Part I Overview Information

Department of Health and Human Services

Participating Organizations
National Institutes of Health (NIH), (

Components of Participating Organizations
National Center for Research Resources (NCRR), (

Title: High-End Instrumentation Grant Program

Announcement Type
This is a reissue of RFA-RR-03-009, which was previously released May 29, 2003

Update: The following update relating to this announcement has been issued:

Program Announcement (PA) Number: PAR-05-124

Catalog of Federal Domestic Assistance Number(s)

Key Dates
Release Date: June 17, 2005
Letters of Intent Receipt Date(s): August 15, 2005
Application Receipt Date(s): September 20,2005
Peer Review Date(s): February-March
Council Review Date(s): May 18, 2006
Earliest Anticipated Start Date: July 1, 2006
Expiration Date: September 21, 2005

Due Dates for E.O. 12372
Not Applicable

Additional Overview Content

Executive Summary

Table of Contents

Part I Overview Information

Part II Full Text of Announcement

 Section I. Funding Opportunity Description
   1. Research Objectives

 Section II. Award Information
   1. Mechanism(s) of Support
   2. Funds Available

 Section III. Eligibility Information
   1. Eligible Applicants
     A. Eligible Institutions
     B. Eligible Individuals
   2.Cost Sharing or Matching
   3. Other - Special Eligibility Criteria

 Section IV. Application and Submission Information
   1. Address to Request Application Information
   2. Content and Form of Application Submission
   3. Submission Dates and Times
     A. Receipt, Review and Anticipated Start Dates
       1. Letter of Intent
     B. Sending an Application to the NIH
     C. Application Processing
   4. Intergovernmental Review
   5. Funding Restrictions
   6. Other Submission Requirements

 Section V. Application Review Information
   1. Criteria
   2. Review and Selection Process
     A. Additional Review Criteria
     B. Additional Review Considerations
     C. Sharing Research Data
     D. Sharing Research Resources
   3. Anticipated Announcement and Award Dates

 Section VI. Award Administration Information
   1. Award Notices
   2. Administrative and National Policy Requirements
   3. Reporting

 Section VII. Agency Contact(s)
   1. Scientific/Research Contact(s)
   2. Peer Review Contact(s)
   3. Financial/ Grants Management Contact(s)

 Section VIII. Other Information - Required Federal Citations

Part II - Full Text of Announcement
Section I. Funding Opportunity Description

1. Research Objectives

With advances in technological development, biomedical scientists require ever more powerful tools for their research. As new instruments with enhanced performance become available, their importance for research increases along with the costs. Although the Shared Instrumentation Grant Program (SIG) provides a cost-effective mechanism for groups of NIH supported investigators to obtain commercially available equipment costing between $100,000 and $500,000, there is a continuing need for an NIH program that provides expensive, high-end instruments to the broad community of basic and clinical scientists. To meet the demands of the community, the NCRR initiated this HEI program in FY 2002 to support expensive, high-end instruments.

Examples of key instruments in this category include but are not limited to: Biomedical Imagers: The boundaries of imaging technology have been extended to acquire functional, biochemical and physiological information intact on biological systems including humans. This has led to an increased demand for multinuclear spectroscopy and functional magnetic resonance and PET imaging instruments. Nuclear Magnetic Resonance Spectrometers: There is a significant demand for increased sensitivity and resolution of high-field NMR spectrometers to determine three-dimensional structures of large proteins and protein complexes in extremely small samples. This need is magnified by the extended run time for data collection at lower fields, which limits access to these instruments. Mass Spectrometers: Instruments that combine electrospray ionization with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry are now available. The FTICR methods provide very high resolution and accurate molecular weight measurement to study large biopolymers and their interactions. Electron Microscopes: The frontier of cell biology now focuses on elucidating the nature and function of cell organelles and the role of complex protein machines. Such studies require intermediate voltage electron microscopes with field emission illumination for high resolution imaging of single molecules. Such microscopes are also needed to perform computer reconstruction at the subnanometer scale for macromolecular assemblies that are too large and complex to study by x-ray crystallography and NMR spectroscopy. Supercomputers: Computational biologists require computers or clusters of computers with high-performance visualization hardware, parallel architectures, and large data storage and transfer capabilities at increased speed. Applications for general use computer networks will not be accepted. Applications for synchrotron equipment, with the exception of detectors, will not be accepted.

For purpose of eligibility, a major user group of three or more investigators must be identified. A minimum of three major users must be Principal Investigators on NIH peer reviewed research grants at the time of the application and award. For purposes of this program, research grants are defined as those grants awarded with the following activity codes: P01, R01, U01, R35, and R37.

The application should also show a clear need for the instrumentation by projects supported by multiple NIH peer reviewed research grants (including, but not limited to those listed above) and demonstrate that these projects will require at least 75 percent of the total usage of the instrument. Major users can be individual researchers, or a group of investigators within the same department or from several departments at the applicant institution. NIH extramural awardees from other nearby institutions may also be included.

It is expected that most of the equipment requested in the HEI Program will be of a specialized nature and will require a high level of technical expertise to operate the instrument and conduct experiments. Therefore, for the requested instrument to be used effectively and to avoid abuse of instrumentation, which frequently occurs in an open access environment, the bulk of the research time may have to be reserved for a few investigators. Alternatively, some type of instruments might be accessed by the research community through collaborations with appropriate investigators. Other types of instruments requested may not be as dedicated and will serve a broadly diversified biomedical community. In any case, priority for instrument use should be given to NIH-supported scientists engaged in biomedical/behavioral research .

Each applicant institution must propose a Principal Investigator who can assume administrative/scientific oversight responsibility for the instrumentation requested. This person need not be an NIH grantee. An internal advisory committee must be named to assist the Principal Investigator in administering the grant and overseeing the responsibility for the instrument. The membership of this committee should be broadly based and include members without a conflict of interest who can resolve disputes if they arise. The Principal Investigator and the advisory committee are responsible for:

The Principal Investigator will also be responsible for:

See Section VIII, Other Information - Required Federal Citations, for policies related to this announcement.

Section II. Award Information

1. Mechanism(s) of Support

This funding opportunity will use the S10 (HEI) award mechanism. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project. HEI provides support for expensive state-of-the-art instrumentation utilized in both basic and clinical research. Applications are limited to instruments that cost at least $750,000 per instrument or integrated instrument system. Since the nature and scope of the instruments that may be requested will vary, it is anticipated that the size of an award will vary also. There is no upper limit on the cost of the instrument, but the maximum award is $2,000,000. If the amount of funds requested does not cover the total cost of the instrument, the application should describe the proposed source(s) of funding for the balance of the cost of the instrument. Documentation of the availability of the remainder of funding, signed by an appropriate institutional official, must be presented to NCRR prior to issuance of award. Awards will be made for the direct costs only. The program does not provide facilities and administrative (F&A) costs or support for construction or alterations and renovations. Matching funds are not required. However, commitment of an appropriate level of institutional support to insure the associated infrastructure is expected (building alterations, or renovations, post-award service contracts and technical personnel). Grants will be awarded for a period of one year and are not renewable. Supplemental applications will not be accepted.

This funding opportunity does not use the Just-In-Time concepts. It also uses the non-modular format (see Section IV.6. Other Submission Requirements).

Applicants proposing purchase of an instrument that the institution is planning to lease prior to award are urged to consult with their institutional sponsored projects office regarding applicable NIH policy prior to executing the leasing agreement. If the leasing agreement was executed more than one year prior to submission of the HEI application, the applicant must provide strong justification for the requested Federal funds. Further, the instrument must be considered state-of-the-art at the time of submission of the HEI application. Award adjustments may be necessary. Execution of a purchase order or agreement, making a down payment or other formal commitment to purchase the equipment prior to award must be in compliance with NIH policy regarding pre-award cost authority [see NIH Grants Policy Statement (Rev.12/03), Allow ability of Costs/Activities, Prewar (Regalement) Costs, page 94]. Non-compliance with this policy automatically eliminates an applicant from eligibility for an award.

2. Funds Available

The NCRR intends to commit approximately $21 million in FY2006 to fund approximately 11-16 new awards. The minimum award is $750,000; the maximum award is $2,000,000. Since the cost of the various instruments will vary, it is anticipated that the size of the award also will vary. The total amount awarded and the number of awards will depend on the funds available for the HEI program. Awards are for one year only. The anticipated start date is July 1, 2006.

Although the financial plans of the NCRR provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications.

Section III. Eligibility Information

1. Eligible Applicants

1.A. Eligible Institutions

You may submit an application if your institution has any of the following characteristics:

Under the general research support authority of Section 301(a)(3) of the Public Health Service Act, High-End Grant awards are made to public and non-profit domestic institutions only. These institutions include health professional schools, other academic institutions, hospitals, health departments, and research organizations. Note that Federal institutions, foreign institutions, and for-profit institutions are not eligible to apply. A Federal institution is defined by the NIH as a Cabinet-level department or independent agency of the executive branch of the Federal Government or any component organization of such a department or agency.

1.B. Eligible Individuals

Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs.

2. Cost Sharing or Matching
Cost sharing is not required.

3. Other-Special Eligibility Criteria

For purpose of eligibility, a major user group of three or more investigators must be identified. A minimum of three major users must be Principal Investigators on NIH peer reviewed research grants at the time of the application and award. For purposes of this program, research grants are defined as those grants awarded with the following activity codes: P01, R01, U01, R35, and R37.

Although the focus of the HEI Program is on a new generation of instruments that cost over $1,000,000 the floor for the program has been set at $750,000. Applications for routine instruments such as mid-field NMR spectrometers, multi-photon microscopes and other applications for requests totaling over $750,000 which are the result of an overestimation of price and/or an excessive number of accessories, will be returned as not being responsive. Identical or very similar applications may not be submitted to the SIG Program and the HEI Program. However, a revised application based on a previously reviewed SIG submission may be submitted to the HEI Program. In order to submit a revised application, the investigator must have received the summary statement from the previous review and must address the criticisms raised in the Introduction. An institution may submit more than one application, but the instruments requested should be substantially different. It is anticipated that only a few grants will be awarded in a given technological area.

Section IV. Application and Submission Information

1. Address to Request Application Information

The PHS 398 application instructions are available at in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email:

Telecommunications for the hearing impaired: TTY 301-451-5936.

2. Content and Form of Application Submission

Applications must be prepared using the most current PHS 398 research grant application instructions and forms. Applications must have a D&B Data Universal Numbering System (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling (866) 705-5711 or through the web site at The D&B number should be entered on line 11 of the face page of the PHS 398 form.

The title and number of this funding opportunity must be typed on line 2 of the face page of the application form and the YES box must be checked.

3. Submission Dates and Times
See Section IV.3.A. for details

3.A. Receipt, Review and Anticipated Start Dates

Letter of Intent Receipt Date: August 15, 2005
Application Receipt Date: September 20, 2005
Peer Review Date: February-March
Council Review Date: May 18, 2006
Earliest Anticipated Start Date: July 1, 2006

3.A.1. Letter of Intent

Prospective applicants are asked to submit a letter of intent that includes the following information:

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

The letter of intent is to be sent by the date listed at the beginning of this document. The letter of intent should be sent to:

Marjorie A. Tingle, Ph.D
Program Director
High End Instrumentation Grant Program
National Center for Research Resources
1 Democracy Building, Room 958
6701 Democracy Boulevard, MSC 4874
Bethesda, MD 20892-4874
Telephone: (301) 435-0772
Fax: (301) 480-3659

3.B. Sending an Application to the NIH

Applications must be prepared using the PHS 398 research grant application instructions and forms as described above. Submit a signed, typewritten original of the application, including the checklist, and five signed photocopies in one package to:

Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)

Personal deliveries of applications are no longer permitted (see

3.C. Application Processing

Applications must be received on or before the application receipt date described above (Section IV.3.A). If an application is received after that date, it will be returned to the applicant without review.

Upon receipt, applications will be evaluated for completeness by CSR and responsiveness by NCRR.

The NIH will not accept any application in response to this funding opportunity that is essentially the same as one currently pending initial review unless the applicant withdraws the pending application. The NIH will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of a substantial revision of an application already reviewed, but such application must include an Introduction addressing the previous critique.

Although there is no immediate acknowledgement of the receipt of an application, applicants are generally notified of the review and funding assignment within eight (8) weeks.

4. Intergovernmental Review
This initiative is not subject to intergovernmental review.

5. Funding Restrictions

All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The Grants Policy Statement can be found at

Pre-Award Costs are allowable. A grantee may, at its own risk and without NIH prior approval, incur obligations and expenditures to cover costs up to 90 days before the beginning date of the initial budget period of a new or competing continuation award if such costs: are necessary to conduct the project, and would be allowable under the grant, if awarded, without NIH prior approval. If specific expenditures would otherwise require prior approval, the grantee must obtain NIH approval before incurring the cost. NIH prior approval is required for any costs to be incurred more than 90 days before the beginning date of the initial budget period of a new or competing continuation award.

The incurrence of pre-award costs in anticipation of a competing or non-competing award imposes no obligation on NIH either to make the award or to increase the amount of the approved budget if an award is made for less than the amount anticipated and is inadequate to cover the pre-award costs incurred. NIH expects the grantee to be fully aware that pre-award costs result in borrowing against future support and that such borrowing must not impair the grantee's ability to accomplish the project objectives in the approved time frame or in any way adversely affect the conduct of the project. See NIH Grants Policy Statement

6. Other Submission Requirements

Follow the PHS 398 instructions with the following special instructions below. Do not use the format for Modular or Just-in-Time applications. Other Support pages are required (see below). This requirement supercedes the instructions for the Other Support pages in the PHS 398.

1. Form Page 1 (Face Page)

Item 1. Name the type of instrument requested.
Item 4. Not applicable
Item 5. Not applicable
Item 6. The dates should be 07/01/06 through 06/30/07.
Items 7A and 7B, 8A and 8B. Use these blocks to give the total amount requested from NCRR for this instrument or system. The direct costs and total costs for the budget period and project period must be the same.

2. Form Page 2. Complete the abstract as directed. Under “Key Personnel,” give the data on the Principal Investigator and the major user group as required.

3. Form Page 3. Complete. Insert page number(s) for user and accessory table(s) (see Research Projects)

4. Form page 4. Describe the instrument requested including manufacturer and model number. Use a continuation page(s) as necessary. The model chosen should be justified by comparing its performance with other available instruments where appropriate. Specific features and any accessories should be justified, both in this section and in the description of research projects. Provide a detailed budget breakdown of the main equipment and accessories requested including tax and import duties, if applicable. An itemized quote from a vendor should be included. If human or infectious materials, which could create a potential biohazard, are to be analyzed, funds for accessory containment equipment for the instrument may be requested in the budget. In this case, a signed letter from the institutional biosafety committee stating that they have reviewed the proposed containment plan and that the plan adheres to documented biosafety regulations is required in the application.

5. Form page 5. Budget Estimates for All Years. Not applicable; do not complete.

Modular Budget Format Page. Not applicable.

Biographical Sketch Format Page. In addition to the personnel listed on page 2, include a biographical sketch of the person(s) who will be in charge of maintenance and operation of the instrument and a brief statement of the qualifications of the individual(s).

Resources Format Page. Not applicable.

Other Support Format Page: Provide the requested information for each major user.

Research Plan

Do not include what would normally be in Items a-d of the Research Plan but provide information relative to the points identified under criteria for review including:

Justification of Need

Describe the instrument requested and the significance of the technology to biomedical research. Inventory similar instruments existing at the applicant institution, neighboring research institutions, or otherwise accessible; describe why they are unavailable or inappropriate for the proposed research. For a new generation instrument present the design concept, rational and development methods in sufficient detail to allow evaluation of its technical feasibility. Provide a clear justification why new or updated equipment, including accessories, is needed. Include specific documentation on the current usage and downtime of existing instruments and a realistic estimate of the projected usage for the requested instrument. Such documentation should be expressed as hours of use, setup time, etc., per day or week, not simply as percentage of available time. Be specific and quantitative.

Technical Expertise

Describe the technical expertise present at the institution to set up, run and maintain the instrument. Specify who will operate the instrument, train new users and ensure that it is operated safely. Are there any collaboration between disciplinary and interdisciplinary scientists for developing the technical aspects of the instrumentation? Outline the roles of the technical staff in training new users and in facilitating the adoption of these state-of-the-art techniques in the users' research programs.

Research Projects

Give a brief description of the major users projects. Since the projects have been previously peer reviewed, the project descriptions should be concise and focus on the benefit of the instrument to the research objectives of each user. Sufficient technical detail (preliminary data and/or supplemental information) should be included within the research plan to evaluate whether the instrument is appropriate, would be effectively employed, and would provide advantages over other methods. The need for special features and accessories must be justified. Individual projects that require a specific option should describe the specific studies that utilize this option. If possible, each user should highlight those publications that demonstrate the user's expertise in using the requested instrumentation. If the number of projects is large and broadly diversified, select out a smaller representative group. Use a table to list the names of the users, brief titles of the projects, the NIH grant numbers and the estimated percentage of use. Make a separate table to indicate the user's needs for the requested accessories. List the page number of each table under Table of Contents (Form Page 3). For minor users, only include a very brief (one-paragraph) summary of the research related to the need for the instruments. The combined project descriptions of the user groups should not exceed 25 pages.

Institutional Commitment

Explain how the requested instrumentation will contribute to the institution's biomedical research goals. Describe the institutional infrastructure (space, environment and utilities) available to support the instrumentation. Indicate if the institution has any history of making technology available and for keeping instruments in top operating condition.

Administration of the Instrument

Describe the organizational plan for administering the grant. Include how the instrument will be utilized, how request are made, how time will be allocated to competing research projects and how schedules are posted. Describe a plan for managing access to the instrument if users projects involve human subjects, animals or human of infectious materials. How will the results obtained be disseminated broadly to enhance scientific understanding? What are the plans for attracting new users? Include the names and titles of members of local and/or external advisory committees to oversee its use. Describe the role and responsibility of the advisory committee(s) in developing policies and procedures to assure equitable use of the instrument time and their meeting schedules.

Financial Administration

Provide a financial plan for long-term operation of the instrument. Specify how and by whom the requested instrumentation will be operated and maintained. Pertinent data on user charges, salaries of technical support personnel, maintenance contracts, instrument upgrades, shop charges and other expenses, should be included. Specify the plans for fully funding the instrument. Specify the sources and amounts of cost sharing funds (private, state or institutional funds) and a projection of when they will be available. Give a time frame or prospects for delivery of the instrument. Provide documentation (separate letters signed by appropriate institutional officials) specifically describing the institutional commitment (in dollars) in support of the instrument.

Plan for Sharing Research Data
Not applicable

Sharing Research Resources
Not applicable

Section V. Application Review Information

1. Criteria
Only the review criteria described below will be considered in the review process.

2. Review and Selection Process

Upon receipt, applications will be reviewed for completeness by the CSR and responsiveness by the NCRR. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration.

Applications that are complete and responsive to the PA will be evaluated for scientific and technical merit by specially convened initial review groups of the CSR in accordance with the review criteria stated below. As part of the initial merit review, all applications will:

The following will be considered in making funding decisions:

In making funding decisions, the NCRR will give consideration to ensure program balance among various types of instruments supported and geographic distribution of awards. The following will be considered:

Review Criteria:

Justification of Need:

Is the need for the instrument clearly and adequately justified? Is the equipment essential and appropriate? Will the instrument requested have a significant impact on biomedical/behavioral research and contribute to the advancement of human health?

Technical Expertise:

Does the institution have the high-level technical expertise and access to the necessary infrastructure to make effective use of the requested equipment? How will biosafety procedures be implemented? How well qualified are the participating investigators to operate and maintain the instrument, conduct the projects, and evaluate the research results? Are there collaborations in place between disciplinary and interdisciplinary scientists?

Research Projects:

Will research with the requested instrument advance the knowledge and understanding of the proposed projects? Will the results be disseminated broadly to enhance scientific and technological understanding? Are there appropriate plans in place for record keeping and bioinformatics?

Institutional Commitment:

What is the evidence of institutional commitment to support the instrument? Is institutional infrastructure (technical support, space, environment and utilities) available to support the instrument? Is there an institutional track record for making technology available?


Is the plan for the management and maintenance of the requested instrument appropriate? If needed, are the policies to manage human subject, animal or biohazardous materials projects adequate? Are there plans for maximizing the effectiveness of the investment in instrumentation? Is there an advisory committee for oversight of the instrument including sharing arrangements? Is the membership of the advisory committee broadly based to oversee the use of the instrument for a wide range of biomedical investigators? How will research time be allocated among the projects?

Financial Plan:

Is the financial plan for fully funding the purchase and long-term operation and maintenance of the instrument reasonable? Is there appropriate documentation (letters from institutional officials)?

2.A. Additional Review Criteria:
Not applicable

2.B. Additional Review Considerations

Budget: The reasonableness of the proposed budget and the requested period of support in relation to the proposed research. The priority score should not be affected by the evaluation of the budget.

2.C. Sharing Research Data
Not applicable

2.D. Sharing Research Resources
Not applicable

3. Anticipated Announcement and Award Dates
Not applicable

Section VI. Award Administration Information

1. Award Notices

After the peer review of the application is completed, the Principal Investigator will also receive a written critique called a Summary Statement.

A formal notification in the form of a Notice of Grant Award (NGA) will be provided to the applicant organization. The NGA signed by the grants management officer is the authorizing document. Once all administrative and programmatic issues have been resolved, the Notice of Grant Award will be generated via email notification from the awarding component to the grantee business official (designated in item 14 on the Application Face Page). If a grantee is not email enabled, a hard copy of the Notice of Grant Award will be mailed to the business official.

Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NGA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs. See Also Section IV.5. Funding Restrictions.

2. Administrative and National Policy Requirements

All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the notice of grant award. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General ( and Part II Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities (

3. Reporting

Ninety days following the end of the project period, a Final Progress report is required that describes the instrument purchased, and a list of all users and description of the value of the instrument to the investigators and to the institution as a whole. The Final Progress Report instructions are available at

Section VII. Agency Contacts

We encourage your inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants. Inquiries may fall into three areas: scientific/research, peer review, and financial or grants management issues:

1. Scientific/Research Contacts:

Marjorie A. Tingle, Ph.D.
High-End Instrumentation Grant Program
National Center for Research Resources
6701 Democracy Blvd, Bldg 1, Room 958 MSC 4874
Bethesda, MD 20892-4874 (courier service 20817)
Telephone: (301) 301-435-0772
Fax: (301) 480-3659

2. Peer Review Contacts:
Not applicable

3. Financial or Grants Management Contacts:

Ms. Jenelle D. Wiggins
Office of Grants Management
National Center for Research Resources
6701 Democracy Blvd. Bldg 1, Room 1038 MSC 4874
Bethesda, MD 20892-4874 (courier service 20817)
Telephone: (301) 435-0843
Fax: (301) 480-3777

Section VIII. Other Information

Required Federal Citations

URLs in NIH Grant Applications or Appendices:
All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Furthermore, we caution reviewers that their anonymity may be compromised when they directly access an Internet site.

Healthy People 2010:
The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This PA is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at

Authority and Regulations:
This program is described in the Catalog of Federal Domestic Assistance No.93.389, Biomedical Technology. Awards will be made under authorization of the Public Health Service Act, Title IV, Part A (Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered under NIH grants policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The NIH Grants Policy Statement can be found at

The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

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