contact PD/PI must meet all eligibility
requirements for PD/PI status in the same way as other PDs/PIs, but has no
other special roles or responsibilities within the project team beyond those
mentioned above. Information for the Contact
PD/PI should be entered in item 15 of the SF424 (R&R) Cover
component. All other PDs/PIs should be listed in the Research &
Related Senior/Key Person component and assigned the project role of
PD/PI. Please remember that all PDs/PIs must be registered in the eRA Commons prior to application submission. The Commons ID of each PD/PI must be included in the Credential field of the Research &
Related Senior/Key Person component. Failure to include this data field
will cause the application to be rejected. All projects proposing Multiple PDs/PIs will be
required to include a new section describing the leadership of the project. Multiple PD/PI Leadership Plan: For applications designating
multiple PDs/PIs, a new section of the research plan, entitled Multiple PD/PI
Leadership Plan (Section 14 of the Research Plan Component in the SF424
(R&R)), must be included. A rationale for choosing a multiple PD/PI
approach should be described. The governance and organizational structure of
the leadership team and the research project should be described, including
communication plans, process for making decisions on scientific direction, and
procedures for resolving conflicts. The roles and administrative,
technical, and scientific responsibilities for the project or program should be
delineated for the PDs/PIs and other collaborators. If budget allocation
is planned, the distribution of resources to specific components of the project
or the individual PDs/PIs should be delineated in the Leadership Plan. In the
event of an award, the requested allocations may be reflected in a footnote on
the Notice of Award. Applications Involving a Single Institution When all PDs/PIs are
within a single institution, follow the instructions contained in the SF424
(R&R) Application Guide. Applications Involving Multiple Institutions When multiple institutions
are involved, one institution must be designated as the prime institution and
funding for the other institution(s) must be requested via a subcontract to be
administered by the prime institution. When submitting a detailed budget, the
prime institution should submit its budget using the Research & Related
Budget component. All other institutions should have their individual
budgets attached separately to the Research & Related Subaward Budget
Attachment(s) Form. See Section 4.8 of the SF424 (R&R) Application Guide
for further instruction regarding the use of the subaward budget form. When submitting a modular
budget, the prime institution completes the PHS398 Modular Budget component
only. Information concerning the consortium/subcontract budget is provided
in the budget justification. Separate budgets for each consortium/subcontract
grantee are not required when using the Modular budget format. See Section 5.4
of the Application Guide for further instruction regarding the use of the
PHS398 Modular Budget component. 3.
Submission Dates and Times 3.A.1. Letter of Intent A
letter of intent is not required for the funding opportunity. 3.B. Submitting an Application Electronically to the
NIH 3.C.
Application Processing Once an application
package has been successfully submitted through Grants.gov, any errors have
been addressed, and the assembled application has been created in the eRA Commons, the PD/PI and the Authorized Organization Representative/Signing Official (AOR/SO) have
two business days to view the application image. Upon receipt, applications will be evaluated for
completeness by the CSR and responsiveness by the components
of the participating organizations. Incomplete and non-responsive
applications will not be reviewed. Note: Since email can be unreliable, it is the
responsibility of the applicant to check periodically on their application
status in the Commons. The
NIH will not accept any application in response to this FOA that is essentially
the same as one currently pending initial merit review unless the applicant
withdraws the pending application. The NIH will not accept any application that
is essentially the same as one already reviewed. This does not preclude the
submission of an application already reviewed with substantial changes, but
such application must include an Introduction addressing the previous
critique. Note such an application is considered a "resubmission" for
the SF424 (R&R). 4. Intergovernmental Review Pre-award costs are allowable.
A grantee may, at its own risk and without NIH prior approval, incur
obligations and expenditures to cover costs up to 90 days before the beginning
date of the initial budget period of a new or competing renewal (formerly
competing continuation ) award if such costs: are necessary to conduct the
project, and would be allowable under the grant, if awarded, without NIH prior
approval. If specific expenditures would otherwise require prior approval, the
grantee must obtain NIH approval before incurring the cost. NIH prior approval
is required for any costs to be incurred more than 90 days before the beginning
date of the initial budget period of a new or competing renewal award. 6. Other Submission
Requirements The
NIH requires the PD/PI(s) to fill in his/her Commons User ID in the PROFILE
Project Director/Principal Investigator section, Credential log-in field of
the Research & Related Senior/Key Person Profile component. Organizational DUNS The
applicant organization must include its DUNS number in its Organization Profile
in the eRA Commons. This DUNS number must match the DUNS number provided at CCR
registration with Grants.gov. For
additional information, see Frequently Asked Questions Application Guide, Electronic
Submission of Grant Applications. PHS398 Research Plan Component Sections Items
2-5 of the PHS398 Research Plan component are limited to 25 pages. While each
section of the Research Plan component needs to be uploaded separately as a PDF
attachment, applicants are encouraged to construct the Research Plan component
as a single document, separating sections into distinct PDF attachments just
before uploading the files. This approach will enable applicants to better
monitor formatting requirements such as page limits. All attachments must be
provided to NIH in PDF format, filenames must be included with no spaces or
special characters, and a .pdf extension must be used. All
application instructions outlined in the SF424 (R&R) Application Guide are
to be followed, incorporating "Just-in-Time" information concepts,
and with the following additional requirements: Special Instructions
for Modular Grant applications R01
applications from U.S. institutions/organizations requesting up to $250,000 per
year in direct costs (excluding consortium F&A costs) must be submitted in
a modular budget format. Additional information on modular budgets is available
at http://grants.nih.gov/grants/funding/modular/modular.htm. When
submitting a modular budget, the applicant organization will include only the
PHS398 Modular Budget component. See Section 5.4 of the SF424 (R&R) Application Guide for further
instructions regarding the use of the PHS398 Modular Budget component. Foreign organizations
may not submit modular budgets. See NOT-OD-06-096. Special Instructions for Applications Requesting
$500,000 (direct costs) or More Per Year Applicants
requesting $500,000 or more in direct costs for any year (excluding consortium
F&A costs) must carry out the following steps: 2)
Obtain agreement from the IC staff that the IC will accept your application for
consideration for award; and, This policy applies to
all new applications, competing renewal (formerly competing continuation )
applications, resubmission (formerly revised/amended ) applications, and
revision (formerly competing supplemental ) applications. See NOT-OD-02-004,
October 16, 2001. Appendix
Materials NIH has published new limitations on grant application
appendix materials to encourage applications to be as concise as possible while
containing the information needed for expert scientific review. See
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-018.html. Applicants must follow the specific
instructions on Appendix materials as described in the SF424 (R&R) Application Guide
(See http://grants.nih.gov/grants/funding/424/index.htm). Do not use the Appendix to circumvent the page limitations of
the Research Plan component. An application that does not observe the required
page limitations may be delayed in the review process. Note:
While each section of the PHS398 Research Plan component needs to be uploaded
separately as a PDF attachment, applicants are encouraged to construct the
Research Plan component as a single document, separating sections into distinct
PDF attachments just before uploading the files. This approach will enable
applicants to monitor better formatting requirements such as page limits. All
attachments must be provided to NIH in PDF format, filenames must be included
with no spaces or special characters, and a .pdf extension must be used. Foreign Applications (Non-domestic (non-U.S.) Entity) Plan for Sharing Research Data The
precise content of the data-sharing plan will vary, depending on the data being
collected and how the investigator is planning to share the data. Applicants
who are planning to share data may wish to describe briefly the expected
schedule for data sharing, the format of the final dataset, the documentation
to be provided, whether or not any analytic tools also will be provided,
whether or not a data-sharing agreement will be required and, if so, a brief
description of such an agreement (including the criteria for deciding who can
receive the data and whether or not any conditions will be placed on their
use), and the mode of data sharing (e.g., under their own auspices by mailing a
disk or posting data on their institutional or personal Web site, through a
data archive or enclave). Investigators choosing to share under their own
auspices may wish to enter into a data-sharing agreement. References to data
sharing may also be appropriate in other sections of the application. NIH
policy expects that grant recipients make unique research resources readily
available for research purposes to qualified individuals within the scientific
community after publication (See the NIH Grants Policy Statement http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part7.htm#_Toc54600131).
Investigators responding to this funding opportunity should include a sharing
research resources plan addressing how unique research resources will be shared
or explain why sharing is not possible. Plan for Sharing Software A software dissemination plan,
with appropriate timelines, must be included in the application. This should be
included in a separate heading in the Research Design and Methods section.
There is no prescribed single license for software produced through grants responding to this announcement. However, NIH does have
goals for software dissemination, and reviewers will be instructed to evaluate
the dissemination plan relative to these goals: 1. The software should be freely available to biomedical
researchers and educators in the non-profit sector,
such as institutions of education, research institutions, and government
laboratories. 2. The terms of software availability should permit the
commercialization of enhanced or customized versions of the software, or incorporation of the software or pieces of it into
other software packages. 3. To preserve utility to the community, the software
should be transferable such that another individual or team can continue
development in the event that the original investigators
are unwilling or unable to do so. 4. The terms of software availability should include the
ability of researchers to modify the source code and to share modifications
with other colleagues. An applicant should take responsibility for creating the original and subsequent official versions of a piece
of software, and should provide a plan to manage the dissemination or adoption
of improvements or customizations of that software by others. This plan should
include a method to distribute other user's
contributions such as extensions, compatible modules, or plug-ins. Section
V. Application Review Information 1.
Criteria (Update: Enhanced review criteria have been issued for the evaluation of research applications received for potential FY2010 funding and thereafter - see NOT-OD-09-025). Only the review
criteria described below will be considered in the review process. 2.
Review and Selection Process Applications
submitted in response to this funding opportunity will compete for available
funds with all other recommended applications. The following will be considered
in making funding decisions: The goals of NIH
supported research are to advance our understanding of biological systems, to
improve the control of disease, and to enhance health. In their written
critiques, reviewers will be asked to comment on each of the following criteria
in order to judge the likelihood that the proposed research will have a
substantial impact on the pursuit of these goals. Each of these criteria will
be addressed and considered in assigning the overall score, weighting them as
appropriate for each application. Note that an
application does not need to be strong in all categories to be judged likely to
have major scientific impact and thus deserve a high priority score. For
example, an investigator may propose to carry out important work that by its
nature is not innovative but is essential to move a field forward. Innovation: Is the project
original and innovative? For example: Does the project challenge existing
paradigms or clinical practice; address an innovative hypothesis or critical
barrier to progress in the field? Does the project develop or employ novel
concepts, approaches, methodologies, tools, or technologies for this area? Investigators: Are the PD/PI(s)
and other key personnel appropriately trained and well suited to carry out this
work? Is the work proposed appropriate to the experience level of the principal
investigator and other researchers? Does the PD/PI(s) and investigative team
bring complementary and integrated expertise to the project (if applicable)? 2.A.
Additional Review Criteria Resubmission Applications (formerly
revised/amended applications): Are the responses to comments from the
previous scientific review group adequate? Are the improvements in the
resubmission application appropriate? Protection
of Human Subjects from Research Risk: The involvement of human
subjects and protections from research risk relating to their participation in
the proposed research will be assessed. See the Human Subjects Sections
of the PHS398 Research Plan component of the SF424 (R&R).. 2.B. Additional Review Considerations Applications from Foreign Organizations: Whether
the project presents special opportunities for furthering research programs
through the use of unusual talent, resources, populations, or environmental
conditions in other countries that are not readily available in the United States or that augment existing U.S. resources will be assessed. 2.C.
Sharing Research Data The adequacy of
the resources sharing plan and any related data sharing plans will be
considered by Program staff of the funding organization when making
recommendations about funding applications. The effectiveness of the resource
sharing will be evaluated as part of the administrative review of each Non-Competing Grant
Progress Report (PHS 2590), See Section VI.3.,
Reporting. Model Organism Sharing Plan: Reviewers are
asked to assess the sharing plan in an administrative note. The sharing plan
itself should be discussed after the application is scored. Whether a sharing
plan is reasonable can be determined by the reviewers on a case-by-case basis,
taking into consideration the organism, the timeline, the applicant's decision
to distribute the resource or deposit it in a repository, and other relevant
considerations. 3.
Anticipated Announcement and Award Dates 1.
Award Notices If
the application is under consideration for funding, NIH will request
"just-in-time" information from the applicant. For details,
applicants may refer to the NIH
Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards,
Subpart A: General. 3.
Reporting We
encourage your inquiries concerning this funding opportunity and welcome the
opportunity to answer questions from potential applicants. Inquiries may fall
into three areas: scientific/research, peer review, and financial or grants
management issues: Please direct Institute- or domain-specific issues should
be directed to the NIH BISTI contacts listed at the following Web site: http://www.bisti.nih.gov/R01-contacts.cfm These scientific contacts must also be used to obtain
permission to submit applications that request more the $500,000 of direct
costs in any year. Peter Lyster, Ph.D. 2. Peer Review Contact(s): Direct your questions about peer review issues to: George Chacko, Ph.D. 3. Financial/Grants Management
Contact(s): Section VIII. Other Information Required Federal
Citations Use of Animals in
Research: Sharing Research Data: Access
to Research Data through the Freedom of Information Act: Healthy
People 2010:
Release/Posted
Date: March 29, 2007
Opening Date: April 2, 2007 (Earliest date
an application may be submitted to Grants.gov)
Letters of Intent Receipt Date(s): Not applicable
NOTE: On time submission requires that
applications be successfully submitted to Grants.gov no later than 5:00 p.m.
local time (of the applicant institution/organization).
Application Submission/Receipt Date(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm
Peer Review Date(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Council Review Date(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Earliest Anticipated Start Date(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm#reviewandaward
Additional Information To Be Available Date (URL Activation Date): Not Applicable
Expiration
Date: New Date September 8, 2009 per NOT-GM-09-021; Original Date: May 8, 2009
Release/Posted
Date: March 29, 2007
Opening Date: April 2, 2007 (Earliest date
an application may be submitted to Grants.gov)
Letters of Intent Receipt Date(s): Not applicable
NOTE: On time submission requires that
applications be successfully submitted to Grants.gov no later than 5:00 p.m.
local time (of the applicant institution/organization).
Application Submission/Receipt Date(s): (No longer apply see above) May 24, 2007; September 24, 2007; January 24, 2008; May 24,
2008; September 24, 2008, January 24, 2009
Peer Review Date(s): October-November
2007; February-March, 2008; June-July 2008; October-November, 2008;
February-March, 2009; June-July, 2009
Council Review Date(s): January, 2008; May, 2008; October,
2008; January, 2009; May, 2009; October
2009
Earliest Anticipated Start
Date(s): April, 2008; July, 2008;
December, 2008; April, 2009; July 2009, December, 2009
Additional Information To Be Available
Date (Activation Date): Not Applicable
Expiration
Date: May 8, 2009
Due Dates for E.O. 12372
Not Applicable
Executive Summary
Part II Full Text of Announcement
Section I. Funding Opportunity
Description
1. Research Objectives
Section II. Award Information
1. Mechanism of Support
2. Funds Available
Section III. Eligibility Information
1. Eligible Applicants
A. Eligible Institutions
B. Eligible Individuals
2. Cost Sharing or Matching
3. Other-Special Eligibility Criteria
Section
IV. Application and Submission Information
1. Request Application Information
2. Content and Form of Application Submission
3. Submission Dates and Times
A. Submission, Review, and
Anticipated Start Dates
1. Letter of Intent
B. Submitting an Application
Electronically to the NIH
C. Application Processing
4. Intergovernmental Review
5. Funding Restrictions
6. Other Submission Requirements
Section V. Application Review Information
1. Criteria
2. Review and Selection Process
A. Additional Review Criteria
B. Additional Review Considerations
C. Sharing Research Data
D. Sharing Research Resources
3. Anticipated Announcement and Award Dates
Section VI. Award Administration
Information
1. Award Notices
2. Administrative and National Policy Requirements
3. Reporting
Section VII. Agency Contacts
1. Scientific/Research Contact(s)
2. Peer Review Contact(s)
3. Financial/Grants Management Contact(s)
Section VIII. Other Information
- Required Federal Citations
Part II
- Full Text of Announcement
Computing
and computational tools have become increasingly important
in enabling progress in biomedical research. In recognition of the critical
role computing and computer science plays in biomedical research, the NIH
Director commissioned a Working Group on Biomedical Computing in June 1999.
The result of the deliberations of the Working Group
on Biomedical Computing was a report entitled "The Biomedical Information
Science and Technology Initiative (BISTI)" which can be accessed at the
following site: http://www.nih.gov/welcome/director/060399.htm. A major
recommendation of the BISTI is that the NIH should provide additional resources
and incentives for basic research to provide adequate support for those who are
inventing, refining, and applying the tools of
biomedical computing. The promotion of the interface of biomedical information
science and technology with biomedical research should result in new digital
and electronic tools that will have substantial impact on broad areas of
biomedical research.
Section
II. Award Information
This Funding
Opportunity Announcement (FOA) will use the NIH Research Project Grant (R01) award mechanism.
Because the nature and scope
of the proposed research will vary from application to application, it is
anticipated that the size and duration of each award will also vary. Although
the financial plans of the Institutes and Centers (ICs) provide support for
this program, awards pursuant to this funding opportunity are contingent upon
the availability of funds and the submission of a sufficient number of
meritorious applications.
Section
III. Eligibility Information
1.A. Eligible
Institutions
You may submit an
application(s) if your institution/organization has any of the following
characteristics:
This program does not require cost
sharing as defined in the current NIH
Grants Policy Statement.
3. Other-Special
Eligibility Criteria
At this
time, it is anticipated that this FOA will be reissued. Competing renewal
(formerly competing continuation ) applications will be accepted at the
receipt dates of this and subsequent reissuances.
A one-time registration is required for institutions/organizations at both:
Grants.gov Customer
Support
Contact Center Phone: 800-518-4726
Business Hours: M-F 7:00 a.m. - 9:00 p.m. Eastern Time
Email [email protected]
eRA Commons Help Desk
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
TTY: 301-451-5939
Business hours M-F 7:00 a.m. 8:00 p.m. Eastern Time
Email [email protected]
Applicants must
download the SF424 (R&R) application forms and the SF424 (R&R)
Application Guide for this FOA through Grants.gov/Apply.
For further assistance, contact GrantsInfo: Telephone
301-710-0267, Email: [email protected].
Telecommunications for the hearing impaired: TTY
301-451-5936.
SF424 (R&R) (Cover component)
Research & Related Project/Performance Site Locations
Research & Related Other Project Information
Research & Related Senior/Key Person
PHS398 Cover Page Supplement
PHS398 Research Plan
PHS398 Checklist
PHS398 Modular Budget or Research & Related Budget,
as appropriate (See Section IV.6., Special Instructions, regarding appropriate
required budget component.)
Research
& Related Budget (required for foreign applications)
Optional Components:
PHS398 Cover Letter File
Research & Related Subaward Budget Attachment(s) Form
NIH policies concerning grants to
foreign (non-U.S.) organizations can be found in the NIH Grants Policy
Statement at: http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part12.htm#_Toc54600260.
See Section IV.3.A. for details.
3.A.
Submission, Review, and Anticipated Start Dates
Opening Date: April 2, 2007 (Earliest date an
application may be submitted to Grants.gov)
Letters of Intent Receipt Date(s): Not applicable
Application
Submission/Receipt Date(s): May 24, 2007; September 24, 2007; January 24, 2008;
May 24, 2008; September 24, 2008, January 24, 2009
Peer
Review Date(s): October-November 2007; February-March, 2008;
June-July 2008; October-November, 2008; February-March, 2009; June-July, 2009
Council
Review Date(s): January, 2008;
May, 2008; October 2008; January, 2009; May, 2009; October, 2009
Earliest
Anticipated Start Date(s): April, 2008; July, 2008; December, 2008; April, 2009; July
2009, December, 2009
To submit an application in response to this
FOA, applicants should access this FOA via http://www.grants.gov/applicants/apply_for_grants.jsp
and follow steps 1-4. Note: Applications must only be submitted
electronically. PAPER APPLICATIONS WILL NOT BE ACCEPTED.
Applications may be submitted on or after the opening date and must be
successfully received by Grants.gov no later than 5:00 p.m. local time (of the applicant
institution/organization) on the application submission/receipt date(s). (See Section IV.3.A. for all dates.) If an application is not submitted by the receipt
date(s) and time, the application may be delayed in the review process or not
reviewed.
There will
be an acknowledgement of receipt of applications from Grants.gov and the Commons. The submitting AOR receives
the Grants.gov acknowledgments. The AOR and the PI receive Commons
acknowledgments. Information related to the assignment of an application to a
Scientific Review Group is also in the Commons.
This initiative is not
subject to intergovernmental
review.
5.
Funding Restrictions
All NIH awards are
subject to the terms and conditions, cost principles, and other considerations
described in the NIH Grants
Policy Statement.
The incurrence of pre-award costs in anticipation of a competing or
non-competing award imposes no obligation on NIH either to make the award or to
increase the amount of the approved budget if an award is made for less than
the amount anticipated and is inadequate to cover the pre-award costs incurred.
NIH expects the grantee to be fully aware that pre-award costs result in
borrowing against future support and that such borrowing must not impair the
grantee's ability to accomplish the project objectives in the approved time
frame or in any way adversely affect the conduct of the project. See the NIH Grants
Policy Statement.
PD/PI Credential (e.g., Agency Login)
1) Contact the
IC program staff at least 6 weeks before submitting the application, i.e., as
you are developing plans for the study;
3) Include
the PHS398 Cover Letter component with the application to identify the staff
member and IC who agreed to accept assignment of the application.
All applicants must include a plan for sharing
research data in their application. The data sharing policy is available at http://grants.nih.gov/grants/policy/data_sharing.
All investigators responding to this funding opportunity should include a
description of how final research data will be shared, or explain why data
sharing is not possible.
The reasonableness of the data sharing plan or the rationale for not sharing
research data will be assessed by the reviewers. However, reviewers will not
factor the proposed data sharing plan into the determination of scientific
merit or the priority score.
Sharing
Research Resources
The adequacy of the resources sharing plan and any
related data sharing plans will be considered by Program staff of the funding
organization when making recommendations about funding applications. The
effectiveness of the resource sharing will be evaluated as part of the
administrative review of each Non-Competing Grant
Progress Report (PHS 2590). See Section VI.3.,
Reporting.
Applications
submitted for this funding opportunity will be assigned to the ICs on the basis
of established PHS referral guidelines.
Appropriate scientific review groups convened in
accordance with the standard NIH peer review procedures (http://www.csr.nih.gov/refrev.htm)
will evaluate applications for scientific and technical merit.
As part of the initial merit review, all applications
will:
Significance: Does this study address an important problem? If
the aims of the application are achieved, how will scientific knowledge or
clinical practice be advanced? What will be the effect of these studies on the
concepts, methods, technologies, treatments, services, or preventative
interventions that drive this field? When relevant to the project, do scientific or technical
aspects associated with interoperability and data sharing capabilities affect
the significance of the project?
Approach: Are the
conceptual or clinical framework, design, methods, and analyses adequately
developed, well integrated, well reasoned, and appropriate to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
alternative tactics?
For applications designating multiple PDs/PIs, is the leadership approach,
including the designated roles and responsibilities, governance, and
organizational structure, consistent with and justified by the aims of the
project and the expertise of each of the PDs/PIs? When
appropriate to the proposed project, are the scientific
and technical issues associated with interoperability and data-sharing
capabilities with other relevant resources adequately addressed?
Environment: Do(es) the
scientific environment(s) in which the work will be done contribute to the
probability of success? Do the proposed studies benefit from unique features of
the scientific environment, or subject populations, or employ useful
collaborative arrangements? Is there evidence of institutional support?
In addition to the above
criteria, the following items will continue to be considered in the determination
of scientific merit and the priority score:
Inclusion of Women, Minorities and Children in Research: The adequacy of
plans to include subjects from both genders, all racial and ethnic groups (and
subgroups), and children as appropriate for the scientific goals of the
research will be assessed. Plans for the recruitment and retention of subjects
will also be evaluated. See the Human Subjects Sections of the PHS398 Research
Plan component of the SF424 (R&R)
Care and Use of Vertebrate Animals in Research: If vertebrate animals
are to be used in the project, the adequacy of the plans for their care and use
will be assessed. See the Other Research Plan Sections of the PHS398 Research
Plan component of the SF424 (R&R).
Biohazards: If materials or procedures are proposed that are potentially
hazardous to research personnel and/or the environment, determine if the
proposed protection is adequate.
Budget and Period of Support: The reasonableness of the proposed budget and the
appropriateness of the requested period of support in relation to the proposed
research may be assessed by the reviewers. The priority score should not be
affected by the evaluation of the budget.
Data Sharing Plan: The reasonableness of the
data sharing plan or the rationale for not sharing research data will be
assessed by the reviewers. However, reviewers will not factor the proposed data
sharing plan into the determination of scientific merit or the priority score.
The presence of a data sharing plan will be part of the terms and conditions of
the award. The funding organization will be responsible for monitoring the data
sharing policy.
2.D. Sharing Research
Resources
NIH
policy expects that grant recipients make unique research resources readily
available for research purposes to qualified individuals within the scientific
community after publication (See the NIH Grants Policy Statement http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part7.htm#_Toc54600131).
Investigators responding to this funding opportunity should include a sharing
research resources plan addressing how unique research resources will be shared
or explain why sharing is not possible.
Program staff will be responsible for the administrative
review of the plan for sharing research resources.
The initial review group will comment on the appropriateness
of the proposed plans for sharing research data, research resources, and
software. However, they will not factor the plans into the determination of
the scientific merit or the priority score. The adequacy of the software
sharing plans will be considered by Program staff when making recommendations
about funding applications. In making such considerations, prior to funding,
program staff may request written statements from the officials responsible for
intellectual property issues at all of the applicant institutions (including
sub-contractors), to the effect that the institution supports and agrees to
abide by the software dissemination plans put forth in the application. These
letters must be clear expressions of commitment. Program staff may negotiate
modifications of the software sharing plans with the Principal Investigator
before recommending funding of an application. The final version of the
software sharing plans negotiated by both will become a condition of the award
of the grant. The effectiveness of software sharing will be evaluated as part
of the administrative review of each Non-Competing Grant
Progress Report (PHS 2590). See Section VI.3., Reporting.
Not Applicable
Section
VI. Award Administration Information
After the peer review of the application
is completed, the PD/PI will be able to access his or her Summary Statement
(written critique) via the NIH eRA Commons.
A formal notification in the form of a Notice of Award
(NoA) will be provided to the applicant organization. The NoA signed by the
grants management officer is the authorizing document. Once all administrative
and programmatic issues have been resolved, the NoA will be generated via email
notification from the awarding component to the grantee business official.
Selection of an application for award is not an
authorization to begin performance. Any costs incurred before receipt of the
NoA are at the recipient's risk. These costs may be reimbursed only to the
extent considered allowable pre-award costs. See Section
IV.5., Funding Restrictions.
2. Administrative and National Policy Requirements
All NIH grant
and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH
Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards,
Subpart A: General and Part
II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions
for Specific Types of Grants, Grantees, and Activities.
When multiple
years are involved, awardees will be required to submit the Non-Competing Grant
Progress Report (PHS 2590) annually and financial statements as required in
the NIH
Grants Policy Statement.
1.
Scientific/Research Contact(s):
Direct general questions regarding programmatic issues to:
Center for Bioinformatics and Computational Biology
National Institute of General Medical Sciences
45
Center Drive, Room 2AS.55k, MSC 6200
Bethesda, MD 20892-6200
TEL: 301-451-6446
Email: [email protected]
Chief, Bioengineering Sciences and Technologies IRG
Center for Scientific
Review
6701 Rockledge Drive,
Room 5170
Bethesda, MD 20814
Telephone: (301) 435-1245
Fax: 301-480-1988
Email: [email protected]
Antoinette Holland
Grants Administration Branch
National Institute of General Medical Sciences
45
Center Drive, Room 2AN 50B, MSC 6200
Bethesda, MD 20892-6200
Phone: (301) 594-5132
Fax: (301) 480-2554
Email: [email protected]
Recipients of PHS support for activities involving
live, vertebrate animals must comply with PHS Policy on Humane Care and Use of
Laboratory Animals (http://grants.nih.gov/grants/olaw/references/PHSPolicyLabAnimals.pdf)
as mandated by the Health Research Extension Act of 1985 (http://grants.nih.gov/grants/olaw/references/hrea1985.htm),
and the USDA Animal Welfare Regulations (http://www.nal.usda.gov/awic/legislat/usdaleg1.htm)
as applicable.
Human Subjects Protection:
Federal regulations (45 CFR 46) require that
applications and proposals involving human subjects must be evaluated with
reference to the risks to the subjects, the adequacy of protection against
these risks, the potential benefits of the research to the subjects and others,
and the importance of the knowledge gained or to be gained (http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm).
Data and Safety Monitoring Plan:
Data and safety monitoring is required for all types
of clinical trials, including physiologic toxicity and dose-finding studies (Phase
I); efficacy studies (Phase II); efficacy, effectiveness and comparative trials
(Phase III). Monitoring should be commensurate with risk. The establishment of
data and safety monitoring boards (DSMBs) is required for multi-site clinical
trials involving interventions that entail potential risks to the participants
( NIH Policy for Data and Safety Monitoring, NIH Guide for Grants and
Contracts, http://grants.nih.gov/grants/guide/notice-files/not98-084.html).
Investigators submitting an NIH application seeking
$500,000 or more in direct costs in any single year are expected to include a
plan for data sharing or state why this is not possible (http://grants.nih.gov/grants/policy/data_sharing).
Investigators should seek guidance from their
institutions, on issues related to institutional policies and local IRB rules,
as well as local, State and Federal laws and regulations, including the Privacy
Rule. Reviewers will consider the data sharing plan but will not factor the
plan into the determination of the scientific merit or the priority score.
The Office of
Management and Budget (OMB) Circular A-110 has been revised to provide access
to research data through the Freedom of Information Act (FOIA) under some
circumstances. Data that are (1) first produced in a project that is supported
in whole or in part with Federal funds and (2) cited publicly and officially by
a Federal agency in support of an action that has the force and effect of law
(i.e., a regulation) may be accessed through FOIA. It is important for
applicants to understand the basic scope of this amendment. NIH has provided
guidance at http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm.
Applicants may wish to place data collected under this funding opportunity in a
public archive, which can provide protections for the data and manage the
distribution for an indefinite period of time. If so, the application should
include a description of the archiving plan in the study design and include
information about this in the budget justification section of the application.
In addition, applicants should think about how to structure informed consent
statements and other human subjects procedures given the potential for wider
use of data collected under this award.
Sharing of
Model Organisms:
NIH is committed
to support efforts that encourage sharing of important research resources
including the sharing of model organisms for biomedical research (see http://grants.nih.gov/grants/policy/model_organism/index.htm).
At the same time the NIH recognizes the rights of grantees and contractors to
elect and retain title to subject inventions developed with Federal funding
pursuant to the Bayh Dole Act (see the NIH
Grants Policy Statement. Beginning October 1, 2004, all investigators
submitting an NIH application or contract proposal are expected to include in
the application/proposal a description of a specific plan for sharing and
distributing unique model organism research resources generated using NIH
funding or state why such sharing is restricted or not possible. This will
permit other researchers to benefit from the resources developed with public
funding. The inclusion of a model organism sharing plan is not subject to a
cost threshold in any year and is expected to be included in all applications
where the development of model organisms is anticipated.
Inclusion of
Women And Minorities in Clinical Research:
It is the policy
of the NIH that women and members of minority groups and their sub-populations
must be included in all NIH-supported clinical research projects unless a clear
and compelling justification is provided indicating that inclusion is
inappropriate with respect to the health of the subjects or the purpose of the
research. This policy results from the NIH Revitalization Act of 1993 (Section
492B of Public Law 103-43). All investigators proposing clinical research
should read the "NIH Guidelines for Inclusion of Women and Minorities as
Subjects in Clinical Research (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html);
a complete copy of the updated Guidelines is available at http://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm.
The amended policy incorporates: the use of an NIH definition of clinical
research; updated racial and ethnic categories in compliance with the new OMB
standards; clarification of language governing NIH-defined Phase III clinical
trials consistent with the SF424 (R&R) application; and updated roles and
responsibilities of NIH staff and the extramural community. The policy
continues to require for all NIH-defined Phase III clinical trials that: a) all
applications or proposals and/or protocols must provide a description of plans
to conduct analyses, as appropriate, to address differences by sex/gender
and/or racial/ethnic groups, including subgroups if applicable; and b)
investigators must report annual accrual and progress in conducting analyses,
as appropriate, by sex/gender and/or racial/ethnic group differences.
Inclusion of
Children as Participants in Clinical Research:
The NIH maintains
a policy that children (i.e., individuals under the age of 21) must be included
in all clinical research, conducted or supported by the NIH, unless there are
scientific and ethical reasons not to include them.
All
investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines" on the inclusion of children as
participants in research involving human subjects (http://grants.nih.gov/grants/funding/children/children.htm).
Required
Education on the Protection of Human Subject Participants:
NIH policy
requires education on the protection of human subject participants for all
investigators submitting NIH applications for research involving human subjects
and individuals designated as key personnel. The policy is available at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
Human
Embryonic Stem Cells (hESC):
Criteria for
federal funding of research on hESCs can be found at http://stemcells.nih.gov/index.asp and at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html.
Only research using hESC lines that are registered in the NIH Human Embryonic
Stem Cell Registry will be eligible for Federal funding (http://escr.nih.gov/). It is the responsibility
of the applicant to provide in the project description and elsewhere in the
application as appropriate, the official NIH identifier(s) for the hESC line(s)
to be used in the proposed research. Applications that do not provide this
information will be returned without review.
NIH Public Access Policy:
NIH-funded
investigators are requested to submit to the NIH manuscript submission (NIHMS) system
(http://www.nihms.nih.gov/) at PubMed
Central (PMC) an electronic version of the author's final manuscript upon
acceptance for publication, resulting from research supported in whole or in
part with direct costs from NIH. The author's final manuscript is defined as
the final version accepted for journal publication, and includes all
modifications from the publishing peer review process.
NIH is
requesting that authors submit manuscripts resulting from 1) currently funded
NIH research projects or 2) previously supported NIH research projects if they
are accepted for publication on or after May 2, 2005. The NIH Public Access Policy applies to all research grant and career development award mechanisms,
cooperative agreements, contracts, Institutional and Individual Ruth L.
Kirschstein National Research Service Awards, as well as NIH intramural
research studies. The Policy applies to peer-reviewed, original research
publications that have been supported in whole or in part with direct costs
from NIH, but it does not apply to book chapters, editorials, reviews, or
conference proceedings. Publications resulting from non-NIH-supported research
projects should not be submitted.
For more
information about the Policy or the submission process, please visit the NIH Public Access Policy Web site at http://publicaccess.nih.gov// and view the Policy or other Resources and Tools, including the Authors' Manual.
Standards for Privacy of Individually Identifiable
Health Information:
The Department
of Health and Human Services (HHS) issued final modification to the
"Standards for Privacy of Individually Identifiable Health
Information", the "Privacy Rule", on August 14, 2002. The Privacy Rule is a federal regulation under the Health Insurance Portability and
Accountability Act (HIPAA) of 1996 that governs the protection of individually
identifiable health information, and is administered and enforced by the HHS
Office for Civil Rights (OCR).
Decisions about
applicability and implementation of the Privacy Rule reside with the researcher
and his/her institution. The OCR website (http://www.hhs.gov/ocr/)
provides information on the Privacy Rule, including a complete Regulation Text
and a set of decision tools on "Am I a covered entity?" Information
on the impact of the HIPAA Privacy Rule on NIH processes involving the review,
funding, and progress monitoring of grants, cooperative agreements, and
research contracts can be found at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.
URLs in NIH Grant Applications or Appendices:
All applications and
proposals for NIH funding must be self-contained within specified page
limitations. For publications listed in the appendix and/or Progress report,
Internet addresses (URLs) or PubMed Central (PMC) submission identification
numbers must be used for publicly accessible on-line journal
articles. Publicly accessible on-line journal articles or PMC
articles/manuscripts accepted for publication that are directly relevant to the
project may be included only as URLs or PMC submission
identification numbers accompanying the full reference in either the
Bibliography & References Cited section, the Progress Report Publication
List section, or the Biographical Sketch section of the NIH grant application.
A URL or PMC submission identification number citation may be repeated in each
of these sections as appropriate. There is no limit to the number of URLs or
PMC submission identification numbers that can be cited.
The Public
Health Service (PHS) is committed to achieving the health promotion and disease
prevention objectives of "Healthy People 2010," a PHS-led national
activity for setting priority areas. This FOA is related to one or more of the
priority areas. Potential applicants may obtain a copy of "Healthy People
2010" at http://www.health.gov/healthypeople.
Authority and
Regulations:
This program is described in the Catalog of Federal
Domestic Assistance at http://www.cfda.gov/ and is not subject to
the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review. Awards are made under
the authorization of Sections 301 and 405 of the Public Health Service Act as
amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and
45 CFR Parts 74 and 92. All awards are subject to the
terms and conditions, cost principles, and other considerations described in
the NIH
Grants Policy Statement.
The PHS strongly encourages
all grant recipients to provide a smoke-free workplace and discourage the use
of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act
of 1994, prohibits smoking in certain facilities (or in some cases, any portion
of a facility) in which regular or routine education, library, day care, health
care, or early childhood development services are provided to children. This is
consistent with the PHS mission to protect and advance the physical and mental
health of the American people.
Loan Repayment
Programs:
NIH encourages
applications for educational loan repayment from qualified health professionals
who have made a commitment to pursue a research career involving clinical,
pediatric, contraception, infertility, and health disparities related areas.
The LRP is an important component of NIH's efforts to recruit and retain the
next generation of researchers by providing the means for developing a research
career unfettered by the burden of student loan debt. Note that an NIH grant is
not required for eligibility and concurrent career award and LRP applications
are encouraged. The periods of career award and LRP award may overlap providing
the LRP recipient with the required commitment of time and effort, as LRP
awardees must commit at least 50% of their time (at least 20 hours per week
based on a 40 hour week) for two years to the research. For further
information, please see: http://www.lrp.nih.gov/.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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