This Program Announcement expires on February 14, 2002 unless reissued.


Release Date:  December 20, 2001

PA NUMBER:  PAR-02-041 (see replacement PAR-04-058)

Application Deadline:  February 13

Fogarty International Center (FIC)


The International Research Scientist Development Award (IRSDA) is offered by 
the Fogarty International Center (FIC).  This program is for U.S. postdoctoral 
biomedical and behavioral scientists, in the formative stages of their 
careers, who seek an opportunity to continue research in, or extend their 
research experience into, developing countries.  It provides the successful 
candidate with a period of mentored research as part of a strong, established 
collaboration between a U.S. sponsor and a leading developing country 
scientist at an internationally recognized research institution.  It is 
expected that, following this experience, the candidate will be able to pursue 
an international research career, involving ongoing collaboration with 
developing country scientists, on research to reduce the impact of a major 
global health challenge.


The IRSDA is part of a long-term FIC strategy to support centers of research 
excellence in developing countries that address global health research 
priorities.  This support is envisioned to:

o  Attract new research talent to global health research and enhance multi-
disciplinary synergy among the research collaborators at the U.S. and foreign 

o  Leverage existing research and training support for developing country 
scientists and U.S. scientists committed to international research,

o  Support the coalescence of the critical, sustainable components necessary 
to move developing country institutions with significant potential to new 
levels of research excellence, and

o  Stimulate a more effective translation of the results of research on global 
health problems into practical public health actions.

With IRSDA support, the Investigator will have the opportunity to work 
directly with an established foreign scientist in the developing world and 
maintain a scientific base with a U.S. investigator who is involved in 
collaborative research at the developing country institution in which the 
applicant will work.  It is expected that these awards will serve to forge 
collaborative relationships between established, developing country 
researchers and outstanding U.S. junior scientists, who are potential future 
heads of basic, clinical and behavioral/social health research programs in the 
U.S..  Collaborations are expected to lead to advances that will reduce the 
impact of global health problems and narrow the gap in health disparities 
between developed and developing countries.  


The Public Health Service (PHS) is committed to achieving the health promotion 
and disease prevention objectives of "Healthy People 2010," a PHS-led national 
activity for setting priority areas.  This Program Announcement (PA), the 
International Research Scientist Development Award (IRSDA), is related to one 
or more of the priority areas.   Potential applicants may obtain a copy of 
"Healthy People 2010" at


Applications may be submitted by domestic non-profit organizations, public and 
private, such as universities, colleges, hospitals, laboratories, and units of 
state and local governments.  Racial/ethnic minority individuals, women, and 
persons with disabilities are encouraged to apply as Principal Investigators.

To be eligible for the award the applicant must:

1.  Be a U.S. citizen or non-citizen national or lawfully admitted for 
permanent residence and in possession of an Alien Registration Receipt Card 
(I-151 or I-551) or some other verification of legal admission as a permanent 
resident.  Non-citizen nationals are usually born in areas that are not states 
but are under U.S. sovereignty, jurisdiction or administration.  Individuals 
on temporary or student visas are not eligible.

2.  Hold a doctoral, dental or medical degree or the equivalent in a health 
science field.  Applicants who already have a faculty position need a letter 
of support from their institution which shows they will be granted the 
required minimum time off from clinical and teaching duties to conduct 
research at the foreign site for the required time. At least 24 months must be 
spent at the foreign site over the entire project period with four months or 
more at the foreign site each year.

3.  Have earned the relevant degree within seven years of the application 
receipt date. Any exemptions must be pre-approved by FIC staff on a case by 
case basis.

o  Time spent in clinical or other biomedical-related but non-research 
training (such as policy training), or time spent obtaining another degree 
(e.g. M.P.H.), does not count toward the seven-year limit. 
o  Candidates who are more than seven years beyond the eligible degree, but 
who have interrupted their careers because of illness or family commitments, 
may also apply.  They must clearly demonstrate the potential for productive 
independent research and the need for an additional period of mentored 
research experience in order to accomplish an effective scientific re-entry.

4.  Have demonstrated a commitment and competence in health research as well 
as the potential to engage in independent and productive biomedical, 
behavioral or epidemiological/clinical research in the period following the 

5.  Have mentors in the United States and in the eligible developing country 
where the proposed research will be performed.  

o  The U.S. mentor  must be at a U.S. institution of higher learning or non-
profit research institution.
o  The developing country mentor must be in an internationally-recognized 
developing country research institution addressing one or more of that 
country"s major health problems.  Eligible countries include those in the 
following regions:  Africa, Asia (except Japan, Singapore, South Korea and 
Taiwan), Russia and countries of the Former Soviet Union, Central and Eastern 
Europe, Latin America and the Caribbean, the Middle East (except Israel) and 
the Pacific Ocean Islands (except Australia and New Zealand).  Applications 
for work in institutions in sub-Saharan Africa are especially encouraged.  
Awards may be delayed or denied by any State Department restrictions in effect 
at the time of award.
o  The two mentors for the IRSDA applicant must be funded to collaborate with 
each other on a relevant research program or project.  Funding may include, 
but is not limited to, sources such as a National Institutes of Health (NIH) 
R01 grant with a foreign component, Fogarty International Research 
Collaboration Award, World Health Organization grant, Burroughs-Wellcome 
Foundation grant or other U.S. or international agency funding. If the 
proposed mentors had a funded collaboration for a significant period of time 
but the funding will have ended by the time of the award, please contact FIC 
staff to determine eligibility.

6.  Submit a research proposal related to but not overlapping with the 
collaborative research project of the U.S. and foreign site mentors,

7.  Be able to spend four months or more of each year in mentored research 
training at the foreign site and a total of at least 24 months over the entire 
project period.  The applicant must be able to show that the proposed period 
of support will substantially enhance his/her career and/or will allow the 
pursuit of a novel or promising approach to a particular developing country 
health research problem.

8.  Applications must be submitted on behalf of the candidate by the U.S. 
mentor"s institution, which must be a U.S.non-profit, non-Federal, public or 
private, institution of higher education (or academic medical centers 
affiliated with such institutions).  The applicant need not already be at the 
U.S. mentor"s institution at the time of application, but it is expected that 
the U.S. component of the project will be carried out by the Fellow at the 
U.S. mentor"s institution.  Any exemptions must be pre-approved by FIC staff.  


The IRSDA provides international research opportunities (in eligible 
developing countries) for U.S. postdoctoral biomedical, epidemiological, 
clinical and behavioral scientists, with cutting-edge technical training, who 
are committed to careers in international health research.  The award supports 
direct collaboration between the U.S. scientist and an established developing 
country sponsor on a research project of mutual interest in the context of an 
ongoing, funded, research relationship between the U.S. and foreign sponsors.  
The award is specifically designed to facilitate the candidate"s transition 
between the U.S. and foreign institutions and to enhance subsequent pursuit of 
an independent international research career.  In the long-term, it is 
expected that these awards will serve to forge relationships between a new 
generation of U.S. scientists and established scientists in developing 
countries.  It is expected that such ongoing collaborations will work to 
address global health problems and to reduce global health disparities.

The specific research training may be new to the candidate or an extension of 
the candidate"s prior research, but should focus on international research 
areas pertinent to global health concerns.  Applicants are encouraged to 
consult the global health research priorities defined by the World Health 
Organization ( which include, but are not limited to, 
infectious diseases, chronic/degenerative conditions, trauma/injury and mental 
health disorders, all of which can pose an increasing global burden in the 
coming decades.  Basic, behavioral/social and clinical biomedical research 
will be supported in clinical, field or laboratory settings.

The FIC recognizes that there will be significant differences in the U.S. and 
foreign institutional environments, applicants, U.S. sponsor and foreign 
mentor backgrounds and approaches to international research collaboration 
among applications.  Therefore, applicants should clearly define specific 
research and training goals, methods to achieve these goals, and specific 
measurable objectives to enable assessment of the proposed project, with 
reference to the overall goals described above.


Candidates must be able to spend four months or more of each year in mentored 
research training at the foreign site so that not less than 24 months is spent 
at the foreign site over the entire project period.  Recipients may be 
contacted periodically after the completion of the award for updates on the 
progress of their careers including their employment history, publications, 
receipt of research grants or contracts, honors and awards, professional 
activities and achievements and other information required for an evaluation 
of the impact of the program.


This PA will use the NIH career development (K01) award mechanism (general K01 
guidelines may be found at: 
The IRSDA will provide direct costs for salary for the principal 
investigator up to $75,000 (based on the actual salary scale at his/her U.S. 
institution) and applicable fringe benefits, plus an additional $20,000 for 
travel and research development support each year for up to four years.  The 
award is for an intensive, mentored research experience in a clinical, field 
or lab setting associated with a strong research collaboration at a well-
recognized research institution in a developing country.  

IRSDA grantees who obtain a tenure-track faculty position at any U.S. 
institution may submit a competitive renewal application at the same direct 
cost level described above.  At institutions or in departments where tenure-
track positions are not available, the institution must demonstrate a 
comparable commitment to the candidate at the assistant professor level or 
above.  In such cases, consultation with the IRSDA program officer is 
required.  The renewal may be for a three-year period and should be a 
continuation or extension of the research collaboration begun under the 
original K01.  Although additional training may be justified, the focus in the 
renewal should be on research.  As stipulated in the original K01 application, 
most of the proposed research should take place at the foreign site and the 
grantee is expected to spend as much time there as possible.  However, unlike 
the original competitive application, no minimum time period at the foreign 
site will be specified.  

Responsibility for the planning, direction, and execution of the proposed 
project will be that of the candidate, her/his mentor at the foreign site and 
her/his U.S. mentor on behalf of the applicant institution.  Facilities and 
administrative (F & A) costs of eight percent should be used for IRSDA 



o  Establish the candidate"s commitment to a career in international 
biomedical, clinical or behavioral research addressing a major global health 
o  Establish the candidate"s potential to develop into a successful 
independent investigator,
o  Summarize the candidate"s immediate and long-term career objectives, 
explaining how the award will contribute to their attainment.
o  Letters of recommendation.  For the original K01 application, three sealed 
letters of recommendation from senior research scientists, addressing the 
candidate"s potential for an international research career, must be included 
as part of the application.  One of the three letters should be from the 
applicant"s thesis advisor, research supervisor, chief of staff or department 
head.  Letters of recommendation should not be submitted from either the U.S. 
or foreign sponsor. 
o  For renewal applications, a letter from the applicant"s U.S. institution 
must be submitted indicating commitment to provide the candidate with the 
necessary support and time, free from clinical and teaching duties,  to 
continue the international work proposed in the application.

Career Development Plan

o  Describe the candidate"s career development plan.  The plan should 
incorporate a detailed description of Ph.D. and other previous research 
experiences as well as an explanation of long-term career goals of the 
applicant and role of this award in achieving them, including future foreign 
collaboration.  It should delineate a systematic approach to obtain the 
necessary basic biomedical or behavioral science background and research 
experience to launch an independent international research career addressing a 
major global health problem.

Training in Responsible Conduct of Research

o  Candidates must describe evidence of previous training or plans to receive 
instruction in the responsible conduct of research in an international 
context.  The topics, format, frequency and duration of instruction as well as 
the amount and nature of faculty participation should be detailed.  No award 
will be made if an application lacks this component.

Research Plan

o  Describe the research plan as outlined in form PHS 398 and the use of a 
basic science or clinical approach to a biomedical or behavioral problem 
including the Specific Aims, Background and Significance, Progress 
Report/Preliminary Studies, Research Design and Methods sections.  It should 
include an annual schedule of planned research activities at the U.S. and 
foreign sites during that period.  The research plan should serve as a 
justification for conducting research abroad and provide a clear description 
of the relationship between the proposed research and current research efforts 
at U.S. and foreign labs.

o  For renewal applications, describe progress made under the original K01 and 
how the research proposed in the renewal continues or extends the original 

U.S. and Foreign Mentor Statements

o  The applications must include information from the U.S. and foreign mentors 
including their funded research collaboration and their research 
qualifications and previous experience and record in supervising research 
training (number of Ph.D. and post-docs mentored and their current career 
status).  Both the U.S. and foreign mentors should submit Biographical 
Sketches, Other Support and Resources Forms.  The application must also 
include a detailed plan for the supervision of the Fellow, by both mentors, at 
each institution, during the proposed award period.

U.S. and Foreign Institutional Commitments

o  The extent and quality of the research environment, relevant to the 
candidate"s research focus, should be described for the U.S. and foreign 
institutions.  The research environment includes faculty and staff capable of 
productive collaboration with the candidate, seminars and opportunities for 
interactions with other research groups and scientists and available research 
facilities and equipment.

o  A detailed description of overall research funding at the foreign 
institution (government, non-government and international sources), specific 
for the proposed research area, should be included to support its status as an 
existing or potential center of research excellence.


o  Budget requests must be provided according to instructions in form PHS 398 
(rev. 5/2001)

Allowable Costs:

1.  Salary and fringe benefits for up to $75,000 per year (based on the actual 
salary scale at the U.S. institution).  The institution may supplement the NIH 
contribution to the candidate"s salary up to a level that is consistent with 
the institution"s salary scale.  Institutional supplementation of salary must 
not require extra duties or responsibilities that would interfere with the 
purpose of the award. 

2.  Research Development Support: These funds may be used for expenses such 
as:  (a) tuition, fees, and books related to career development, (b) research  
expenses, such as supplies, equipment and technical personnel, (c) language 
training, (d) statistical and computational services (including personnel and 
computer time, (e) in-country travel required for research, research meetings 
or training, round trip economy class airfare (on a U.S. carrier) and 
necessary ground transportation for the candidate to and from the foreign site 
over the duration of the project, roundtrip economy airfare for each dependent 
accompanying the awardee for four months or more abroad, 

3.  Ancillary Personnel Support:  Salary for mentors, secretarial and 
administrative assistance, etc., is not allowed.

All expenses must be directly related to the proposed research career 
development program.  Facilities and Administrative costs of eight percent are 
applied to allowable 
direct costs.

Concurrent Applications

IRSDA applications may not be submitted or awarded concurrently with other NIH 
applications, such as the Independent Scientist Award, Mentored Clinical 
Scientist Development Award, Academic Award, Research Project Grant, or 
Mentored Patient-Oriented Research Career Development Award.

Subsequent Applications for NIH Research Support

Subsequent to receiving the K01 Award, incumbents are encouraged to apply for 
independent research support (e.g., R01, etc.).  K01 recipients who are 
successful in obtaining NIH research grant support may not receive salary 
support from the research grant for the duration of the award except under 
certain circumstances and with prior FIC approval.  After the conclusion or 
termination of the award, salary support should transfer to the research 
grant.  K01 recipients who apply for research grant support are encouraged to 
include salary and all other research needs in the research grant application 
for the period following completion of the K01.  Alternatively, recipients of 
research grant awards may terminate the K01 prior to the start of the research 


It is the policy of the NIH that women and members of minority groups and 
their sub-populations must be included in all NIH-supported clinical research 
projects unless a clear and compelling justification is provided indicating 
that inclusion is inappropriate with respect to the health of the subjects or 
the purpose of the research. This policy results from the NIH Revitalization 
Act of 1993 (Section 492B of Public Law 103-43).

All investigators proposing clinical research should read the AMENDMENT "NIH 
Guidelines for Inclusion of Women and Minorities as Subjects in Clinical 
Research - Amended, October, 2001," published in the NIH Guide for Grants and 
Contracts on October 9, 2001 
a complete copy of the updated Guidelines are available at  
The amended policy incorporates: the use of an NIH definition of 
clinical research, updated racial and ethnic categories in compliance with 
the new OMB standards, clarification of language governing NIH-defined Phase 
III clinical trials consistent with the new PHS Form 398, and updated roles 
and responsibilities of NIH staff and the extramural community.  The policy 
continues to require for all NIH-defined Phase III clinical trials that: a) 
all applications or proposals and/or protocols must provide a description of 
plans to conduct analyses, as appropriate, to address differences by 
sex/gender and/or racial/ethnic groups, including subgroups if applicable, 
and b) investigators must report annual accrual and progress in conducting 
analyses, as appropriate, by sex/gender and/or racial/ethnic group 


It is the policy of NIH that children (i.e., individuals under the age of 21) 
must be included in all human subjects research, conducted or supported by the 
NIH, unless there are scientific and ethical reasons not to include them.  
This policy applies to all initial (Type 1) applications submitted for receipt 
dates after October 1, 1998.

All investigators proposing research involving human subjects should read the 
"NIH Policy and Guidelines on the Inclusion of Children as Participants in 
Research Involving Human Subjects" that was published in the NIH Guide for 
Grants and Contracts, March 6, 1998, and is available at the following URL 

Investigators also may obtain copies of these policies from the program staff 
listed under INQUIRIES.  Program staff may also provide additional relevant 
information concerning the policy.


All applications and proposals for NIH funding must be self-contained within 
specified page limitations.  Unless otherwise specified in an NIH 
solicitation, internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no obligation 
to view the Internet sites.  Reviewers are cautioned that their anonymity may 
be compromised when they directly access an Internet site.


NIH policy required education on the protection of human subject participants 
for all investigators submitting NIH proposals for research involving human 
subjects.  This policy announcement is found in the NIH Guide for Grants and 
Contracts Announcement dated June 5, 2000, at the following website:


The Office of Management and Budget (OMB) Circular A-110 has been revised to 
provide public access to research data through the Freedom of Information Act 
(FOIA) under some circumstances.  Data that are (1) first produced in a 
project that is supported in whole or in part with Federal funds and (2) cited 
publicly and officially by a Federal agency in support of an action that has 
the force and effect of law (i.e., a regulation) may be accessed through FOIA.  
It is important for applicants to understand the basic scope of this 
amendment.  NIH has provided guidance at:

Applicants may wish to place data collected under this PA in a public archive, 
which can provide protections for the data and manage the distribution for an 
indefinite period of time.  If so, the application should include a 
description of the archiving plan in the study design and include information 
about this in the budget justification section of the application. In 
addition, applicants should think about how to structure informed consent 
statements and other human subjects procedures given the potential for wider 
use of data collected under this award.


The PHS 398 research grant application instructions and forms (rev. 5/2001) at must be used in 
applying for these grants (  This 
version of the PHS 398 is available in an interactive, searchable format.  
Beginning January 10, 2002, the NIH will return applications that are not 
submitted on the 5/2001 version.  For further assistance contact GrantsInfo, 
Telephone 301/710-0267, Email:  Applicants should use the 
additional instructions for preparing an Individual Research Career 
Development Award Application "K" series on pages IV1-IV7 in Form 398 when 
preparing their applications.

The title and number of the program announcement must be typed on line two of 
the face page and the YES box must be marked. 

Submit a signed, typewritten original of the application, including the 
Checklist, three sealed letters of recommendation, and three signed 
photocopies in one package to:

BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)

Send two copies and appendices to Dr. Madelon Halula (listed in INQUIRIES 

Applications must be received by the application receipt date listed in the 
heading of this PA.  If an application is received after that date, it will be 
returned to the applicant without review. 

The Center for Scientific Review (CSR) will not accept any application in 
response to this PA that is essentially the same as one currently pending 
initial review, unless the applicant withdraws the pending application.  This 
does not preclude submission of substantial revisions of an application 
already reviewed, but such applications must include an Introduction 
addressing the previous critique.


Applications will be reviewed for completeness by CSR.  Incomplete 
applications will be returned to the applicant without further consideration.

Applications that are complete and responsive to the PA will be evaluated for 
scientific and technical merit.  Peer review will be conducted by an 
appropriate scientific review group convened by the National Institute of 
Allergy and Infectious Diseases (NIAID) in accordance with the standard NIH 
peer review procedures.  As part of the initial merit review, all applications 
will receive a written critique and may undergo a process in which only those 
applications deemed to have the highest scientific merit, generally the top 
half of applications under review, will be discussed, assigned a priority 
score, and receive a second level review by the FIC Advisory Board.

Review Criteria

The goals of NIH-supported research are to advance our understanding of 
biological systems, improve the control of disease, and enhance health.  

The following specific review criteria will be applied:


o  Commitment to an independent international research career including 
potential to contribute to knowledge that will address a major global health 
o  Potential to develop (or evidence of the capacity to develop) as an 
independent investigator pursuing international research,
o  Quality and relevance of prior scientific training and experience including 
detailed description of previous research, record of previous research support 
and publications.

Career Development Plan

o  Likelihood that the research and training in the plan will contribute 
substantially to the scientific development of the candidate, the achievement 
of scientific independence and ongoing involvement in collaborative 
international research,
o  Appropriateness of the plan to the career goals of the candidate,
o  Appropriateness of the plan to increase conceptual and theoretical 
knowledge in the research area proposed,
o  Consistency of the plan with the candidate"s prior training, research and 
academic experience and the stated career goals,
o  Clarity of the goals and scope of the plan and the need for the proposed 
research and training experience at the foreign site,
o  Adequacy of the proposed training for responsible conduct of research in an 
international context,
o  Clear description of the roles of the U.S. and foreign mentors in the 
training and research planned.

Research Plan

o  Usefulness of the research plan as a vehicle for enhancing existing 
research skills as described in the career development plan,
o  Scientific and technical merit of the research question, design and 
methodology judged in the context of the candidate"s previous training and 
o  Relevance of the proposed research to a major global health problem,
o  Relevance of the proposed research to the candidate"s career objectives.

U.S. and Foreign Mentors

o  Appropriateness of U.S. and foreign mentors" ongoing funded collaborative 
research and their other research and training qualifications for the proposed 
o  The extent of the commitment of each mentor to supervising and guiding the 
candidate throughout the award period,
o  Adequacy of each mentor"s previous experience in fostering the development 
of independent researchers highlighting persons involved in international 
o  Adequacy of each mentor"s research productivity and grant support related 
to the proposed project.

U.S. and Foreign Institutional Environment

o  Adequacy of the research facilities at the U.S. and foreign institutions,
o  Adequacy of the training opportunities and quality of the environment for 
scientific and professional development at the U.S. and foreign institutions.


o  Justify the budget requests in relation to career development goals and 
research aims and plans.


Award criteria that will be used to make award decisions include:

o  scientific, technical and educational merit (as determined by peer review)
o  availability of funds
o  the likelihood that the proposal will contribute to the achievement of 
FIC"s objectives.


Inquiries concerning this PA are encouraged.  The opportunity to clarify any 
issues or questions from potential applicants is welcome.

Direct inquiries regarding programmatic issues to:

Dr. Kathleen Michels
Division of International Training and Research
Fogarty International Center
Building 31, Room B2C39
31 Center Drive, MSC 2220
Bethesda, MD  20892-2220
Telephone:  301-496-1653
Fax:  301-402-0779

Or to:

Julie Marquardt
Division of International Training and Research
Fogarty International Center
Building 31, Room B2C39
Bethesda, MD  20892-2220
Telephone:  301-496-1653
Fax:  301-402-0779

Direct inquiries regarding review issues to:  

Madelon Halula, Ph.D.
Scientific Review Program
6700-B Rockledge Blvd., Room 2217, MSC 7616
Bethesda, MD  20892-7616
Bethesda, MD  20817 (express/courier service)
Telephone:  301-402-2636
Fax:  301-402-2638

Direct inquiries regarding fiscal matters to:

Bruce Butrum
Grants Management Office
Fogarty International Center
Building 31, Room B2C29
31 Center Drive, MSC 2220
Bethesda, MD  20892-2220
Telephone:  301-451-6830
Fax:  301-594-1211


This program is described in the Catalog of Federal Domestic Assistance No. 
93.989.  Awards are made under authorization of sections 301 and 405 of the 
Public Health Service Act as amended (42 USC 241 and 284) and administered 
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 
74 and 92.  This program is not subject to the intergovernmental review 
requirements of Executive Order 12372 or Health Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a 
smoke-free workplace and promote the non-use of all tobacco products.  In 
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking 
in certain facilities (or in some cases, and portion of a facility) in which 
regular or routine education, library, day care, health care or early 
childhood development services are provided to children.  This is consistent 
with the PHS mission to protect and advance the physical and mental health of 
the American people.

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
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