and Human Services (HHS)
EXPIRED
SMALL GRANT PROGRAM FOR THE NIDCR
Release Date: February 14, 2001
PA NUMBER: PAR-01-053
National Institute of Dental and Craniofacial Research
Application Receipt Dates: April 3 and August 3, 2001
December 3, 2001, April 3 and August 3, 2002
December 3, 2002, April 3 and August 3, 2003
THIS PA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES
DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED
WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS PA.
PURPOSE
This Program Announcement (PA) supersedes all previous announcements of the
National Institute of Dental and Craniofacial Research (NIDCR) Small Grant
(R03) Program under PA 91-036 (DE) and its extensions. The NIDCR Small Grant
(R03) Program has been modified to provide support ONLY to new investigators
for pilot research that is likely to lead to a subsequent Individual Research
Project Grant (R01) application. The research must be focused on one or more of
the areas within the biomedical and behavioral scientific mission of the NIDCR:
craniofacial anomalies and injuries, infectious diseases and immunity,
neoplastic diseases, chronic diseases, biomimetics, bioengineering, and tissue
engineering, and clinical, behavioral and health promotion research.
The Small Grant Program is designed to support basic and clinical research of
scientists who are in the early stages of establishing an independent research
career.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of "Healthy People 2010," a PHS-led national
activity for setting priority areas. This program announcement (PA) " SMALL
GRANT PROGRAM FOR THE NIDCR," is related to the priority area of Oral Health.
Potential applicants may obtain a copy of "Healthy People 2010" at:
http://www.health.gov/healthypeople.
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic for-profit and non-profit
organizations, public and private, such as universities, colleges, hospitals,
laboratories, units of state and local governments, and eligible agencies of
the Federal government. Racial/ethnic minority individuals, women, and persons
with disabilities are encouraged to apply. Foreign institutions and United
States organizations located in foreign countries are not eligible to apply for
this program.
Individuals defined as New Investigators and eligible for the NIDCR Small Grant
Program include former and current : (1) recipients of Individual Research
Career Development Awards, such as the Mentored Clinical Scientist Development
Award (K08), Scholar Development and Faculty Transition Award (K22) and the
Mentored Patient Oriented Research Career Development Award (K23), (2)
appointees in Institutional Research Career Development Award programs, such as
the Dentist Scientist Award (K16) and the Mentored Clinical Scientist
Development Program Award in Dental, Craniofacial and Oral Health Research
(K12), (3) recipients of individual National Research Service Awards (NRSA),
such as the Predoctoral Dental Science Fellowship (F30) and the Postdoctoral
Fellowship (F32) awards, and (4) trainees in the Institutional NRSA program
(T32). However, any current support by the F32 and T32 mechanisms must be
terminated before support in the NIDCR Small Grant Program begins.
Individuals who are current or previous recipients of NIH Research Project
Grants (R01, R03, R15, R21, R29, R55, P01, and P20) and Center Grants (P50 and
P60) as well as principal investigators of research subprojects of Program
Project (P01) and Center (P50 and P60) awards are not eligible for the R03
mechanism. Other NIH and Federal grant supported activities may also preclude
eligibility for this award. Potential applicants are advised to contact the
NIDCR program staff listed under INQUIRIES in order to ascertain eligibility
for this program. Individuals who are planning to re-enter research careers
and are ineligible for the R03 award as defined above should consider applying
under the NIH re-entry supplement program described in PA-99-106.
Only one small grant application from an individual Principal Investigator will
be considered by NIDCR per receipt date and only two revisions of a previously
reviewed small grant application may be submitted.
The work proposed may not overlap significantly with the aims of currently
supported projects in which the applicant has participated during the last five
years. However, the proposed work may be an extension of previously supported
projects in which the applicant has participated.
Applications for research focused on projects outside the NIDCR mission will
not be accepted for potential funding by NIDCR. Other questions about
eligibility may be directed to one of the program officials listed under
INQUIRIES.
MECHANISM OF SUPPORT
This program will use the NIH small grant (R03) award mechanism.
Responsibility for the planning, direction, and execution of the proposed
project will be solely that of the applicant. The total project period for an
application submitted in response to this PA may not exceed two years. The
NIDCR small grant is a $50,000 per year direct cost award. The Small Grant
funds may not be used to supplement projects currently supported by Federal or
non-Federal funds, or to support thesis or dissertation research. These grants
may not be renewed.
Specific application instructions have been modified to reflect "MODULAR GRANT"
and "JUST-IN-TIME" streamlining efforts being examined by the NIH. Complete
and detailed instructions and information on Modular Grant applications can be
found at: http://grants.nih.gov/grants/funding/modular/modular.htm.
RESEARCH OBJECTIVES
The R03 mechanism described in this program announcement will support research
and/or development relevant to all the branches, offices and programs of the
NIDCR Division of Extramural Research. The branches, offices and programs
comprising the Division of Extramural Research at NIDCR are described in more
detail on the website: http://www.nidcr.nih.gov/research/extramural/sciprog.htm
In brief, the different branches and offices at the NIDCR support research in:
(a) basic and clinical research on the processes that affect normal and
abnormal development of craniofacial structures, (b) basic studies on the
ecological, molecular, biological and physiological factors contributing to
microbial virulence, colonization and transmission, (c) sequence analysis of
the entire genome of oral microorganisms, (d) genetic determinants of host
susceptibility to infection, (e) basic and applied research related to oral
cancers, (f) basic and clinical studies on neurobiology, pathogenesis,
diagnosis, treatment or prevention of pain, (g) autoimmunity, (h) biomimetics,
tissue engineering, instrumentation development and refinement (i.e., saliva
based diagnostic technologies), and development of methods to improve
biomaterials for the repair of orofacial structures, and (i) clinical,
behavioral and health promotion studies related to craniofacial, oral and
dental health.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and their
sub-populations must be included in all NIH-supported biomedical and behavioral
research projects involving human subjects, unless a clear and compelling
rationale and justification are provided indicating that inclusion is
inappropriate with respect to the health of the subjects or the purpose of the
research. This policy results from the NIH Revitalization Act of 1993 (Section
492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in
Clinical Research," published in the NIH Guide for Grants and Contracts on
August 2, 2000
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html),
a complete copy of the updated Guidelines are available at
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: The
revisions relate to NIH defined Phase III clinical trials and require: a) all
applications or proposals and/or protocols to provide a description of plans to
conduct analyses, as appropriate, to address differences by sex/gender and/or
racial/ethnic groups, including subgroups if applicable, and b) all
investigators to report accrual, and to conduct and report analyses, as
appropriate, by sex/gender and/or racial/ethnic group differences.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by the
NIH, unless there are scientific and ethical reasons not to include them. This
policy applies to all initial (Type 1) applications submitted for receipt dates
after October 1, 1998.
All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH Guide for
Grants and Contracts, March 6, 1998, and is available at:
http://grants.nih.gov/grants/guide/notice-files/not98-024.html
URLs IN NIH GRANT APPLICATIONS OR APPENDICES
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH solicitation,
internet addresses (URLs) should not be used to provide information necessary
to the review because reviewers are under no obligation to view the Internet
sites. Reviewers are cautioned that their anonymity may be compromised when
they directly access an Internet site.
APPLICATION PROCEDURES
The research grant application form PHS 398 (rev. 4/98) is to be used in
applying for these grants with the modifications noted below. Application kits
are available at most institutional offices of sponsored research and may be
obtained from the Division of Extramural Outreach and Information Resources,
National Institutes of Health, 6701 Rockledge Drive, MSC-7910, Bethesda, MD
20892-7910, telephone 301/710-0267, email [email protected].
Application Instructions
The modular grant concept establishes specific modules in which direct costs
may be requested as well as a maximum level for requested budgets. Only
limited budgetary information is required under this approach. The just-in-
time concept allows applicants to submit certain information only when there is
a possibility for an award. It is anticipated that these changes will reduce
the administrative burden for the applicants, reviewers, and Institute staff.
The following instructions are to be used in conjunction with the information
accompanying application form PHS 398 (rev. 4/98), they refer only to selected
items in the application form. All PHS 398 requirements should be followed,
with the exception of those items affected by the following instructions.
Applications not conforming to the requested format will be returned to the
applicant without review.
FACE PAGE: Item 2, type "NIDCR Small Grant Program" in "Title" box, and check
the "YES" box, indicating response to Program Announcement.
Item 6: Up to a total of two years of support may be requested.
Items 7a and 7b: These items should be completed indicating Direct Costs
($50,000) and Total Costs [$50,000 plus Facilities and Administrative (F&A)
costs] for the initial budget period.
Items 8a and 8b: These items should be completed indicating the Direct (i.e.,
either $50,000 or $100,000) and Total Costs (i.e., either $50,000 or $100,000
plus F&A) for the entire proposed period of support.
DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD
Do not complete Form Page 4 of the PHS 398. It is not required and will not be
accepted with the application.
BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT
Do not complete the categorical budget table on Form Page 5 of the PHS 398. It
is not required and will not be accepted with the application.
NARRATIVE BUDGET JUSTIFICATION
Prepare a Modular Grant Budget Narrative page. For sample pages, see:
http://grants.nih.gov/grants/funding/modular/modular.htm.
At the top of the page, enter the total direct costs requested for each year
(i.e., $50,000). This is not a Form Page.
Under Personnel, list all project personnel, including their names, percent of
effort, and roles on the proposed project. Under the NIDCR Small Grant
Program, a minimum of 25% effort of the PI must be committed to the project.
The PI may request salary support, but significant justification together with
Institutional commitment should be provided. Salary support may also be
requested for technical support staff. No individual salary information should
be provided. However, the applicant should use the NIH appropriation language
salary cap and the NIH policy for graduate student compensation in developing
the budget request.
The Small Grant Program overall research budget may also include small
equipment, supplies, and travel. These grant funds may not be used to support
thesis or dissertation research.
For Consortium/Contractual costs, provide an estimate of total costs (direct
plus facilities and administrative) for each year, each rounded to the nearest
$1,000. List the individuals and organizations with whom consortium or
contractual arrangements have been made, the percent effort of all personnel,
and role on the proposed project. Indicate whether the collaborating
institution is foreign or domestic. The total cost for a
consortium/contractual arrangement is included in the overall requested $50,000
direct cost amount. Include the Letter of Intent to establish a consortium.
BIOGRAPHICAL SKETCH
The Biographical Sketch provides information used by reviewers in the
assessment of each individual"s qualifications for a specific role in the
proposed project, as well as to evaluate the overall qualifications of the
research team. A Biographical Sketch is required for all key personnel,
following the instructions below. No more than three pages may be used for
each person. A sample Biographical Sketch may be viewed at:
http://grants.nih.gov/grants/funding/modular/modular.htm.
o Complete the educational block at the top of the Form Page.
o List position(s) and then any honors.
o Provide information, including overall goals and responsibilities on
research projects ongoing or completed during the last three years and
identify all sources of previous and current research funding.
o List selected peer-reviewed publications with full citations.
OTHER SUPPORT
Do not complete this section. It is not required and will not be accepted with
the application.
RESEARCH PLAN
Do not exceed a total of 10 pages inclusive of the following sections:
Specific Aims, Background and Significance, Preliminary Studies/Progress Report
(or other evidence of feasibility), and Research Design and Methods. Pertinent
subject selection and recruitment information (e.g., inclusion of women,
minorities, children), as it impacts on study design, should also be included.
Tables, figures and photographs are included in the 10 page limitation.
For revised applications, an additional introduction (not to exceed one page)
is permitted. This introduction should respond to the comments and concerns of
the Initial Review Group delineated in the summary statement.
Applications that exceed the page limit or requirements for type size and
margins will be returned to the investigator. (Refer to PHS 398 application
for details.)
The 10 page limit does not include information regarding safety and ethical
issues related to subjects in research (Human Subjects, Inclusion of Children
as Participants in Research, Vertebrate Animals) or Consortia and Literature
Cited (Section E-I).
APPENDIX
Appendix materials may not be used to circumvent the page limitations.
However, letters of support may be used to describe the Institutional support
for the Principal Investigator (including salary and percent effort available
for research), to establish the Principal Investigator"s research as separate
and distinct from those of a former mentor, or to denote collaborative or
consultant relationships. Up to three publications, submitted manuscripts or
abstracts may also be included. Five copies of appendix materials should be
submitted. (Refer to PHS 398 application for additional Appendix guidelines.)
CHECKLIST
This page should be completed and submitted with the application. If the F&A
rate agreement has been established, indicate the type of agreement and the
date. All appropriate exclusions must be applied in the calculation of the F&A
costs for each budget period.
The applicant should provide the name and telephone number of the individual to
contact concerning fiscal and administrative issues if additional information
is required following initial review.
Use the mailing label in the application kit to mail the original and three
copies of the application to:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, SUITE 1040 - MSC-7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
To ensure that the application is received in sufficient time for the review,
send an additional two copies of the application to:
Chief, Scientific Review Branch
National Institute of Dental and Craniofacial Research
45 Center Drive, Room 4AN-44
Bethesda, MD 20892
Schedule
Application Receipt Dates: Dec 3, Apr 3, and Aug 3
NIDCR Committee Review: Feb/Mar, Jun/Jul, and Oct/Nov
Council Review: May, Oct, and Jan
Earliest Funding: Aug, Jan, and May
If the receipt date falls on a weekend, it will be extended to the following
Monday, if the date falls on a holiday, it will be extended to the following
business day.
The Center for Scientific Review (CSR) will not accept any application in
response to this PA that is essentially the same as one currently pending
initial review, unless the applicant withdraws the pending application. The
CSR will not accept any application that is essentially the same as one already
reviewed. This does not preclude the submission of substantial revisions of
applications already reviewed, but such applications must include an
introduction addressing the previous critique.
REVIEW CONSIDERATIONS
Applications will be reviewed for completeness and for responsiveness to this
PA by NIH staff. Incomplete and/or non-responsive applications may be returned
to the applicant without further consideration. Applications will be reviewed
for scientific and technical merit in accordance with the standard NIH
procedures by a scientific review group (SRG) convened by the NIDCR. As part
of the initial review, all applications will receive a written critique. Those
applications deemed to have the highest merit, generally the top-half of
applications under review, will be discussed, assigned a priority score, and
receive a second level of review by the NIDCR Advisory Council.
Review Criteria
The goals of NIH-supported research are to advance the understanding of
biological systems, improve the control of disease, and enhance health. In the
written review, comments on the following aspects of the application will be
made in order to judge the likelihood that the proposed research will have a
substantial impact on the pursuit of these goals. Each of these criteria will
be addressed and considered in the assignment of the overall score.
(1) Significance. Does this study address an important problem? If the aims
of the application are achieved, how will scientific knowledge be advanced?
What will be the effect of these studies on the concepts or methods that drive
this field?
(2) Approach. Are the conceptual framework, design, methods, and analyses
adequately developed, well integrated, and appropriate to the aims of the
project? Does the applicant acknowledge potential problem areas and consider
alternative tactics?
(3) Innovation. Does the project employ novel concepts, approaches or methods?
Are the aims original and innovative? Does the project challenge existing
paradigms or develop new methodologies or technologies?
(4) Investigator. Is the investigator appropriately trained and well suited to
carry out this work? Is the work proposed appropriate to the experience level
of the principal investigator and other researchers (if any)?
(5) Environment. Does the scientific environment in which the work will be
done contribute to the probability of success? Do the proposed experiments
take advantage of unique features of the scientific environment or employ
useful collaborative arrangements? Is there evidence of institutional support?
The initial review group will also examine the provisions for the protection of
human and animal subjects, the safety of the research environment, and
conformity with the NIH Guidelines for the Inclusion of Women and Children as
Subjects in Clinical Research.
AWARD CRITERIA
The awarding of grant funds is contingent on: (1) the receipt of applications
of high scientific merit, (2) responsiveness to this Program Announcement,
including the eligibility of investigators, (3) relevance to the mission of the
NIDCR, and (4) the availability of funds.
INQUIRIES
Inquiries concerning this program announcement are encouraged. The opportunity
to clarify any issues or questions from potential applicants is welcome.
Direct inquiries regarding programmatic issues to:
Dr. Rochelle K. Small
Craniofacial Anomalies and Injuries Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24K
Bethesda, MD 20892-6402
Phone: (301) 594-9898
Fax: (301) 480-8318
Email: [email protected]
Dr. Dennis Mangan
Infectious Diseases and Immunity Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-32F
Bethesda, MD 20892-6402
Telephone: (301) 594-2421
FAX: (301) 480-8318
Email: [email protected]
Dr. Ann Sandberg
Neoplastic Diseases Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24A
Bethesda, MD 20892-6402
Telephone: (301) 594-2419
FAX: (301) 480-8318
Email: [email protected]
Dr. Eleni Kousvelari
Biomaterials and Biomimetics and Tissue Engineering Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-18A
Bethesda, MD 20892-6402
Telephone: (301) 594-2427
FAX: (301) 480-8318
Email: [email protected]
Dr. Kenneth Gruber
Chronic Diseases Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-18C
Bethesda, MD 20892-6402
Telephone: (301) 594-4836
FAX: (301) 480-8318
Email: [email protected]
Dr. Norman Braveman
Office of Clinical, Behavioral and Health Promotion Research
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24C
Bethesda, MD 20892-6402
Telephone: (301) 594-2089
FAX: (301) 480-8318
Email: [email protected]
Dr. Maryann Redford
Director, Clinical Trials Program
Office of Clinical, Behavioral and Health Promotion Research
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24B
Bethesda, MD 2089-6402
Telephone:(301) 594-5588
FAX: (301) 480-8318
Email: [email protected]
Dr. Guo H. Zhang
Director, Salivary and Bone Research Program
Chronic Diseases Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-18B
Bethesda, MD 20892-6402
Telephone: (301) 594-0618
FAX: (301) 480-8318Phone:
Email: [email protected]
Dr. Patricia Bryant
Director, Behavioral and Health Promotion Research Program
Office of Clinical, Behavioral and Health Promotion Research
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-24E
Telehone: (301) 595-2095
FAX: (301) 480-8318
Bethesda, MD 20892
Email: [email protected]
Direct inquiries regarding fiscal matters to:
Mr. Martin Rubinstein
Grants Management Branch
National Institute of Dental and Craniofacial Research
Natcher Building, Room 4AN-44A
Bethesda, MD 20892-6402
Telephone: (301) 594-4800
FAX: (301) 480-8301
Email: [email protected]
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.121, Oral Diseases and Disorders Research Awards. Awards are made under
authorization of the Public Health Service Act, Title IV, Part A (Public Law
78-410, as amended by Public Law 99-158, 42 USC 241 and 285) and administered
under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74
and 92. This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products. In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, and portion of a facility) in which
regular or routine education, library, day care, health care or early childhood
development services are provided to children. This is consistent with the PHS
mission to protect and advance the physical and mental health of the American
people.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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