RELEASE DATE:  February 6, 2002

PA NUMBER:  PAR-02-056

EXPIRATION DATE:  June 30, 2005


National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)


o Purpose of the PA
o Research Objectives
o Mechanism of Support
o Eligible Institutions
o Individuals Eligible to Become Principal Investigators
o Special Requirements
o Where to Send Inquiries
o Submitting an Application
o Peer Review Process
o Review Criteria
o Award Criteria
o Required Federal Citations


The overall goals of the National Institute of Arthritis and 
Musculoskeletal and Skin Diseases (NIAMS) Career Transition Award (K22) 
program are to enable outstanding individuals to obtain a research 
training experience in the NIAMS Intramural Research Program and to 
facilitate their successful transition to an extramural environment as 
independent researchers. The award will provide two to three years of 
support for research training in an NIAMS intramural laboratory 
followed by two to three years of support for an independent research 
project in an extramural institution.  The combined duration cannot 
exceed five years.  It is anticipated that awardees will subsequently 
obtain research project grants such as the R01 to support the 
continuation of their work.


The NIAMS intramural research environment provides a rich and unique 
opportunity for the training of postdoctoral fellows and beginning 
investigators.  The goal of the NIAMS K22 program is to provide highly 
qualified young investigators with an opportunity to receive research 
training experience in the NIAMS Intramural Research Program and then 
to provide them with bridge funding to facilitate the transition of 
their research programs to extramural institutions.  To achieve these 
objectives, the NIAMS Career Transition Award will provide a maximum 
total of five years of research support divided into two phases: Phase 
I is for research in an intramural facility of NIAMS Phase II is for 
research at an extramural (non-NIH) facility.

NIAMS Intramural Research Program

The Intramural Research Program at NIAMS conducts basic, translational 
and clinical research. Intramural investigators pursue diverse projects 
in biomedical research ranging from fundamental analyses of protein 
structure and function involving crystallography, cryoelectron 
microscopy, and atomic force microscopy, through protein chemistry, 
cell biology, signal transduction, gene regulation, tissue development 
and differentiation, genetics and immunology  to more directly 
applicable research on the genetics, etiology, pathogenesis and 
treatment of a variety of rheumatic, autoimmune, inflammatory, joint, 
skin and muscle diseases. Detailed information about potential 
intramural mentors can be obtained at:  
Transition from Phase I (the intramural period of support) to Phase II 
(the extramural period) is not automatic.  Approval of the transition 
will be based on the success of the awardee's research program as 
determined by an NIAMS progress review, which will take place no later 
than the end of the second year of the Intramural Support Phase I, and 
the evaluation of a research plan to be carried out at the extramural 
institution.  Additionally, the extramural institution must demonstrate 
a commitment to the candidate by providing protected research time, 
space needed to perform the proposed research and a plan for career 
development.  Awardees approved to proceed with the second phase of 
support will receive notification of approval in writing from the 
NIAMS.  An application from the extramural institution on behalf of the 
candidate will be required for the NIAMS to process the Phase II of the 
K22 (Details appear in the section "Activating the Extramural Support 
Phase" in this announcement.) 


This PA will use the National Institutes of Health (NIH) K22 award 
mechanism.  Responsibility for the planning, direction, and execution 
of the proposed project will be solely that of the applicant.  The 
total period of support is a maximum of five years (two or three years 
intramural, and two or three years extramural).  Awards are not 
renewable.  Total direct costs for the Phase I (intramural) are based 
on the candidate's experience, not to exceed $150,000 per year, 
including salary; those for Phase II (extramural) cannot exceed 
$150,000 per year, including salary and fringe benefits. (Specific 
allowable costs are described below.)

This PA uses just-in-time concepts.  Follow the instructions for non-
modular research grant applications.


Phase I

o Phase I applications may only be submitted for research at the 
National Institutes of Health. 

Phase II

You may submit an application for transition to Phase II as described 
below if your institution has any of the following characteristics: 
o For-profit or non-profit organizations
o Public or private institutions, such as universities, colleges, 
hospitals, and laboratories
o Units of State and local governments
o Eligible agencies of the Federal government
o Domestic or foreign
o Faith-based organizations

The candidate must have a research or a health-professional doctorate 
or its equivalent, and must have some research experience, during which 
the potential for highly productive basic or clinical research was 
demonstrated.  Individuals who have had more than five years of 
postdoctoral research training at the time of application are not 
eligible to apply; however, clinical training does not count against 
the five years.  The required research experience may have been 
completed in an intramural NIH laboratory or at an extramural 
institution.  During the intramural phase of the award, the candidate 
will spend full time on research.  To obtain support for the extramural 
phase, candidates must have a formal tenure-track (or equivalent) offer 
in an extramural institution.  During the extramural phase, the 
candidate must spend a minimum of 75 percent of full-time professional 
effort conducting research and research career development activities.  
Individuals from underrepresented racial and ethnic groups as well as 
individuals with disabilities are always encouraged to apply for 
NIH programs.

Candidates must be U.S. citizens or non-citizen nationals, or must have 
been lawfully admitted for permanent residence and possess an Alien 
Registration Receipt Card (I-151 or I-551) or some other verification 
of legal admission as a permanent resident.  Individuals on temporary 
or student visas are not eligible.

Former principal investigators on NIH research projects (R01), FIRST 
Awards (R29), SBIR/STTR awards, sub-projects of program projects (P01) 
or center grants (P50), K08 awards, or the equivalent, are not 
eligible.  Former principal investigators of an NIH Small Grant (R03) 
or Exploratory/Development Grants (R21) remain eligible.  A candidate 
for the NIAMS Career Transition Award may not concurrently apply for 
any other PHS award that duplicates the provisions of this award nor 
have another application pending award. 


Acceptance into the NIAMS Career Transition Award Program does not 
convey any commitment or intent of the NIAMS to consider the awardee 
for a tenure track position within the NIAMS.  The NIAMS Career 
Transition Award is specifically intended to help develop scientists 
who will pursue their careers in the extramural biomedical research 
community.  However, the NIAMS K22 awardees are not explicitly 
precluded from applying for available tenure track positions at the 
NIH.  If an awardee obtains an NIH position, the NIAMS Career 
Transition Award will be terminated.

Once a K22 award is made, the awardee is expected to remain with the 
NIAMS Intramural Program for at least 18 months.  The award of Phase I, 
the intramural segment of a K22, does not guarantee the transition to 
the extramural segment, Phase II.

Allowable costs are restricted as follows:

o  Phase I, Intramural Support:

Support during the intramural phase will include a fellowship stipend, 
based on the candidate's years of postdoctoral experience and 
commensurate with the NIAMS intramural salary structure.  Research 
expenses including salary stipend, personnel, consultants, equipment, 
supplies, and travel will be negotiated with the Mentor and Scientific 
Director.  While the extent of these resources will depend upon salary 
and the nature and scope of the research approved by peer review, up to 
$150,000 can be requested.  Planning and managing this budget will help 
the candidate in transition to an independent research career.

o Phase II, Extramural Support:

Total direct costs, including salary, fringe benefits and research 
support, may not exceed $150,000 per year.

1. Salary:  The NIAMS will provide salary for the award recipient of up 
to $75,000 per year plus commensurate fringe benefits for a minimum of 
75 percent effort.  Although a greater effort may be proposed, the 
maximum allowable salary is $75,000.  The total salary requested must 
be based on a full-time, 12-month staff appointment.  It must be 
consistent both with the established salary structure at the 
institution and with salaries actually provided by the institution from 
its own funds to other staff members of equivalent qualifications, 
rank, and responsibilities in the department concerned.  The 
institution may supplement the NIH contribution up to a level that is 
consistent with the institution's salary scale; however, 
supplementation may not be from Federal funds unless specifically 
authorized by the Federal program from which such funds are derived. 
Institutional supplementation of salary must not require extra duties 
or responsibilities that would interfere with the purpose of the K22.

2.  Research Support:  The NIAMS will provide up to $75,000 per year 
for (a) research expenses, such as supplies, equipment, and technical 
personnel; (b) travel to research meetings or training; and (c) 
statistical services, including personnel and computer time. 

3. Ancillary Personnel Support:  Salary for secretarial and 
administrative assistance, etc., is not allowed.

4.  Facilities and Administrative Costs (F&A):  F&A costs will be 
reimbursed at eight percent of modified total direct costs.

Activating the Extramural Support Phase

The candidate must receive approval in writing from the NIAMS and must 
be accepted by an extramural institution in a tenure-track or 
equivalent position in order to activate the extramural support phase.  
The extramural institution will submit an application on behalf of the 
candidate for the extramural phase of support, using form PHS 2590, the 
noncompeting continuation application.  The application should include 
a letter from the department or division chairman describing the 
institution's plan for career development. The application submitted by 
the awardee and the extramural institution for activation of the 
extramural phase of the program will be evaluated by NIAMS extramural 
staff for completeness and responsiveness to the program.

Phase I, Intramural Support 

Each awardee will be evaluated for progress on an annual basis by the 
mentor, Laboratory Chief, and Scientific Director.

Phase II, Extramural Support 

The awardee will be required to submit a form PHS 2590 non-competing 
continuation application for the final years of extramural support.  
The application should provide a description of the research and career 
progress of the awardee, including: 1) publications in press or 
submitted; 2) current investigator-initiated research grant support; 
and 3) all applications submitted for investigator-initiated research 
grant support.  It should also include a description of the extramural 
institution's commitment to development of the awardee's career. 

After the completion of this award, periodic updates on various aspects 
of employment history, publications, support from research grants or 
contracts, honors and awards, professional activities, and other 
information helpful in evaluating the impact of the program may be 
solicited from awardees.


We encourage your inquiries concerning this PA and welcome the 
opportunity answer questions from potential applicants.  Inquiries may 
fall into three areas:  scientific/research, peer review, and financial 
or grants management issues:

Direct your questions about intramural scientific/research issues to: 
Barbara Mittleman, M.D.
Director of Scientific Interchange
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Building 10, 9 East Tower
Bethesda, MD  20892
Telephone:  (301) 402-7696

Direct your questions about extramural scientific/research issues to: 

Richard W. Lymn, Ph.D.
Muscle Biology Program
National Institute of Arthritis and Musculoskeletal and Skin Diseases
45 Center Drive, Room 5AS-49E
Bethesda, MD  20892
Telephone:  (301) 594-5128
FAX:  (301) 480-4543

Direct your questions about peer review issues to: 

Tommy Broadwater, Ph.D.
Scientific Review Branch, 
National Institute of Arthritis and Musculoskeletal and Skin Diseases
45 Center Drive, Natcher Bldg. Rm. 5A25U
Bethesda MD  20892
Telephone:  (301) 594-4953
FAX:  (301) 480-4543 

Direct your questions about financial or grants management matters to:

Melinda Nelson
Grants Management Officer
National Institute of Arthritis and Musculoskeletal and Skin Diseases
45 Center Drive, Room 5AS-49F, MSC 6500
Bethesda, MD  20892
Telephone:  (301) 594-3535
FAX:  (301) 480-5450


Individuals interested in applying for the NIAMS K22 Award should 
contact Dr. Barbara Mittleman, Director of Scientific Interchange.  
This contact is required to initiate the process of identifying a 
mentor within the NIAMS Intramural Program, if one has not already been 
selected by the candidate, and to facilitate the application process.  
Information about principal investigators in the NIAMS Intramural 
Research Program may be found on the web at  The application must 
include information regarding the candidate's long-term research career 
plan, including descriptions of any proposed formal course work, a 
research training plan for the intramural phase, and the intramural 
mentor's statement of support.

Applications must be prepared using the PHS 398 research grant 
application instructions and forms (rev. 5/2001), following the 
instructions in Section IV, with the modifications noted below.  The 
PHS 398 is available at 
in an interactive format.  For further assistance contact GrantsInfo, 
Telephone (301) 710-0267, Email:

APPLICATION RECEIPT DATES: Applications submitted in response to this 
program announcement will be accepted at the standard application 
deadlines for Research Career Awards (K series), which are available at  Application deadlines are also 
indicated in the PHS 398 application kit.


The application must address the following issues:


o The candidate's commitment to a career in biomedical or behavioral research. 

o The candidate's potential to develop into a successful 
independent investigator.

o The candidate's ability to work with other scientists in an 
interactive research environment.

o The candidate's immediate and long-term career objectives, explaining 
how the award will contribute to their attainment.

Candidate's Career Development Plan:

o Applicants should describe their overall career goals and plans for 
continued scientific development in their research career, including 
the need for any courses, research techniques or methods, etc.  The 
candidate should discuss immediate and long-term career objectives, 
explaining how the award will contribute to their attainment.

o Candidates must describe plans to receive instruction in the 
responsible conduct of research.  These plans must detail the proposed 
subject matter, format, frequency, and duration of instruction, as well 
as the amount and nature of senior staff participation.  No award will 
be made if an application lacks this component.

Letters of Recommendation

A total of three sealed letters of reference addressing the candidate's 
potential for a research career from well-established basic or clinical 
scientists must be included.  One letter should be from the most recent 
mentor in either a postdoctoral research setting or from the 
applicant's dissertation/thesis advisor.  These letters are to be 
attached to the face page of the original application.  The letters 
should address the following issues:

o The applicant's past contributions to scientific achievements

o The applicant's special potential to pursue and develop an 
independent research program

o The applicant's ability to work with other scientists in various 
interactive situations (e.g., seminars, journal clubs, etc.), on 
collaborative research projects, and with support staff (e.g., 
technicians, secretaries).

Research Plan

o Describe the research plan as outlined in form PHS 398 including 
sections on the Specific Aims, Background and Significance, Progress 
Report/Preliminary Studies, Research Design and Methods.  The research 
plan should describe the use of a basic or clinical approach to a 
biomedical or behavioral problem.  The scientific objectives and 
specific aims should describe research plans that are sufficient to 
justify five years of support.  Applicants should also provide future 
research directions for the extramural support phase, i.e., what are 
the broad research goals and potential avenues of research that would 
be stimulated by your specific research project.  

Mentor's Training Plan (Intramural Phase)

o The mentor must describe the elements of research training planned 
for the candidate, including any formal course-work, and specify how 
the candidate's scientific independence and professional development 
will be promoted. 

Specific instructions:  follow the instructions in Section IV for PHS 
398, with the modifications noted below.

o Identify the application as a response to this PA; check "YES" on 
item 2 of page 1 of the application and enter "PA-(TPA-01-123), NIAMS 
Career Transition Award (K22)."

o Enter in item 6 (Dates of Proposed Period of Support) the combined 
years of support needed to complete the intramural and the extramural 
phases of the NIAMS Career Transition Award.

o Do not complete items 9-13 and 15 on the face page.

o Provide applicant's signature in item 14; a signature is not required 
for item 15.

o Utilize "Substitute Form Page 3: Research Career Award Table of Contents."

o Provide "Form Page 4:  Detailed Budget for Initial Budget Period."

o Provide an official certified transcript covering medical school or 
the graduate school level of education.

o Include a biographical sketch of the candidate and the mentor.

o Do not submit a Checklist Page.

Budget, Phase I

o Using continuation pages as needed, provide in a narrative format 
justification for the budgetary needs of the proposed research program 
including personnel, equipment, supplies, and travel.  Cost 
justifications should be developed in accordance with the Budget 
instructions in form PHS 398.  Do not provide any dollar figures in the 
application.  The candidate should work with the potential NIAMS mentor 
to devise a reasonable budget for the intramural phase.  The final 
budget will be negotiated when a selected candidate accepts a position 
and will be within the allowable costs specified above.

Budget, Phase II

o For candidates who receive approval for transition to the Extramural 
Phase, a budget will be submitted at that time as part of the form PHS 2590.


Submit a signed, typewritten original of the application, including 
three sealed letters of recommendation, and three signed photocopies in 
one package to:

Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD  20892-7710
Bethesda, MD  20817 (for express/courier service)

At the time of submission, send an additional two signed copies of the 
application to Dr. Tommy Broadwater at the address listed under 
INQUIRIES.  Since the review will be conducted by NIAMS, it is 
important to send these two copies at the same time as the original and 
three copies are sent to the Center for Scientific Review (CSR).  These 
copies are used to help ensure the appropriate and timely review of the 
application, including identification of possible reviewers. 
APPLICATION PROCESSING: Applications must be received by or mailed 
before the receipt dates for Research Career Awards (K series) 
described at  
The CSR will not accept any application in response to this PA that is 
essentially the same as one currently pending initial review unless the 
applicant withdraws the pending application.  The CSR will not accept 
any application that is essentially the same as one already reviewed.  
This does not preclude the submission of a substantial revision of an 
application already reviewed, but such application must include an 
Introduction addressing the previous critique.


Applications submitted for this PA will be assigned on the basis of 
established PHS referral guidelines.  An appropriate scientific review 
group convened in accordance with the standard NIH peer review 
procedures ( will evaluate 
applications for scientific and technical merit.  


Upon receipt, applications will be reviewed for completeness by the 
Center for Scientific Review (CSR) and responsiveness to the PA by the 
appropriate NIAMS staff.  Applications that are complete and responsive 
to the program announcement will be evaluated for scientific and 
technical merit by an appropriate peer review group, convened by the 
NIAMS, in accordance with the review criteria stated below.

Review Criteria

Intramural Support Phase


o  Commitment to an independent research career.

o  Potential to develop as an outstanding scientist who will make 
significant contributions to the field.

o All candidates for this award must have had previous research 
experience.  Quality and breadth of prior scientific training and 
experience include, where appropriate, the record of previous research 
support and publications. 

Research Plan

o  Usefulness of the research plan as a vehicle for enhancing research 
skills necessary to fulfill the objectives of the career development plan.

o  Scientific and technical merit of the research question, design, and 
methodology, judged in the context of the candidate's proposed 
career objectives. 

o  Adequacy of plans to include both genders, minorities and their 
subgroups, and children, as appropriate for the scientific goals of the 
research.  Plans for the recruitment and retention of subjects will 
also be evaluated. 

Career Development Plan

o  Appropriateness of the proposed training experience to the 
candidate's career development, considering the candidate's goals and 
prior experience. 

o  Adequacy of plans to obtain instruction in the responsible conduct 
of research.

o  The consistency of the career development plan with the candidate's 
research plan and potential for contributing to the scientific literature.

Intramural Training Plan

o  Appropriateness of the intramural training plan, considering the 
candidate's goals and prior experience.

o  The logical sequence and scientific rigor of the intramural training 
plan with the candidates research plan.

o  Potential of the scholar to contribute to the scientific literature.


o  Research qualifications and previous experience as a research supervisor. 

o  Adequacy of the nature and extent of supervision that will occur 
during the proposed award period.

o  Appropriateness of the mentor's research interests and 
qualifications to the career development needs of the candidate.

o  Adequacy of the proposed mentoring plan.


o  Justification of budget request for the intramural phase of the 
award in relation to needs of the research project and training 
activities proposed.


Funding decisions will be made based on priority score ranking, 
intramural program needs, and secondary review by the National Advisory 
Arthritis and Musculoskeletal and Skin Diseases Council.



It is the policy of the NIH that women and members of minority groups 
and their sub-populations must be included in all NIH-supported 
biomedical and behavioral research projects involving human subjects, 
unless a clear and compelling rationale and justification are provided 
indicating that inclusion is inappropriate with respect to the health 
of the subjects or the purpose of the research.  This policy results 
from the NIH Revitalization Act of 1993 (Section 492B of Public 
Law 103-43). 

All investigators proposing research involving human subjects should 
read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities 
as Subjects in Clinical Research," published in the NIH Guide for 
Grants and Contracts on August 2, 2000 
a complete copy of the updated Guidelines is available at  
The revisions relate to NIH defined Phase III clinical trials and 
require: a) all applications or proposals and/or protocols to provide a 
description of plans to conduct analyses, as appropriate, to address 
differences by sex/gender and/or racial/ethnic groups, including 
subgroups if applicable; and b) all investigators to report accrual, 
and to conduct and report analyses, as appropriate, by sex/gender 
and/or racial/ethnic group differences.


It is the policy of NIH that children (i.e., individuals under the age 
of 21) must be included in all human subjects research, conducted or 
supported by the NIH, unless there are scientific and ethical reasons 
not to include them.  This policy applies to all initial (Type 1) 
applications submitted for receipt dates after October 1, 1998.

All investigators proposing research involving human subjects should 
read the "NIH Policy and Guidelines on the Inclusion of Children as 
Participants in Research Involving Human Subjects" that was published 
in the NIH Guide for Grants and Contracts, March 6, 1998, and is 
available at the following URL address:

Investigators also may obtain copies of these policies from the program 
staff listed under INQUIRIES.  Program staff may also provide 
additional relevant information concerning the policy.


NIH policy requires education on the protection of human subject 
participants for all investigators submitting NIH proposals for 
research involving human subjects. This policy announcement is found in 
the NIH Guide for Grants and Contracts Announcement dated June 5, 2000, 
at the following website:


The Office of Management and Budget (OMB) Circular A-110 has been 
revised to provide public access to research data through the Freedom 
of Information Act (FOIA) under some circumstances.  Data that are (1) 
first produced in a project that is supported in whole or in part with 
Federal funds and (2) cited publicly and officially by a Federal agency 
in support of an action that has the force and effect of law (i.e., a 
regulation) may be accessed through FOIA.  It is important for 
applicants to understand the basic scope of this amendment.  NIH has 
provided guidance at:

Applicants may wish to place data collected under this PA in a public 
archive, which can provide protections for the data and manage the 
distribution for an indefinite period of time.  If so, the application 
should include a description of the archiving plan in the study design 
and include information about this in the budget justification section 
of the application. In addition, applicants should think about how to 
structure informed consent statements and other human subjects 
procedures given the potential for wider use of data collected under 
this award.  


All applications and proposals for NIH funding must be self-contained 
within specified page limitations.  Unless otherwise specified in an 
NIH solicitation, internet addresses (URLs) should not be used to 
provide information necessary to the review because reviewers are under 
no obligation to view the Internet sites.  Reviewers are cautioned that 
their anonymity may be compromised when they directly access an 
Internet site. 


The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2010," a 
PHS led national activity for setting priority areas.  This Program 
Announcement, "NIAMS CAREER TRANSITION AWARD (K22)," is related to one 
or more of the priority areas.  Potential applicants may obtain a copy 
of "Healthy People 2010" at


This program is described in the Catalog of Federal Domestic Assistance 
No. 93.846.  Awards are made under authorization of sections 301 and 
405 of the Public Health Service Act as amended (42 USC 241 and 284) 
and administered under NIH grants policies and Federal Regulations 42 
CFR 52 and 45 CFR Parts 74 and 92.  This program is not subject to the 
intergovernmental review requirements of Executive Order 12372 or 
Health Systems Agency review.

The PHS strongly encourages all grant recipients to provide a smoke-
free workplace and discourage the use of all tobacco products.  In 
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits 
smoking in certain facilities (or in some cases, any portion of a 
facility) in which regular or routine education, library, day care, 
health care, or early childhood development services are provided to 
children.  This is consistent with the PHS mission to protect and 
advance the physical and mental health of the American people.

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