Release Date:  December 13, 2001
PA NUMBER:  PAR-02-036
National Center for Research Resources
Application Receipt Date:  March 22, 2002
The National Center for Research Resources (NCRR) is continuing its 
competitive Shared Instrumentation Grant (SIG) Program initiated in 
Fiscal Year 1982.  Results of the most recent study, "The National 
Survey of Academic Research Instruments and Instrumentation," published 
in 1997 identified bioanalytical equipment of the type provided through 
this Program as the top most priority.  The objective of the program is 
to make available to institutions expensive research instruments that 
can only be justified on a shared-use basis and for which meritorious 
research projects are described.  The SIG Program provides a cost-
effective mechanism for groups of NIH-supported investigators to obtain 
commercially available, technologically sophisticated equipment costing 
more than $100,000.
Under the general research support authority of Section 301(a)(3) of 
the Public Health Service Act, Shared Instrumentation Grant awards are 
made to public and non-profit domestic institutions only. These 
institutions include health professional schools, other academic 
institutions, hospitals, health departments, and research 
organizations. Note that, Federal institutions, foreign institutions, 
and for-profit institutions are not eligible to apply. A Federal 
institution is defined by the NIH as a Cabinet-level department or 
independent agency of the executive branch of the Federal Government or 
any component organization of such a department or agency. 
Racial/ethnic minority individuals, women, and persons with 
disabilities are encouraged to apply as Principal Investigators.
To be eligible, the application must identify three or more NIH funded 
investigators (Principal Investigators of active P01, R01, U01, R29, 
R35 or R37 research grants) who will be users of the requested 
instrument. The Principal Investigator of the SIG application does not 
need to have an active NIH research grant or be a user of the requested 
Applications will be accepted that request a single, commercially 
available instrument or integrated instrument system which costs at 
least $100,000. There is no restriction on the number of applications 
an institution can submit to the SIG program each year provided the 
applications request different types of equipment. However, if two or 
more applications are submitted for similar equipment (for example, two 
600 MHz NMR spectrometers) from the same institution, documentation 
from a high level institutional official must be provided stating that 
this is not an unintended duplication, but part of a campus wide 
institutional plan. An application requesting more than one type of 
instrumentation (for example, a mass spectrometer and a confocal 
microscope) will not be considered responsive to this program 
announcement and will be returned.
Awards under this Program Announcement (PA) will use the SIG mechanism 
(S10). SIG provides support for expensive state-of-the-art 
instrumentation utilized in both basic and clinical research.  
Applications are limited to instruments that cost at least $100,000 per 
instrument or integrated instrument system.  The maximum award is 
$500,000.  Since the nature and scope of the instruments that may be 
requested will vary, it is anticipated that the size of an award will 
vary also.  Awards will be made for the direct costs only.  The 
institution must meet those costs (not covered in the normal purchase 
price) required to place the instrumentation in operational order as 
well as the maintenance, support personnel, and service costs 
associated with maximum utilization of the instrument.  There is no 
upper limit on the cost of the instrument, but the maximum award is 
$500,000.  Grants will be awarded for a period of one year and are not 
renewable.  Supplemental applications will not be accepted.  The 
program does not provide facilities and administrative (F&A) costs or 
support for construction or alterations and renovations.  Cost sharing 
is not required.  If the amount of funds requested does not cover the 
total cost of the instrument, the application should describe the 
proposed source(s) of funding for the balance of the cost of the 
instrument.  Documentation of the availability of the remainder of 
funding, signed by an appropriate institutional official, must be 
presented to NCRR prior to issuance of award.
Applicants proposing purchase of an instrument that the institution is 
planning to lease prior to award are urged to consult with their 
institutional sponsored projects office regarding applicable NIH policy 
prior to executing the leasing agreement.  If the leasing agreement was 
executed more than one year prior to submission of the SIG application, 
the applicant must provide strong justification for the requested 
Federal funds. Further, the instrument must be considered state-of-the-
art at the time of submission of the SIG application. Award adjustments 
may be necessary.  Execution of a purchase agreement, processing of a 
purchase order, making a down payment or other formal obligation or 
commitment to purchase the proposed equipment by the applicant 
institution prior to award is subject to NIH policy regarding pre-award 
cost authority.
This program is designed to provide for the acquisition or updating of 
expensive shared-use instrumentation not generally available through 
other NIH mechanisms, such as the regular research project, program 
project, or center grant programs. Proposals for research on advancing 
the design or for the development of new instrumentation will not be 
Types of instrumentation supported include, but are not limited to, 
nuclear magnetic resonance systems, electron and confocal microscopes, 
mass spectrometers, protein and DNA sequencers, biosensors, x-ray 
diffractometers and cell sorters. Support will not be provided for 
general purpose equipment or purely instructional equipment, personal 
computers, personal workstations, printers, and Ethernet interfaces. 
Proposals for "stand alone" computer systems will only be considered if 
the instrument is solely dedicated to the research needs of a broad 
community of NIH-supported investigators.

For purposes of eligibility, a major user group of three or more 
investigators must be identified.  A minimum of three major users must 
be Principal Investigators on NIH peer reviewed research grants at the 
time of the application and award. For purposes of this program, 
research grants are defined as those grants awarded with the following 
activity codes: P01, R01, U01, R29, R35 and R37. 

In addition to the above eligibility criteria, the application should 
also show a clear need for the instrumentation by projects supported by 
multiple NIH peer review research grants (including, but not limited to 
those listed above) and demonstrate that these projects will require at 
least 75 percent of the total usage of the instrument. Major users can 
be individual researchers, or a group of investigators within the same 
department or from several departments at the applicant institution. 
NIH extramural awardees from other nearby institutions may also be 
If the major user group does not require total usage of the instrument, 
access to the instrument should be made available to other users upon 
the advice of the internal advisory committee (see below). These users 
need not be NIH awardees, but priority should be given to NIH-supported 
scientists engaged in biomedical/behavioral research. To promote cost 
effectiveness, to encourage optimal sharing among individual 
investigators, research groups and departments, and to foster a 
collaborative multidisciplinary environment, the instrument should be 
integrated into a central core facility, whenever possible.
Each applicant institution must propose a Principal Investigator who 
can assume administrative/scientific oversight responsibility for the 
instrumentation requested. This person need not be an NIH grantee. An 
internal advisory committee to assist in this responsibility should 
also be utilized. The Principal Investigator and the advisory group are 
responsible for the development of guidelines for shared use of the 
instrument, for preparation of all reports required by the NIH, for 
relocation of the instrument within the grantee institution if the 
major user group is significantly altered, and for continued financial 
support for the maximum utilization and maintenance of the instrument 
in the post-award period.
The application must include a plan for the day-to-day management of 
the instrument including designation of a qualified individual to 
supervise the operation of the instrument and to provide technical 
expertise to the users. Specific plans for sharing arrangements and for 
monitoring the use of the instrument should be described. If a grant 
award is made, a final progress report is required that describes the 
use of the instrument, listing all users and indicating the value of 
the instrumentation to the research of the major users and to the 
institution as a whole. This report must be submitted to NCRR 90 days 
following the end of the project period.
All applications and proposals for NIH funding must be self-contained 
within specified page limitations. Unless otherwise specified in an NIH 
solicitation, Internet addresses (URLs) should not be used to provide 
information necessary to the review because reviewers are under no 
obligation to view the Internet sites. Reviewers are cautioned that 
their anonymity may be compromised when they directly access an 
Internet site.
The PHS 398 research grant application instructions and forms (rev. 
5/01) at must be used 
in applying for these grants. This version of the PHS 398 is available 
in an interactive, searchable format. For further assistance contact 
Grants Info, Telephone 301/710-0267, Email:
Follow the PHS 398 instructions with the following special instructions 
Do not use the format for Modular Grant applications.

1.     Form Page 1 (Face Page)
Item 1. Name the type of instrument requested.
Item 2. Check the box marked "YES" and enter the number and title of 
this program announcement.
Item 4. Not applicable
Item 5. Not applicable
Item 6. The dates should be 04/01/03 through 03/31/04.
Items 7A and 7B, 8A and 8B. Use these blocks to give the total amount 
requested from NCRR for this instrument or system. The direct costs and 
total costs for the budget period and project period must be the same. 

2.    Form Page 2. Complete the abstract as directed. Under "Key 
Personnel," give the data on the Principal Investigator and the major 
user group as required. 

3.    Form Page 3. Complete. Insert page number(s) for user and accessory 
table(s) (see Research Projects) 
4. Form page 4. Describe the instrument requested including 
manufacturer and model number. Use a continuation page(s) as necessary. 
The model chosen should be justified by comparing its performance with 
other available instruments where appropriate. Specific features and 
any accessories should be justified, both in this section and in the 
description of research projects. Provide a detailed budget breakdown 
of the main equipment and accessories requested including tax and 
import duties, if applicable. An itemized quote from a vendor should be 
included. If a project involves a potential biohazard, funds for 
accessory containment equipment for the instrument or instrument system 
may be included in the 
requested budget.
5. Form page 5. Budget Estimates for All Years.  Not applicable; do not 
Modular Budget Format Page. Not applicable
Biographical Sketch Format Page.  In addition to the personnel listed 
on page 2, include a biographical sketch of the person(s) who will be 
in charge of maintenance and operation of the instrument and a brief 
statement of the qualifications of the individual(s). Biographical 
sketches should not exceed 4 pages for each individual.
Resources Format Page. Not applicable
Checklist Form Page. Check all that apply.
Personal Data Form Page. Complete
Other Support Format Page.  Provide the requested information for each 
major user and for each application for the same instrumentation sent 
to NSF or another organization or agency.
Personnel Report Format Page. Not applicable
Targeted/Planned Enrollment Format Page. Not applicable
Enrollment Format Page. Not applicable
Research Plan section of the application. (If this is a revised 
application, note the special instructions on page 15 in the PHS 398 
instructions regarding completion of this section of the application). 
Do not include what would normally be in Items a-d of the Research Plan 
but provide information relative to the points identified under 
criteria for review including:
Instrument Requested

Describe the instrument requested. Inventory similar instruments 
existing at the applicant institution, neighboring research 
institutions, or otherwise accessible; describe why they are 
unavailable or inappropriate for the proposed research. Provide a clear 
justification why new or updated equipment, including accessories, is 
needed. Include specific documentation on the current usage and 
downtime of existing instruments and a realistic estimate of the 
projected usage for the requested instrument.

 Research Projects

Give a brief description of the major users projects. Since the 
projects have been previously peer reviewed, the project descriptions 
should be concise and focus on the benefit of the instrument to the 
research objectives of each user. Sufficient technical detail 
(preliminary data and/or supplemental information) should be included 
to evaluate whether the instrument is appropriate, would be effectively 
employed, and would provide advantages over other methods. The need for 
special features and accessories must be justified. If possible, each 
user should highlight those publications that demonstrate the user's 
expertise in using the requested instrumentation. If the number of 
projects is large and broadly diversified, select out a smaller 
representative group. Use a table to list the names of the users, brief 
titles of the projects, the NIH grant numbers and the estimated 
percentage of use. Make a separate table to indicate the user's needs 
for the requested accessories. List the page number of each table under 
Table of Contents (Form Page 3). For minor users, only include a very 
brief (one-paragraph) summary of the research related to the need for 
the instruments. The combined project descriptions of the user groups 
should not exceed 25 pages.

Technical Expertise 
Describe the technical expertise present at the institution to set up, 
run and maintain the instrument. Specify who will operate the 
instrument and train new users.

Organizational / Management Plan
Describe the organizational plan to administer the grant. Include how 
the instrument will be utilized, how requests are made, how time will 
be allocated among major and minor users and plans for attracting new 
users. List the names and titles of the members of the local advisory 
committee to oversee instrument use. Indicate the role and 
responsibility of the advisory committee in developing and implementing 
policies and procedures to assure equitable use of the instrument.
Submit a specific financial plan for long-term operation and 
maintenance of the instrument. Explain how the costs to place the 
instrument in operational order as well as the maintenance, support 
personnel, and service costs associated with effective use of the 
instrument will be met. 
Institutional Commitment
Describe the institutional infrastructure available to support the 
instrumentation. Provide documentation (e.g., separate letters signed 
by appropriate institutional officials) specifically describing the 
required institutional commitment (in dollars) in support of the 
proposed plan.
Overall Benefit
Explain how the instrument will impact NIH funded research and 
contribute to the institution's long- range biomedical research goals. 
Applications must be received by March 22, 2002. Applications received 
after this date will not be accepted for review in this competition and 
will be returned to the applicant. The completed, signed original and 
four exact photocopies of the signed application and any appendix 
material must be sent to:
ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service)
Do not send applications for different instruments in the same package.
One copy of the application must be sent to:
6705 ROCKLEDGE DRIVE, ROOM 6148 - MSC 7965
BETHESDA, MD  20892-7965
BETHESDA, MD  20817 (for express/courier service)

Applications will be reviewed for completeness by CSR and 
responsiveness by NCRR.  Applications that are complete and responsive 
to the program announcement will be evaluated for scientific and 
technical merit by specially convened initial review groups of the 
Center for Scientific Review (CSR) with a second level review by the 
National Advisory Research Resources Council (NARRC). Approximately 
half of the applications will be reviewed at the September 2002 NARRC 
meeting and the remainder at the NARRC meeting in January 2003. Funding 
decisions on all applications received for the March 22, 2002, deadline 
will not be made until the program receives an appropriation for FY 
2003. The Council date will not affect the likelihood of funding. 

A recent NIH/NSF Memorandum of Understanding permits the joint agency 
review and funding of requests for a single instrument costing more 
than $500,000, which would normally be eligible for submission to both 
NIH and NSF.  Such a request may be submitted to NIH for the March 22 
deadline for review by NIH with NSF participation, thus avoiding 
separate agency peer review.  Under this arrangement, the agencies may 
offer joint funding in excess of their current award limits.  
Applicants contemplating joint NIH-NSF submission are strongly urged to 
contact both the NSF Division of Biological Infrastructure (NSF 
contact:  Multi-User Biological Instrumentation Program Officer:; (703-292-8470) and the NCRR SIG Program (Dr. Marjorie 
A. Tingle 301-435-0772; for information concerning 
eligibility and required documentation.
The Scientific Need

The extent to which an award for the specific instrument would meet the 
scientific needs and enhance the planned research endeavors of the 
major users by providing an instrument that is unavailable or to which 
availability is highly limited.
Technical Expertise

The availability and commitment of the appropriate technical expertise 
within the major user group or the institution for use of the 
Management Plan

The adequacy of the organizational plan for use of the instrument and 
the internal advisory committee for oversight of the instrument 
including sharing arrangements.
Institutional Commitment

The institution's commitment for continued support of the utilization 
and maintenance of the instrument.
Overall Benefit

The benefit of the proposed instrument to the overall research 
community it will serve.
In making funding decisions, the NCRR will give consideration to ensure 
program balance among various types of instruments supported and 
geographic distribution of awards.
Inquiries are encouraged. The opportunities to clarify any issues or 
questions from potential applicants are welcome.
Direct inquiries regarding programmatic or scientific issues to:
Marjorie A. Tingle, Ph.D.
Shared Instrumentation Grant Program
National Center for Research Resources
6705 Rockledge Drive, Room 6148, MSC 7965
Bethesda, MD  20892-7965
Telephone:  (301) 435-0772
FAX:  (301) 480-3659
Direct inquiries regarding fiscal matters to:
Ms. Judy Musgrave
Office of Grants Management
National Center for Research Resources
6705 Rockledge Drive, Room 6205, MSC 7965
Bethesda, MD  20892-7965
Telephone:  (301) 435-0841
This program is described in the Catalog of Federal Domestic Assistance 
No.93.371, Biomedical Technology. Awards will be made under 
authorization of the Public Health Service Act, Title IV, Part A 
(Public Law 78-410, as amended by Public Law 99-158, 42 USC 241 and 
285) and administered under NIH grants policies and Federal Regulations 
42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the 
intergovernmental review requirements of Executive Order 12372 or 
Health Systems Agency review.
The DHHS strongly encourages all grant and contract recipients to 
provide a smoke-free workplace and promote the non-use of all tobacco 
products. In addition, Public Law 103-227, the Pro-Children Act of 
1994, prohibits smoking in certain facilities (or in some cases, any 
portion of a facility) in which regular or routine education, library, 
day care, health care or early childhood development services are 
provided to children. This is consistent with the DHHS mission to 
protect and advance the physical and mental health of the 
American people.

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