AHRQ SMALL RESEARCH GRANT PROGRAM
Release Date: January 2, 2001
PA NUMBER: PAR-01-040
Agency for Healthcare Research and Quality (formerly AHCPR)
Application Receipt Dates: March 24th, July 24th, November 24th
March 2, 2006 (NOT-OD-06-046) Effective with the June 1, 2006 submission date,
all R03, R21, R33 and R34 applications must be submitted through Grants.gov using
the electronic SF424 (R&R) application. This announcement will stay active for
only the May 1, 2006 AIDS and AIDS-related application submission date. The
non-AIDS portion of this funding opportunity expires on the date indicated below.
A replacement R03 (PAR-06-448) funding opportunity announcement has been issued
for the submission date of June 1, 2006 and submission dates for AIDS and
non-AIDS applications thereafter.
EXPIRATION DATE for R03 Non-AIDS Applications: March 2, 2006
EXPIRATION DATE for R03 AIDS and AIDS-Related Applications: May 2, 2006
(Expiration date previously extended, see NOT-HS-05-007)
PURPOSE
The mission of the Agency for Healthcare Research and Quality (AHRQ),
formerly known as the Agency for Health Care Policy and Research (AHCPR), is
to enhance the quality, appropriateness, and effectiveness of health
services, and access to such services, through the
establishment of a broad base of scientific research and through the
promotion of improvements in clinical and health systems practices, including
the prevention of diseases and other health conditions. AHRQ achieves this
mission through health services research designed to (1) improve clinical
practice, (2) improve the health care system’s ability to provide access to
and deliver high quality, high-value health care, and (3) provide
policymakers with the ability to assess the impact of system changes on
outcomes, quality, access to, cost, and use of health care services.
AHRQ’s research agenda is designed to be responsive to the needs of
consumers, patients, clinicians and other providers, institutions, plans,
purchasers, and public policymakers for the evidence-based information they
need to improve quality and outcomes, control costs, and assure access to
needed services. AHRQ is especially interested in research involving
collaborative efforts between researchers and medical and public health or
healthcare provider, purchasers or payer organizations.
AHRQ announces a program of small research grants designed to provide support
for new investigators or researchers new to health care services issues and
encourage preliminary, exploratory, or innovative research in new or
previously unexamined areas.
This announcement replaces the following earlier announcements: 1) AHCPR
Small Project Grant Program, published in the NIH Guide for Grants and
Contracts on February 23, 1996, 2) AHCPR Small Project Grant Program -
Addendum, published also in the Guide, on January 29, 1999, and 3) AHRQ
Small Research Grant Program Addendum, published in the Guide on July 13,
2000.
HEALTHY PEOPLE 2010
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of Healthy People 2010, a PHS-
led national activity for setting health improvement priorities for the
United States. AHRQ encourages applicants to submit grant applications with
relevance to the specific objectives of this initiative. Potential
applicants may obtain a copy of Healthy People 2010" at
http://www.health.gov/healthypeople/
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic public or private non-profit
organizations, including universities, clinics, units of State and local
governments, and nonprofit firms and foundations. For the purpose of this
PA, AHRQ, by statute, can award grants only to non-profit organizations.
Organizations described in section 501(c)4 of the Internal Revenue Code that
engage in lobbying are not eligible.
AHRQ encourages investigators who are women, members of racial and ethnic
minority groups, and persons with disabilities to apply as Principal
Investigators.
AHRQ also encourages new investigators (as defined in the PHS 398 application
instructions) to apply as Principal Investigators.
Projects must be self-contained. They may be conceptually linked to future
or past projects but must contain all the elements of a stand-alone effort
that can be reviewed and evaluated on its own for both scientific merit and
budget.
The request may not be used to supplement currently supported projects,
provide interim support for projects under review by the PHS, or obtain
funding as a competing continuation of a small grant. Requests for support
for dissertation research will not be considered under this small grant
program. Applications to support dissertations should be submitted for
consideration under the AHRQ Small Grant Program for Health Services
Dissertation Research (see Inquiries ).
MECHANISM OF SUPPORT
Grants provided under this Program Announcement (PA) will use the small
research grant (R03) mechanism. Responsibility for the planning, direction,
and execution of the proposed project will be solely that of the proposed
Principal Investigator. The budget limit on small project grant applications
is $100,000 total costs (i.e., direct costs plus facilities and
administrative
costs) for the entire project period. Projects may not exceed $100,000 in
total costs. Grant support will normally not exceed 24months.
RESEARCH OBJECTIVES
Background
Title IX of the Public Health Service (PHS) Act (42 U.S.C. 299 et seq.
amended, Sec. 922) gives AHRQ flexibility in review procedures for awarding
small grants. AHRQ uses the small grant authority to support three kinds of
activities: conferences, doctoral dissertations, and small research grants.
This Program Announcement describes the third of these activities, the AHRQ
Small Research Grant Program. Under this program, AHRQ provides support for
focused, developmental, and innovative research projects.
Focused Research Projects
Projects can be descriptive or involve the testing of hypotheses. Projects
must be discrete, that is, only projects that can be completed within the
budgetary and time constraints imposed by the small grant program are
eligible for support. Projects can use any of a variety of methods:
opportunistic, qualitative research, quantitative analysis of existing
secondary data, policy research, evaluations of demonstrations or programs,
case studies, historical, legal, or ethical analysis, or primary data
collection and analysis.
Developmental Research Studies
Developmental projects can involve feasibility studies or pilot projects.
They can also include formative or exploratory activities such as
construction or modification of a survey instrument, research to test the
design of a large-scale study, and collection and analysis of quantitative or
qualitative information for the purpose of hypothesis generation.
Innovative Research Projects
Innovative projects involve the study of a novel issue or problem or the
application of a novel methodological approach. These projects might employ
techniques or theories from other fields not traditionally linked to health
services research. Such projects have the potential for providing new
insights into methodological or substantive issues. Because these projects
may be groundbreaking, there is also a greater probability than with more
conventional projects that they may not achieve the desired or planned
outcome.
New Investigators
Although the focus of this Program is research, the Program also provides an
opportunity for new investigators to submit applications or for established
investigators to explore health care research issues in fields other than
their primary area of research interest. AHRQ encourages submission of
applications from such investigators.
Research Priorities
The following topics represent areas of research that the Agency is most
interested in.
o Accelerating and magnifying the impact of research on clinical practice
and patient outcomes in applied settings.
o Demonstrating that the translation of research into practice leads to
measurable and sustainable improvements in health care.
o Understanding how research and cost-effectiveness analysis is used in
decision making by health care policymakers, administrators, and managers.
Of particular interest are studies that enhance our understanding the ethical
implications of the use of cost-effectiveness analysis by health care
decision-makers.
o Developing strategies to incorporate individuals values and equity
considerations into cost-
effectiveness analyses.
o Improving the health care system’s ability to provide access to and
deliver high quality, high-
value health care.
o Developing and evaluating decision support systems to support real-time
detection of bioterrorist threats and management of bioterrorism.
o Eliminating inequality in quality and outcomes associated with race and
ethnicity.
o Assessing the quality of care for vulnerable populations.
o Evaluating quality and patient safety in ambulatory care.
o Enhancing informed decision-making in primary care settings, including
shared patient-
clinician decision-making.
o Using clinical informatics to improve primary care practice, including
evaluation of its impact on quality, outcomes, cost and patient satisfaction.
o Assessing the organization and delivery of preventive care and methods to
improve both the amount and quality of clinical preventive services that are
delivered.
o Understanding the determinants of insurance coverage and access to care.
o Improving methodologies to systematically review and evaluate preventive
services, especially screening tests.
o Improving the delivery of primary care services in rural and inner-city
areas.
o Assessing the special health care needs of low income populations.
o Improving care at the end-of-life.
o Providing policy makers with the ability to assess the impact of health
care changes on outcomes, effectiveness, quality, access, cost and use of
health services.
o Developing methods and measures for identifying and preventing medical
errors to enhance patient safety.
o Evaluating the impact of chronic illness among workers and their
dependents on health care outcomes and work productivity.
o Developing methodological advances in health services research,
especially cost-effectiveness analysis.
o Assessments of the structure and effects of new, complex plan and
provider organizations.
o Providing empirical evidence about new models of incentive-driven
behavior that will improve our understanding of health care markets in
policy-relevant ways.
o Providing evidence-based insight into the nature, extent, and
effectiveness of value-based purchaser behavior.
In all of the topics listed above the Agency is interested in an explicit
focus on priority populations, which include low-income groups, minority
groups, women, children, the elderly and those with special needs, and health
care delivery in inner-city and rural areas.
SPECIAL REQUIREMENTS
Allowable Costs and Unallowable Costs
Expenses allowed under the AHRQ Small Project Grant Program follow the
guidelines described in the Application for a Public Health Service Grant
(Form PHS 398, rev. 4/98) with some exceptions.
Direct Cost Expenditures
Equipment. It is not the intent of this program that funds be used to
purchase equipment. With strong justification, however, funds may be
approved for this purpose.
Supplies. With strong justification, grant funds may be used for the purchase
of supplies. These supplies must be received and used during the project
period.
Alterations and Renovations. Grant funds may not be used to support facility
alteration or renovation of any kind.
Subcontracts: Grant funds may be used for subcontracts, but not to the
extent of exceeding funds budgeted for the grantee. The grantee, as the
direct and primary recipient of grant funds, must perform a substantive role
in carrying out project activities and not merely serve as a conduit for an
award to another party or to provide funds to an ineligible party.
Facilities and Administrative (F&A) Costs (Indirect Costs)
Facilities and Administrative (F&A) Costs (F&A Costs are synonymous with
indirect costs ) are allowable and will be calculated using the negotiated
F&A cost rate agreement in effect at the time of the initial Notice of Grant
Award.
Data Privacy
Pursuant to section 903(c) of the Public Health Service Act (42 USC 299a-
1(c)), information obtained in the course of any AHRQ-supported study that
identifies an individual or entity must be treated as confidential in
accordance with any promises made or implied regarding the use and purposes
of the data collection. Applicants must describe in the Human Subjects
section of the application procedures for ensuring the confidentiality of
such identifying information. The description of the procedures should
include a discussion of who will be permitted access to the information, both
raw data and machine readable files, and how personal identifiers and other
identifying or identifiable data will be safeguarded.
The grantee should ensure that computer systems containing confidential data
have a level and scope of security that equals or exceeds those established
by the Office of Management and Budget (OMB) in OMB Circular No. A-130,
Appendix III - Security of Federal Automated Information Systems. The
National Institute of Standards and Technology (NIST) has published several
implementation guides for this circular. They are: An Introduction to
Computer Security: The NIST Handbook, Generally Accepted Principals and
Practices for Securing Information Technology Systems, and Guide for
Developing Security Plans for Information Technology Systems. The circular
and guides are available on the web at
http://csrc.nist.gov/publications/nistpubs/800-12/handbook.pdf.
Rights in Data
AHRQ grantees may copyright or seek patents, as appropriate, for final and
interim products and materials including, but not limited to, methodological
tools, measures, software with documentation, literature searches, and
analyses, which are developed in whole or in part with AHRQ funds. Such
copyrights and patents are subject to a Federal government license to use
these products and materials for AHRQ purposes. In accordance with its
legislative dissemination mandate, AHRQ purposes may include, subject to
statutory confidentiality protections, making research materials, data bases,
and algorithms available for verification or replication by other
researchers, and subject to AHRQ budget constraints, final products maybe
made available to the health care community and the public by AHRQ, or its
agents, if such distribution would significantly increase access to a product
and thereby produce public health benefits. Ordinarily, to accomplish
distribution, AHRQ publicizes research findings but relies on grantees to
publish in peer-reviewed journals and to market grant-supported products.
INCLUSION OF WOMEN, MINORITIES, AND CHILDREN IN RESEARCH STUDY POPULATIONS
It is the policy of AHRQ that women and members of minority groups be
included in all AHRQ-
supported research projects involving human subjects, unless a clear and
compelling rationale and justification are provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of
the research.
All investigators proposing research involving human subjects should read the
UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in
Clinical Research," published in the NIH Guide for Grants and Contracts on
August 2, 2000
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html),
a complete copy of the updated Guidelines are available at
http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: The
revisions relate to NIH defined Phase III clinical trials and require: a) all
applications or proposals and/or protocols to provide a description of plans
to conduct analyses, as appropriate, to address differences by sex/gender
and/or racial/ethnic groups, including subgroups if applicable, and b) all
investigators to report accrual, and to conduct and report analyses, as
appropriate, by sex/gender and/or racial/ethnic group differences.
To the extent possible, AHRQ requires adherence to these NIH Guidelines.
Investigators may obtain copies from the above sources or from the AHRQ
Publications Clearinghouse, listed under INQUIRIES, or from the NIH Guide Web
site http://grants.nih.gov/grants/guide/index.html.
AHRQ also encourages investigators to consider including children in study
populations, as appropriate.
AHRQ program staff may also provide additional information concerning these
policies (see INQUIRIES).
APPLICATION PROCEDURES
Applications are to be submitted on the research grant application form PHS
398 (rev.4/98). State and local government applicants may use PHS 5161-1,
Application for Federal Assistance (rev.5/96), and follow those requirements
for copy submission. Applicants are encouraged to read all PHS Form 398
instructions prior to preparing an application in response to this PA.
Application kits are available at most institutional offices of sponsored
research or from the Division of Extramural Outreach and Information
Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910,
Bethesda, MD 20982-7910, telephone (301)710-0267, email: grantsInfo@nih.gov
.
AHRQ applicants are encouraged to obtain application materials from the AHRQ
Publications Clearinghouse (see INQUIRIES).
On line 2 of the face page of the application, mark the yes box and type
the PA number and title in the space provided.
AHRQ encourages applicants to review all application form 398 instructions
prior to completing an application. The PHS 398 type size requirements (p.6)
will be enforced rigorously and non-
compliant applications will be returned.
Receipt dates for small research grant applications are three times annually:
March 24th, July 24th, and November 24th.
Application Preparation (for Using HCFA Data)
For applications that propose to use Medicare or Medicaid data that are
individually identifiable, applicants should state explicitly in the Research
Design and Methods section of the Research Plan (form 398) the specific
files, time periods, and cohorts proposed for the research. In consultation
with the Health Care Financing Administration (HCFA), AHRQ will use this
information to develop a cost estimate for obtaining the data. This estimate
will be included in the estimated total cost of the grant at the time funding
decisions are made. To avoid double counting, applicants should not include
the cost of the data in the budget. Small research grant applicants should
be aware that the costs of the grant, including the cost of HCFA data, can
not exceed $100,000 total costs. In the event the total costs of the project
plus the cost of HCFA data is greater than $100,000, the budget for the
project will be adjusted so that the total costs awarded to the recipient
plus the HCFA data costs do not exceed $100,000.
Applicants should be aware that for individually identifiable Medicare and
Medicaid data, Principal Investigators and their grantee institutions will be
required to enter into a Data Use Agreement (DUA) with HCFA to protect the
confidentiality of data in accordance with standards set out in OMB Circular
A-130, Appendix III Security of Federal Automated Information Systems. The
use of the data is restricted to the purposes and time period specified in
the DUA. At the end of this time period, the grantee is required to return
the data to HCFA or certify that the data have been destroyed.
Grantees must also comply with the confidentiality requirements of Section
903(c) of the PHS Act. See the Data Privacy section for details on these
requirements as well as references to Circular A-130 and its implementation
guides from the National Institute of Standards and Technology.
In developing research plans, applicants should allow time for refining,
approving, and processing their data requests. Requests may take 6 months
from the time they are submitted to complete. Applications proposing to
contact beneficiaries or their providers require the approval of the HCFA
Administrator and may require meeting(s) with HCFA staff.
HCFA data are provided on IBM mainframe tapes using the record and data
formats commonly employed on these computers. Applicants should either have
the capability to process these tapes and formats or plan to make
arrangements to securely convert them to other media and formats.
Questions regarding HCFA data should be directed to the AHRQ program official
listed under INQUIRIES.
AHRQ Data
AHRQ encourages research applications that will use data from the Medical
Expenditures Panel Survey, or MEPS (http://www.meps.ahrq.gov/), the
Healthcare Cost and Utilization Project, or HCUP-3
(http://www.meps.ahrq.gov/Data_Public.htm), and other AHRQ sources.
MEPS is a rich data source for healthcare utilization, expenditure, and
insurance information. MEPS directly links data about persons and their
families with information obtained from their employers, insurers, and
healthcare providers. It is the third in a series of nationally
representative surveys of medical care use and expenditures in the United
States. Unlike its predecessors, MEPS is an ongoing survey. MEPS collects
data on the specific health services that Americans use, how frequently they
use them, the cost and source of payment for services, and information on the
types and costs of private health insurance held by and available to the U.S.
population. It provides a foundation for estimating the impact of changes in
sources of payment and insurance coverage on different economic groups or
special populations of interest, such as the poor, elderly, uninsured, and
racial and ethnic minorities. Current information on the availability of MEPS
data is on the MEPS section of the AHRQ Web site (http://www.ahrq.gov).
The HCUP includes databases covering 1988-1997, with 1998 and 1999 data
available in 2001. These all-payer databases were created through a Federal-
state-industry partnership to build a multistate health care data system.
The main HCUP databases contain discharge-level information for inpatient
hospital stays in a uniform format with privacy protections. The Nationwide
Inpatient Sample (NIS) is a nationwide probability sample of about 1000
hospitals. The State Inpatient Databases (SID) contain inpatient records for
all community hospitals in 22 states. Other HCUP databases contain
ambulatory surgery data from nine states. These databases can be directly
linked to county-level data from the Health Resources and Services
Administration"s Area Resource File and to hospital-level data from the
Annual Survey of the American Hospital Association.
Special Application Instructions
Specific Instructions for Form 398 (rev.4/98) are to be followed, with the
following exceptions:
o The section entitled Research Plan must not exceed 15 pages in length.
Applicants determine the appropriate length of the areas that must be
addressed in the Research Plan, but the statement must not exceed the 15
page limit.
o In listing references, only literature immediately relevant to the
application may be cited. The reference list is not counted as part of the
15 pages allotted for the Research Plan.
o No appendices should be included with the application with the exception
of proposed instruments. These should be attached only if they are judged to
be crucial for the review of the project. The instruments will not count as
part of the 15 pages.
o If applicable, information such as letters of support, letters of
participation, and statements of intent to establish a consortium can be
placed directly before the Checklist page of the application.
o Submit a signed, typewritten original of the application, including the
checklist, and five signed photocopies, in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040-MSC 7710
Bethesda, MD 29892-7710
(20817 for express/courier service)
REVIEW CONSIDERATIONS
Upon receipt, applications will be reviewed for completeness and
responsiveness to the PA by AHRQ staff. Incomplete and/or non-responsive
applications or applications not following instructions given under
Application Procedures will be returned to the applicant without further
consideration. Accepted applications will be evaluated for scientific and
technical merit by an appropriate peer review group convened in accordance
with standard AHRQ peer review procedures.
As part of the peer review, all applications will receive a written critique,
and also may undergo a process in which only those applications deemed to
have the highest scientific merit will be discussed and assigned a priority
score.
Review Criteria
The review criteria for AHRQ grant applications are:
o Significance and originality of the project.
o Adequacy of the proposed methods.
o Availability of data or adequacy of plan to collect data.
o Adequacy of plans for organizing and carrying out the project.
o Qualifications and experience of the investigators.
o Adequacy of facilities and resources for the project.
o Human subjects involvement and protection (when appropriate).
o Representation of women and minorities (when appropriate).
o Reasonableness of budget and time frame relative to proposed work.
AWARD CRITERIA
AHRQ sets aside funding each fiscal year for the Small Research Grant
Program. The amount of the set-aside is dependent upon the availability of
funds.
In making funding decisions for small grants, the reviewers" assessment of
technical merit is important, but is not the only factor used to determine
which applications will be funded. Additional factors include the focus of
the project, potential significance of the study, and the overall
contribution the project will make to the field of health services research.
The earliest possible date of award is 5 months after the receipt of the
application by AHRQ.
Applications not selected for funding under AHRQ"s Small Research Grant
Program may be revised and resubmitted once for review and funding
consideration. At AHRQ"s discretion, efforts may be made to resolve problems
in applications deemed to hold promise. Applicants should not assume on the
basis of efforts to resolve such problems that AHRQ is committed to making an
award.
To receive an award, applicants must agree to submit an original and 2 copies
of an abstract, executive summary, and full report of the research results in
the format prescribed by AHRQ no later than 90 days after the end of the
project period. The executive summary should be sent at the same time on a
computer disk which specifies on the label the format used (WP5.1 or WP6.0 is
preferable).
Applicants must also agree to notify AHRQ immediately when a manuscript based
on research supported by the grant is accepted for publication, and to
provide the expected date of publication as soon as it is known, regardless
of whether or not the grant award is active or has ended.
INQUIRIES
Copies of the PA are available from:
AHRQ Publications Clearinghouse
P.O. Box 8547
Silver Spring, MD 20907-8547
Telephone: 1-800-358-9295
TDD Service: 888-586-6340
This PA is also available on the AHRQ Web site (http://www.ahrq.gov), and
through AHRQ InstantFAX at (301) 594-2800. To use InstantFAX, you must call
from a facsimile (FAX) machine with a telephone handset. Follow the voice
prompt to obtain a copy of the table of contents, which has the document
order number (not the same as the RFA number). The PA will be sent at the
end of the ordering process. AHRQ InstantFAX operates 24 hours a day, 7 days
a week. For comments or problems concerning AHRQ InstantFax, please call
(301) 594-6344.
The AHRQ Web site (http://www.ahrq.gov) also provides information on other
grant solicitations and announcements (click on Funding Opportunities ).
AHRQ welcomes the opportunity to clarify any issues or questions from
potential applicants who have read the PA. Written and telephone inquiries
concerning this PA are encouraged. Direct inquiries regarding programmatic
issues, including information on the inclusion of women, minorities, and
children in study populations to:
Primary Care Research
Kelly Morgan
Telephone: (301) 594-1782
e-mail: kmorgan@ahrq.gov
Outcomes and Effectiveness Research
Joanne Book
Telephone: (301) 594-4039
e-mail: jbook@ahrq.gov
Cost, Financing, and Market Forces
Achintya Dey
Telephone: (301) 594-0890
e-mail: adey@ahrq.gov
Organization and Delivery
Irene Fraser, PhD
Telephone: (301) 594-6768
e-mail: ifraser@ahrq.gov
Quality Improvement and Patient Safety
Elinor Walker
Telephone: (301) 594-2049
e-mail: ewalker@ahrq.gov
Inquiries Regarding AHRQ Data Sources
MEPS Household Component
Nancy Krauss
Telephone: (301) 594-0846
e-mail: nkrauss@ahrq.gov
MEPS Nursing Home Component
Jeffrey Rhoades, PhD
Telephone: (301) 594-0891
e-mail: jrhoades@ahrq.gov
HIV Cost and Services Utilization Study
Doris Lefkowitz, PhD
Telephone: (301) 594-1077
e-mail: dlefkowi@ahrq.gov
HCUP-3
Kelly Carper
Telephone: (301) 594-3075
e-mail: kcarper@ahcpr.gov or hcupnis@ahcpr.gov or hcupsid@ahcpr.gov
Direct Inquiries Regarding Fiscal and Eligibility Matters to:
Michelle Burr
Telephone: (301) 594-1840
e-mail: mburr@ahrq.gov
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.226. Awards are made under authorization of Section 901(b), 902(c), and
925(c) of the Public Health Service Act, as amended (42 USC 299-299c-6).
Awards are administered under the PHS Grants Policy Statement and Federal
Regulations 42 CFR 67, Subpart A, and 45 CFR Parts 74 and 92. This program
is not subject to the intergovernmental review requirements of Executive
Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products. In
addition, Public Law 103-227, the Pro-
Children Act of 1994, prohibits smoking in certain facilities (or in some
cases, any portion of a facility) in which regular or routine education,
library, day care, health care or early childhood development services are
provided to children. This is consistent with the PHS mission to protect and
advance the physical and mental health of the American people.
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