NIDDK CAREER TRANSITION AWARD (K22) RELEASE DATE: August 21, 2002 PA NUMBER: PAR-02-151 (This PAR has been reissued, see PAR-06-002) EXPIRATION DATE: After November 18, 2004 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (http://www.niddk.nih.gov/) APPLICATION RECEIPT DATE: November 18, 2002, November 18, 2003, November 18, 2004 THIS PROGRAM ANNOUNCEMENT CONTAINS THE FOLLOWING INFORMATION o Purpose o Research Objectives o NIDDK Intramural Research Program o Mechanism of Support o Eligible Institutions o Applicant Eligibility Criteria o Special Requirements and Restrictions o Inquiries for Information o Submitting an Application o Supplemental Guidelines o Review Considerations o Selection and Award Procedures o Required Federal Citations PURPOSE The overall goals of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Career Transition Award (K22) are to enable outstanding individuals to obtain a research training experience in the NIDDK Intramural Research Program and to facilitate their successful transition to an extramural environment as independent researchers. The award will provide three years of support for research training in an NIDDK intramural laboratory followed by two years of support for an independent research program at an extramural institution. The combined duration cannot exceed five years. It is anticipated that awardees will subsequently obtain research project grants such as the R01 to support the continuation of their work. RESEARCH OBJECTIVES The NIDDK intramural research environment provides a rich and unique opportunity for the training of postdoctoral fellows and early career scientists. The goal of the NIDDK K22 program is to provide highly qualified young investigators with an opportunity to receive research training experience in the NIDDK Intramural Research Program and then to provide them with bridge funding to facilitate the transition of their research programs to extramural institutions. To achieve these objectives, the NIDDK Career Transition Award will provide a maximum total of five years of research support divided into two phases: Phase I is for research training at an intramural facility of NIDDK and Phase II is for research at a domestic, non- federal organization. NIDDK Intramural Research Program The Intramural Research Program at NIDDK conducts basic biomedical, translational, and clinical research in the broad areas of diabetes, endocrinology, metabolism, transplantation, hepatitis, digestive and kidney diseases, hematopoiesis and hemoglobinopathies. All of the major scientific disciplines are represented, including (in alphabetical order): biochemistry, bioinformatics, biophysics, biostatistics, cell biology, chemical physics, developmental biology, epidemiology, genetics, mathematical/computational biology, medicinal chemistry, molecular biology, pharmacology, physiology, and structural biology. Intramural investigators pursue a broad array of projects in biomedical research ranging from fundamental analyses of protein structure and function, through protein chemistry, cell biology, signal transduction, gene regulation, tissue development and differentiation to more applied and population-based clinical research on the genetics, etiology, pathogenesis and treatment of a variety of endocrine and renal disorders. Detailed information about potential intramural NIDDK mentors and laboratories may be obtained at http://www.niddk.nih.gov/intram/intram.htm or through a keyword search at http://intramural.nih.gov/search (choose option 3 and select NIDDK from the pull-down menu). MECHANISM OF SUPPORT This Program Announcement will use the National Institutes of Health (NIH) K22 award mechanism. Responsibility for the planning, direction, and execution of the proposed project will reside with the proposed mentor as well as with the applicant. The total period of support is a maximum of five years (three years of intramural funding and two years of extramural funding). Awards are not renewable. Total direct costs for Phase I (intramural) are based on the candidate"s experience, those for Phase II (extramural) cannot exceed $175,000 per year (for salary and research support) plus fringe benefits (specific allowable costs are described below). Transition from Phase I (the intramural period of support) to Phase II (the extramural period) is not automatic. Approval of the transition will be based on the success of the awardee"s research program as determined by yearly scientific review and by the evaluation of a research and career development plan to be carried out at the extramural institution. Additionally, the extramural institution must demonstrate a commitment to the candidate by providing protected research time, space needed to perform the proposed research, and a plan for career development. Awardees approved to proceed with the second phase of support will receive notification of approval in writing from NIDDK. An application from the extramural institution on behalf of the candidate will be required for NIDDK to process the second phase of the award (Details appear in the section "Activating the Extramural Support Phase" in this announcement). Applicants should also be aware that they are eligible to apply for up to five years of support via the Mentored Research Scientist Development Award (K01), the Mentored Clinical Scientist Development Award (K08), or the Mentored Patient-oriented Research Career Development Award (K23) in place of the two years of the K22 Phase II. Consultation with NIDDK program staff is encouraged. ELIGIBLE INSTITUTIONS Phase I o Phase I applications may only be submitted for research within the NIDDK intramural program at the National Institutes of Health (Bethesda, MD or Phoenix, AZ sites). Phase II Applications for transition to Phase II require that the extramural domestic institution falls within one or more of the following categories: o For-profit or non-profit organizations o Public or private institutions, such as universities, colleges, and hospitals o Units of state and local governments o Eligible agencies of the Federal government APPLICANT ELIGIBILITY CRITERIA Applicants must have a research or a health-professional doctorate or its equivalent, and must have some research experience, during which the potential for highly productive basic or clinical research has been demonstrated. In general, individuals who have had more than five years of postdoctoral research training at the time of application are not eligible to apply, however, clinical training does not count against the five-year rule. The required research experience may have been completed in an intramural NIH laboratory or at an extramural institution. During the intramural phase of the award, the candidate will spend full time on research. To obtain support for the extramural phase, candidates must be in a formal tenure-track (or equivalent) position in an extramural institution. During the extramural phase, the candidate must spend a minimum of 75 percent of full-time professional effort conducting research and research career development activities. Individuals from groups underrepresented in the sciences as well as individuals with disabilities are especially encouraged to apply. At the time of award, candidates must be U.S. citizens or non-citizen nationals, or must have been lawfully admitted for permanent residence and possess an Alien Registration Receipt Card (I-551) or some other verification of legal admission as a permanent resident. Non-citizen nationals are generally persons born in outlying possessions of the U.S. (i.e., American Samoa and Swains Island). Individuals on temporary or student visas are not eligible. Former principal investigators on NIH research projects (R01), FIRST Awards (R29), SBIR/STTR awards, sub-projects of program projects (P01) or center grants (P50), K08 awards, or the equivalent, are not eligible. Former principal investigators of an NIH Small Grant (R03) or Exploratory/Development Grants (R21) remain eligible. SPECIAL REQUIREMENTS Acceptance into the NIDDK Career Transition Award Program does not convey any commitment or intent of NIDDK to consider the awardee for a tenure-track position within NIDDK. The NIDDK Career Transition Award is specifically intended to help develop scientists who will pursue their careers in the extramural biomedical research community. However, NIDDK K22 awardees are not explicitly precluded from applying for available tenure- track positions at the NIH. If an awardee obtains an NIH staff or tenure-track position, the NIDDK Career Transition Award will be terminated. Once a K22 award is made, the awardee is expected to remain within the NIDDK Intramural Program for three years. The award of Phase I, the intramural segment, does not necessarily guarantee the transition to Phase II, the extramural segment. All awardees will be evaluated on a yearly basis. The second annual scientific review will also constitute the formal review to determine suitability for transition to the extramural phase of the award. Allowable costs are restricted as follows: Phase I, Intramural Support o Support during the intramural phase will include a fellowship stipend as well as research and travel expenses based on the candidate"s years of postdoctoral experience and commensurate with the NIDDK intramural salary structure. Phase II, Extramural Support Total direct costs for salary and research support may not exceed $175,000 per year plus fringe benefits. o Salary: NIDDK will provide salary for the award recipient to the same extent as that for K01, K08, and K23 awards at the time of award transition (currently $75,000 per year plus fringe benefits) for a minimum of 75 percent effort. The total salary requested must be based on a full-time, 12-month staff appointment. It must be consistent both with the established salary structure at the institution and with salaries actually provided by the institution from its own funds to other staff members of equivalent qualifications, rank, and responsibilities in the department concerned. The institution may supplement the NIH contribution up to a level that is consistent with the institution"s salary scale, however, supplementation may not be from federal funds unless specifically authorized by the federal program from which such funds are derived. Institutional supplementation of salary must not require extra duties or responsibilities that would interfere with the purpose of the K22 Award. o Research Support: NIDDK will provide up to $100,000 per year for (a) research expenses, such as supplies, equipment, and technical personnel, (b) travel to research meetings or training, and (c) statistical services, including personnel and computer time. o Ancillary Personnel Support: Salary for secretarial and administrative assistance is not allowed. o Facilities and Administrative Costs (F&A): F&A costs will be reimbursed at 8% of modified total direct costs. Activating the Extramural Support Phase The candidate must receive approval in writing from NIDDK and must be accepted by an extramural institution in a tenure-track or equivalent position in order to activate the extramural support phase. The extramural institution will submit an application on behalf of the candidate for the extramural phase of support, using Form PHS 398 (https://grants.nih.gov/grants/funding/phs398/phs398.html and https://grants.nih.gov/grants/funding/phs398/instructions2/p1_preparing _individual_CDA_app.htm). The application should include a letter from the department or division chairman describing the institution"s plan for career development. The application submitted by the awardee and the extramural institution will be evaluated by NIDDK extramural staff for completeness and responsiveness to the program. Evaluation Phase I: Intramural Support Each awardee will be evaluated for progress on an annual basis by the mentor, Laboratory or Branch Chief, and Scientific Director/Advisory Committee. The second annual scientific review will also constitute the formal review to determine suitability for transition to the extramural phase of the award. Phase II: Extramural Support The awardee will be required to submit a Form PHS 2590 non-competing continuation application for the final year of extramural support https://grants.nih.gov/grants/funding/2590/2590.htm and https://grants.nih.gov/grants/funding/2590/instructions2/ iv_cda_progress_report.htm. The application should provide a description of the research and career progress of the awardee, including: 1) publications in press or submitted, 2) current investigator-initiated research grant support, and 3) all applications submitted for investigator- initiated research grant support. It should also include a description of the extramural institution"s commitment to development of the awardee"s career. After the completion of this award, periodic updates on various aspects of employment history, publications, support from research grants or contracts, honors and awards, professional activities, and other information helpful in evaluating the impact of the program will be solicited from awardees by NIDDK"s Intramural Fellowship Office. WHERE TO SEND INQUIRIES We actively encourage inquiries concerning this Program Announcement and welcome the opportunity to answer questions from potential applicants. Inquiries generally fall into two broad areas: Direct questions about the intramural phase, including the initial application process and opportunities for scientific research within the intramural program to: Louis Simchowitz, M.D., M.B.A. Director, Office of Fellow Recruitment and Career Development National Institute of Diabetes and Digestive and Kidney Diseases Building 10, Room 9N-208 10 Center Drive Bethesda, MD 20892 301-451-9808 (voice) ls347f@nih.gov Direct questions about the extramural phase as follows: for scientific/research issues, to: Judith Podskalny, Ph.D. Program Director for Training and Career Development Digestive Diseases Center and SBIR/STTR National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Boulevard, Room 667 Bethesda, MD 20892-5450 301-594-8876 (voice) 301-480-8300 (fax) jp53s@nih.gov for peer-review issues, to: Francisco O. Calvo, Ph.D. Chief, Review Branch Division of Extramural Activities National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Boulevard, Rm. 752 Bethesda, MD 20892-5452 (for express/courier service: Bethesda, MD 20817) 301-594-8897 (voice) 301-480-3505 (fax) fc15y@nih.gov for financial/grants management issues, to: Ms. Donna Huggins Supervisory Grants Management Specialist Grants Management Branch, DEA National Institute of Diabetes and Digestive and Kidney Diseases 6707 Democracy Blvd., Room 711 Bethesda, MD 20892-5456 (For Express Mail Use Zip Code 20817) 301-594-8848 (voice) 301-480-3504 (fax) dh48v@nih.gov SUBMITTING AN APPLICATION Individuals interested in applying for the NIDDK K22 Award should contact Dr. Louis Simchowitz, Director of the Fellowship Office, as early as conveniently possible. This contact is required to initiate the process of identifying a mentor within the NIDDK Intramural Program, if one has not already been selected by the candidate, and to facilitate the application process. After forwarding a cover letter and curriculum vitae, some applicants will be invited to visit the NIH campus, at NIDDK"s expense, to meet with potential NIDDK mentors and other NIH investigators prior to submission of the full application. The rationale is to uncover and maximize synergies between candidates and NIH investigators so that together they can develop a broader approach and more comprehensive research plan for the intramural training phase at NIDDK. Information about principal investigators and laboratories in the NIDDK Intramural Research Program may be found at http://www.niddk.nih.gov/intram/intram.htm or through a keyword search at http://intramural.nih.gov/search (choose option 3 and select NIDDK from the pull-down menu). The application must include information regarding the candidate"s long-term research career plan, including descriptions of any proposed formal course work, a research training plan for the intramural phase, and the intramural mentor"s statement of support. Applications must be prepared using the PHS 398 research grant application instructions and forms (rev. 5/2001), following the instructions in Section IV, with the modifications noted below. The PHS 398 is available at https://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email: GrantsInfo@nih.gov. APPLICATION RECEIPT DATES: Applications submitted in response to this program announcement will be accepted at the standard application deadlines for Research Career Awards (K series), which are available at https://grants.nih.gov/grants/dates.htm. Please refer to the single annual set date on the face page of this announcement. SUPPLEMENTAL GUIDELINES The application must address the following issues: Candidate o Commitment to a career in biomedical research o Potential to develop into a successful independent investigator o Ability to work with other scientists in an interactive research environment o Immediate and long-term career objectives, explaining how the award will contribute to their attainment. o Career Development Plan: Applicants should describe their overall career goals and plans for continued scientific development in their research career, including the need for any courses, research techniques or methodology. Letters of Recommendation Three sealed letters of reference addressing the candidate"s potential for a research career from well-established basic or clinical scientists must be included. One letter should be from the most recent mentor in a postdoctoral research setting and one letter from the applicant"s dissertation/thesis advisor, if applicable. The letters should address the following issues: o applicant"s past contributions and scientific achievements o applicant"s special potential to pursue and develop an independent research program o applicant"s ability to work with other scientists in various interactive situations (e.g., seminars and journal clubs), on collaborative research projects, and with support staff (e.g., technicians, secretaries). Research Plan Describe the research plan as outlined in Form PHS 398 including sections on the Specific Aims, Background and Significance, Progress Report/Preliminary Studies, Research Design and Methods. The research plan should describe the use of a basic or clinical approach to a biomedical question. The scientific objectives and specific aims should describe research plans that are sufficient to justify five years of support. Applicants should also provide future research directions for the extramural support phase, i.e., what are the broad research goals and potential avenues of research that would be enhanced by the specific research project. Mentor"s Training Plan (Intramural Phase) The intramural NIDDK mentor must describe the elements of research training planned for the candidate, including any formal course-work, and specify how the candidate"s scientific independence and professional development will be promoted. SPECIFIC INSTRUCTIONS Follow the instructions in Section IV for PHS 398, with the modifications noted below. o Identify the application as a response to this Program Announcement, check "YES" on page 1, item 2 of the application and enter the Program Announcement number listed at the top of the face page of this document and "NIDDK Career Transition Award (K22)." o Enter in item 6 (Dates of Proposed Period of Support) the combined years of support needed to complete the intramural and the extramural phases of the NIDDK Career Transition Award. o Do not complete items 9-13 and 15 on the face page. o Provide applicant"s signature in item 14, a signature is not required for item 15. o Utilize "Substitute Form Page 3: Research Career Award Table of Contents." o Provide "Form Page 4: Detailed Budget for Initial Budget Period." o Provide an official certified transcript covering medical school or the graduate school level of education. o Include a biographical sketch of the candidate and the mentor. o Do not submit a Checklist Page. Budget for Intramural Phase Cost justifications should be developed in accordance with the Budget instructions in form PHS 398. Do not provide any dollar figures in the application. The candidate should work with the proposed NIDDK mentor to devise a reasonable budget for the intramural phase. The final budget will be negotiated when a selected candidate accepts a position and will be within the allowable costs specified above. Budget for Extramural Phase For candidates who receive approval for transition to the Extramural Phase, a budget will be submitted at that time as part of Form PHS 398. SENDING AN APPLICATION TO THE NIH: Submit a signed, typewritten original of the application, including the Checklist, and three signed, photocopies, in one package to: Center For Scientific Review National Institutes Of Health 6701 Rockledge Drive, Room 1040, MSC 7710 Bethesda, MD 20892-7710 Bethesda, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application must be sent to: Francisco O. Calvo, Ph.D. Chief, Review Branch Division of Extramural Activities, NIDDK 6707 Democracy Boulevard, Rm. 752 MSC 5452 Bethesda, MD 20892-5452 (for express/courier service: Bethesda, MD 20817) REVIEW CONSIDERATIONS Applications submitted for this Program Announcement will be assigned on the basis of established PHS referral guidelines. An appropriate scientific review group convened by NIDDK in accordance with the standard NIH peer review procedures (http://www.csr.nih.gov/refrev.htm) will evaluate applications for scientific and technical merit. REVIEW CRITERIA FOR THE INTRAMURAL SUPPORT PHASE Candidate o Commitment to an independent research career. o Potential to develop as an outstanding scientist who will make significant contributions to the field. o Quality and breadth of prior scientific training and experience include, where appropriate, the record of previous research support and publications. Career Development and Training Plan o Appropriateness of the proposed training experience and intramural research environment to the candidate"s career development, considering the candidate"s goals and prior experience. o Consistency of the career development plan with the candidate"s research plan and potential for contributing to the scientific literature. o Logical sequence and scientific rigor of the intramural training plan with the candidate"s research and career plans. Mentor o Research qualifications and previous experience/training record as a research supervisor. o Adequacy of the nature and extent of supervision that will occur during the proposed award period. o Appropriateness of the mentor"s research interests and qualifications to the career development needs of the candidate. o Details of the proposed mentoring plan. Research Plan o Usefulness of the research plan as a vehicle for enhancing research skills necessary to fulfill the objectives of the career development plan. o Scientific and technical merit of the research question, experimental design, and methodology, judged in the context of the candidate"s proposed career objectives. Review Criteria for the Extramural Support Phase These criteria will be applied to the evaluation that will take place at the end of the second year of intramural support. o Quality of research and career progress to date as evidenced by the record of scientific publications, receipt of honors and awards, and recognition by peers and prestigious professional societies. o Extent of the extramural institution"s provision of resources in support of the awardee"s research program and the nature of its commitment to the awardee"s career development. o Appropriateness of the budget for the scope of the research and proposed training activities. SELECTION AND AWARD PROCEDURES Funding decisions will be made based on priority score ranking, intramural program needs, and secondary review by the National Advisory Council for NIDDK. REQUIRED FEDERAL CITATIONS INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS: It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH-supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided indicating that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," published in the NIH Guide for Grants and Contracts on August 2, 2000 (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html), a complete copy of the updated Guidelines is available at https://grants.nih.gov/grants/funding/women_min/guidelines_update.htm. The revisions relate to NIH defined Phase III clinical trials and require: a) all applications or proposals and/or protocols to provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable, and b) all investigators to report accrual, and to conduct and report analyses, as appropriate, by sex/gender and/or racial/ethnic group differences. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS: It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines on the Inclusion of Children as Participants in Research Involving Human Subjects" that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not98-024.html. REQUIRED EDUCATION ON THE PROTECTION OF HUMAN SUBJECT PARTICIPANTS: NIH policy requires education on the protection of human subject participants for all investigators submitting NIH proposals for research involving human subjects. This policy announcement is found in the NIH Guide for Grants and Contracts Announcement dated June 5, 2000, at the following website: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html. PUBLIC ACCESS TO RESEARCH DATA THROUGH THE FREEDOM OF INFORMATION ACT: The Office of Management and Budget (OMB) Circular A-110 has been revised to provide public access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at: https://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. Applicants may wish to place data collected under this Program Announcement in a public archive, which can provide protections for the data and manage the distribution for an indefinite period of time. If so, the application should include a description of the archiving plan in the study design and include information about this in the budget justification section of the application. In addition, applicants should think about how to structure informed consent statements and other human subjects procedures given the potential for wider use of data collected under this award. URLS IN NIH GRANT APPLICATIONS OR APPENDICES: All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Reviewers are cautioned that their anonymity may be compromised when they directly access an Internet site. HEALTHY PEOPLE 2010: The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS led national activity for setting priority areas. This Program Announcement, "NIDDK CAREER TRANSITION AWARD (K22)," is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople. AUTHORITY AND REGULATIONS: This program is described in the Catalog of Federal Domestic Assistance No. 93.847, 93.848, and 93.849. Awards are made under authorization of sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural Research (OER) |
National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892 |
Department of Health and Human Services (HHS) |
||||||||