and Human Services (HHS)
EXPIRED
THE HOWARD TEMIN AWARD
Release Date: February 22, 2000 (see replacement PAR-03-104)
PA NUMBER: PAR-00-066
National Cancer Institute
This program announcement (PA) replaces PAR-99-063, which was published in
the NIH Guide on February 12, 1999
PURPOSE
The goal of the National Cancer Institute's (NCI) Howard Temin Award is to
bridge the transition from a mentored research environment to an independent
research career for scientists who have demonstrated unusually high potential
during their initial stages of training and development. This special award
is aimed at fostering the research careers of outstanding junior scientists
in basic research who are committed to developing research programs directly
relevant to the understanding of human biology and human disease as it
relates to the etiology, pathogenesis, prevention, diagnosis, and treatment
of human cancer. The major objective of the award is to sustain and advance
the early research careers of the most promising M.D.s and Ph.D.s while they
consolidate and focus their independent research programs, and obtain their
own research grant support. To achieve this objective, the Howard Temin
Award offers candidates up to five years to develop knowledge in the basic
sciences and research skills relevant to the candidate's career goals, with
up to three of the initial years (at least one year required) in a mentored
environment followed by a transition to an unmentored independent
investigator phase for the remaining time on the award.
HEALTHY PEOPLE 2000
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000," a
PHS-led national activity for setting priority areas. This PA, "The Howard
Temin Award", is related to the priority area of cancer and human resource
development. Potential applicants may obtain a copy of "Healthy People 2000"
at (http://odphp.osophs.dhhs.gov/pubs/hp2000).
ELIGIBILITY REQUIREMENTS
Applicants are encouraged to contact the NCI program staff listed under
INQUIRIES regarding their eligibility for this award prior to the preparation
of an application.
The candidate must have a research or a health professional doctorate or its
equivalent, must have completed at least three years of postdoctoral research
at the time of award, and must have demonstrated highly productive research
activity and the potential for establishing an independent research program
in the period after the doctorate. Recipients of an NCI Preventive
Oncology/Population Sciences Career Development (K07) Award, a Mentored
Clinical Research Scientist Career Development (K08) Award or a Mentored
Patient-Oriented Research Career Development (K23) Award who are in their
last two years of support are also eligible to apply. The career development
award will be terminated upon acceptance of a Howard Temin Award.
Candidates must be able to identify an individual who can serve as a mentor
for some portion of the initial mentored phase of this award.
Former or current principal investigators on NIH Small Grants (i.e., R03s) or
Exploratory/Developmental Grants (i.e., R21s) remain ELIGIBLE to apply.
However, former or current principal investigators on NIH research projects
(i.e., R01s), FIRST Awards (i.e., R29s), sub-projects on Program Project
Grants (i.e., P01s) or center grants (i.e., P50s) and their equivalents are
NOT ELIGIBLE.
Applications may be submitted, on behalf of candidates, by domestic,
non-Federal organizations, public or private, such as medical, dental, or
nursing schools or other institutions of higher education. Racial/ethnic
minority individuals, women, and persons with disabilities are encouraged to
apply as principal investigators. Candidates must be U.S. citizens or
non-citizen nationals, or must have been lawfully admitted for permanent
residence by the time of award. Individuals admitted for permanent residence
must be able to produce documentation of their immigration status such as an
Alien Registration Receipt Card (I-151 or I-551) or some other verification
of legal admission as a permanent resident. Non-citizen nationals, although
not U.S. citizens, owe permanent allegiance to the U.S. They are usually
born in lands that are not states but are under U.S. sovereignty,
jurisdiction, or administration. Individuals on temporary or student visas
are not eligible for this award.
MECHANISM OF SUPPORT
This PA will use the National Institutes of Health (NIH) K01 mechanism. The
total project period for an application submitted in response to this PA may
not exceed 5 years. The actual length of the awarded project period will
depend upon the number of years of prior research experience and the need for
additional experiences to achieve independence. Planning, direction, and
execution of the program will be the responsibility of the candidate and
her/his mentor on behalf of the applicant institution. Awards are not
renewable.
FUNDS AVAILABLE
The Howard Temin award is a highly competitive award, with the intent of
providing support to outstanding junior scientists during their transition to
an independent investigator status.
RESEARCH OBJECTIVES
A. Purpose: The National Cancer Institute is interested in encouraging basic
scientists to become more interested in research problems of high relevance
to human biology particularly as they relate to the etiology, pathogenesis,
prevention, diagnosis, control and treatment of human cancer. In the past,
the major effort of the NCI has been to encourage medically trained
individuals to become interested in basic research problems at the most
fundamental biological levels, but there has been no effort to encourage
scientists trained in the basic sciences to focus on problems of direct
relevance to the clinical sciences or the prevention, control and population
sciences. The continued success of future cancer research will depend upon
the increased ability of the cancer biomedical research community to
effectively translate observations in the laboratory into patient and
population research settings. Well-trained basic scientists who focus their
research on human biology and human disease will be an essential component of
the translational research enterprise. The Howard Temin Award not only
offers continuing encouragement to clinicians for training in basic research,
but additionally represents a complementary new effort to encourage
scientists trained in the basic sciences to focus on problems of direct high
relevance to the clinical sciences or the prevention, control and population
sciences as they relate to cancer. Specifically, the Howard Temin Award
provides an opportunity for medically trained individuals and basic
scientists to initially work under a mentor in an institutional environment
that will enable them to transition to an independent research position and
acquire research support focused on issues and problems directly relevant to
human cancer.
B. Environment: The institution must have a well-established basic research
and/or clinical career development program(s) and qualified faculty to serve
as mentors. The candidate, mentor and institution must be able to describe a
multi-disciplinary career development program in basic research that will
maximize the use of relevant research and educational resources.
C. Program: The award provides up to five consecutive 12 month appointments.
At least 75 percent of the recipient's full-time professional effort must be
devoted to the program and the remainder devoted to other research-related
and/or teaching pursuits consistent with the objectives of the award. The
candidate must develop knowledge in the basic sciences and research skills
relevant to his or her career goals. The candidate may find it appropriate
to include relevant didactic and laboratory or field research experiences.
D. Mentor(s): The recipient must receive appropriate mentoring during some
fraction of the first three years of the initial phase of the award. The
candidate may move to an unmentored research environment only on the award
anniversary dates of the second, third and fourth year of support. See the
SUPPLEMENTAL GUIDELINES FOR TRANSITION TO THE UNMENTORED STATE below. The
transition must take place no later than the end of the third year. The
transition application Where feasible, women and minority mentors should be
involved as role models.
E. Allowable Costs:
1. Salary: The Temin award will provide salary up to $75,000 plus fringe
benefits. The total salary requested must be based on a full-time, 12 month,
staff appointment requiring the candidate to spend a minimum of 75 percent
effort conducting cancer research with the remaining effort being devoted to
activities related to the development of a successful research career. The
salary must be consistent both with the established salary structure at the
institution and with salaries actually provided by the institution from its
own funds to other staff members of equivalent qualifications, rank, and
responsibilities in the department concerned. If full-time, 12 month
salaries are not currently paid to comparable staff members, the salary
proposed must
be appropriately related to the existing salary structure.
2. Research Development Support: During the mentored phase of the award,
$30,000 per year will be provided for the following types of expenses: (a)
research expenses, such as supplies, equipment, and technical personnel; (b)
statistical services including personnel and computer time; (c) tuition,
fees, and books related to career development; and (d) travel to research
meetings or for training. The amount of this support will increase to
$50,000 when the principal investigator transitions to an independent
research position either at the same institution or at a different
institution.
3. Ancillary Personnel Support: Salary for mentors, secretarial and
administrative assistance, etc. is not allowed.
4. Facilities and Administrative Costs: These costs, which were formerly
called indirect costs, will be reimbursed at 8 percent of modified total
direct costs.
F. Evaluation: In carrying out its stewardship of human resource related
programs, the NIH may begin requesting information essential to an assessment
of the effectiveness of this program. Accordingly, recipients are hereby
notified, that they may be contacted after the completion of this award for
periodic updates on various aspects of their employment history,
publications, support from research grants or contracts, honors and awards,
professional activities, and other information helpful in evaluating the
impact of the program.
G. Other Income: Fees resulting from clinical practice, professional
consultation, or other comparable activities required by the research and
research-related activities of this award may not be retained by the career
award recipient. Such fees must be assigned to the grantee institution for
disposition by any of the following methods:
o The funds may be expended by the grantee institution in accordance with the
NIH policy on supplementation of career award salaries and to provide fringe
benefits in proportion to such supplementation. Such salary supplementation
and fringe benefit payments must be within the established policies of the
grantee institution;
o The funds may be used for health-related research purposes;
o The funds may be paid to miscellaneous receipts of the U.S. Treasury.
Checks should be made payable to the Department of Health and Human Services,
NIH and forwarded to the Director, Office of Financial Management, NIH,
Bethesda, Maryland 20892. Checks must identify the relevant award account
and reason for the payment;
o Awardees may retain royalties and fees for activities such as scholarly
writing, service on advisory groups, or honoraria from other institutions for
lectures or seminars, provided these activities remain incidental and
provided that the retention of such pay is consistent with the policies and
practices of the grantee institution.
Usually, funds budgeted in an NIH supported research or research training
grant for the salaries or fringe benefits of individuals, but freed as a
result of a career award, may not be rebudgeted. The awarding component will
give consideration to approval for the use of released funds only under
unusual circumstances. Any proposed retention of funds released as a result
of a career award must receive prior written approval of the NIH awarding
component.
H. Special Leave: Leave to another institution, including a foreign
laboratory may be permitted if the proposed experience is directly related to
the purpose of the award. Only local, institutional approval is required if
such leave does not exceed 3 months. For longer periods, prior written
approval of the NIH funding component is required. To obtain prior approval,
the award recipient must submit a letter to the NIH funding component
describing the plan, countersigned by his or her department head and the
appropriate institutional official. A copy of a letter or other evidence
from the institution where the leave is to be taken must be submitted to
assure that satisfactory arrangements have been made. Support from the
career award will continue during such leave.
Leave without award support may not exceed 12 months. Such leave requires
the prior written approval of the NIH funding component and will be granted
only in unusual situations. Support from other sources is permissible during
the period of leave. Such leave does not reduce the total number of months
of program support for which an individual is eligible.
Under unusual and pressing circumstances, an awardee may submit a written
request to the awarding component, requesting a reduction in professional
effort below 75 percent. Such requests will be considered on a case-by-case
basis during the award period. In no case, will it be permissible to work at
a rate of less than 50 percent effort. The nature of the circumstances
requiring reduced effort might include medical conditions, disability, or
pressing personal or family situations such as child or elder care.
Permission to reduce the level of effort will not be approved to accommodate
other sources of funding, job opportunities, clinical practice, or clinical
training. In each situation, the grantee institution must submit
documentation supporting the need for reduced effort along with assurance of
a continuing commitment to the scientific development of the awardee.
Further, the awardee must submit assurance of his or her intention to return
to full-time professional effort (at least 75 percent) as soon as possible.
During the period of reduced effort, the salary and other costs supported by
the award will be reduced accordingly.
I. Termination or Change of Institution: When a grantee institution plans to
terminate an award, the NIH funding component must be notified in writing at
the earliest possible time so that appropriate instructions can be given for
termination. The Director of the NIH may discontinue an award upon
determination that the purpose or terms of the award are not being fulfilled.
In the event an award is terminated, the Director of the NIH shall notify the
grantee institution and career award recipient in writing of this
determination, the reasons therefor, the effective date, and the right to
appeal the decision.
Awardees planning a change of institution, must submit to the funding NIH
component in advance of the change a written request for transfer,
countersigned by the appropriate institutional business official, describing
the reasons for the change and including the new sponsor's name and
biosketch. The awardee must establish in this request that the specific aims
of the research program to be conducted at the new institution are within the
scope of the original peer reviewed research program. Additionally, the new
sponsor must have the appropriate research expertise to supervise the program
and sufficient research support to ensure continuation of the research
program to the end of the award (initial award). Staff within the NIH
funding component will review this request and may require a review by an
initial review group and/or the appropriate National Advisory Council or
Board. Upon approval of this request, a new career award application must be
submitted by the new institution far enough in advance of the requested
effective date to permit review. The period of support requested in the new
application must be no more than the time remaining within the existing award
period.
J. Change of Mentor: When a mentor at the grantee institution is to be
replaced, the institution must submit a letter from the proposed mentor
documenting the need for substitution, the new mentor's qualifications for
supervising the program, and the level of support for the candidate's career
development. The letter must also document that the specific aims of the
research program will remain within the scope of the original peer reviewed
research program. Staff within the NIH funding component will review the
request, and will notify the grantee institution of the results of the
evaluation.
A final progress report, invention statement, and Financial Status Report are
required upon either termination of an award or relinquishment of an award in
a change of institution situation.
INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of the NIH that women and members of minority groups and
their subpopulations must be included in all NIH supported biomedical and
behavioral research projects involving human subjects unless a clear and
compelling rationale and justification is provided that inclusion is
inappropriate with respect to the health of the subjects or the purpose of
the research. This policy results from the NIH Revitalization Act of 1993
(Section 492B of Public Law 103-43).
All investigators proposing research involving human subjects should read the
"NIH Guidelines For Inclusion of Women and Minorities as Subjects in Clinical
Research," which has been published in the Federal Register of March 20, 1994
(FR 59 14508-14513), and in the NIH Guide for Grants and Contracts, Volume
23, Number 11, March 18, 1994 available electronically at
http://grants.nih.gov/grants/guide/notice-files/not94-100.html.
Investigators may obtain copies from these sources or from the program staff
or contact person listed under INQUIRIES. Program staff may also provide
additional relevant information concerning the policy.
INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS
It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by
NIH, unless there are clear and compelling scientific and ethical reasons not
to include them. This policy applies to all initial (Type 1) applications
submitted for receipt dates after October 1, 1998.
All investigators proposing research involving human subjects should read the
"NIH Policy and Guidelines on the Inclusion of Children as Participants in
Research Involving Human Subjects" that was published in the NIH GUIDE FOR
GRANTS AND CONTRACTS, March 6, 1998 and is available at the following URL
address: http://grants.nih.gov/grants/guide/notice-files/not98-024.html.
APPLICATION PROCEDURES
Applications are to be submitted on the grant application form PHS 398 (rev.
4/98) and should use the instructions in Section IV of the application kit.
Applications will be accepted at the standard application deadlines as
indicated in the application kit. Application kits are available at most
institutional offices of sponsored research and from the Division of
Extramural Outreach and Information Resources, National Institutes of Health,
6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone
301/435-0714, Email: grantsinfo@nih.gov. The title and number of the PA must
be typed in Section 2 on the face page of the application form and the YES
box must be marked. Application kits are also available on the world wide
web at: http://grants.nih.gov/grants/funding/phs398/forms_toc.html.
All applications and proposals for NIH funding must be self-contained within
specified page limitations. Unless otherwise specified in an NIH
solicitation, internet addresses (URLs) should not be used to provide
information necessary to the review because reviewers are under no obligation
to view Internet sites. Reviewers are cautioned that their anonymity may be
compromised when they directly access an Internet site (see
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-004.html).
The completed original application and three legible copies must be sent or
delivered to:
CENTER FOR SCIENTIFIC REVIEW
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD 20892-7710
BETHESDA, MD 20817 (for express/courier service)
At the time of submission, two additional copies of the application must be
sent to:
Ms. Toby Friedberg
Division of Extramural Activities
National Cancer Institute
6116 Executive Boulevard, Room 8062
MSC 8329
Bethesda, MD 20892-8329
Rockville, MD 20852 (for express/courier service)
The application must address the following issues and include the following
information:
Candidate
o Describe the candidate's commitment to a career in basic biomedical
research directly relevant to human biology and cancer (candidates interested
in patient-oriented research should consider the Mentored, Patient-Oriented
Research Career Development Award (K23);
o Present evidence of the candidate's ability to interact and collaborate
with other scientists;
o Discuss prior training and how it relates to the objectives and plans of
the candidate;
o Discuss the innovativeness and quality of the candidate's research efforts
to this point in his/her research career;
o Letters of recommendation. Three sealed letters of recommendation
addressing the following issues:
- The adequacy of the candidate's scientific background for the proposed
research and career goals.
- The quality of the candidate's scientific productivity and achievements
(e.g. publications, intellectual contributions to the research environment)
- The candidate's ability to work with other scientists in various
interactive situations (e.g., seminars, journal clubs), on collaborative
research projects, and with support staff (e.g., technicians, nurses,
secretaries etc.)
- Evidence of the candidate's originality and innovativeness in pursuing a
research problem
- VERY IMPORTANTLY, the candidate's special potential to develop, establish
and manage an independent research program.
Career Development Plan
o Present a systematic plan that covers the mentored and unmentored phases
of this Program. This plan should incorporate the prior research training
and experience of the candidate to provide a basis for the need for further
career development to become an independent investigator focusing on cancer
research that is directly relevant to human biology and human disease. The
plan should provide a description of the research and training experiences
that will occur during the mentored and unmentored phases; and must present a
convincing case that, as a result of these experiences, the candidate will
have a high probability of developing the research skills and ability needed
to work in a collaborative environment and become a successful independently
supported investigator. The plan must include a statement regarding the
proposed length of the mentored and unmentored phases; the unmentored phase
must begin on the anniversary award date of the second, third or fourth year
of the grant.
o Document prior instruction in or propose plans for instruction in the
responsible conduct of research in terms of subject matter and duration of
instruction. (NO AWARD CAN BE MADE IF AN APPLICATION LACKS THIS COMPONENT).
Research Plan
o Describe the research plan using Form PHS 398 (rev. 4/98 or subsequent
revisions) following instructions for the Specific Aims, Background and
Significance, Progress Report/Preliminary Studies, Research Design and
Methods. The candidate should consult with the mentor regarding the
development of this section. The research plan must be directly relevant to
human biology and human cancer disease. It must be clear whether all or
parts of the Research Plan will go with the candidate when the transition to
an independent position is made or whether the candidate will be expected to
develop an entirely new project in the independent position.
Mentor's Statement
o The application must include a signed statement from the mentor(s)
including information on research qualifications and previous experience as a
research supervisor. The applications must also include information to
describe the mentor's research support related to the candidate's research
plan and nature of the supervision that will occur during the mentored phase
of the proposed award period;
o Similar information must be provided by any co-mentor. If more than one
mentor is proposed, the respective areas of expertise and responsibility
should be described.
o This statement should also specifically describe whether all or parts of
the research project being conducted by the candidate will go with the
candidate when the transition to an independent position is made or whether
the candidate will be expected to develop and entirely new project in the
independent position.
Environment and Institutional Commitment
o Describe the resources and facilities that will be available to the
candidate;
o Describe how the research environment of the institution is particularly
suited for the development of the candidate's research career and the pursuit
of the proposed research plan;
o In a clear statement, provide assurances that the candidate will be able
to spend a minimum of 75 percent effort in the development of his/her
research program, with the remaining percent effort spent on activities
related to the development of their research career.
Biographical Sketch
o Biographical Sketch
A biographical sketch is required for all key personnel. Provide information
on research projects completed and/or research grants participated in during
the last five years that are relevant to the proposed project.
Budget
Applicants using a PHS 398 Form bearing the revision date 4/98 must follow
the instructions in the form.
REVIEW CONSIDERATIONS
Applications will be reviewed for completeness by the Center for Scientific
Review and for adherence to the guidelines of this PA by the National Cancer
Institute. Incomplete applications will be returned to the applicant without
further consideration. Applications that are complete and responsive to the
PA will be evaluated for scientific and technical merit by an appropriate
scientific review group convened by the National Cancer Institute in
accordance with the standard NIH peer review procedures. As part of the
initial merit review, all applications will receive a written critique, and
may undergo a process in which only those applications deemed to have the
highest scientific merit, generally the top half of applications under
review, will be discussed, assigned a priority score, and receive a second
level review by the National Cancer Advisory Board.
The following review criteria will be applied:
Candidate
o Commitment of the candidate to a career in basic cancer research that will
be focused on problems directly relevant to human biology and human cancer
disease;
o Ability of the candidate to interact and collaborate with other
scientists;
o Quality of the prior scientific training and experience, including
publications that establish the innovativeness of the candidate in research
and a high potential for an independent research career;
o Recommendations of three well-established scientists attesting to the
special potential of the individual to pursue an independent career in cancer
research.
Career Development Plan
o Likelihood that the plan will contribute substantially to the scientific
development of the candidate, and the achievement of an independent research
program directly relevant to human biology and human cancer disease, based
on:
- Candidate's prior training and research experience;
- Appropriateness of the goals and scope of the plan to complement prior
training/research experience and achieve the stated training and research
objectives;
o Appropriateness of the proposed durations of the mentored and unmentored
phases;
o Appropriateness of the proposed activities during the mentored and
unmentored phases for a five year award;
o Adequacy of prior or proposed training in the responsible conduct of
research.
Research Plan
o Degree of relevance of the research plan to developing an independent
research program focused on human biology and human disease as they relate to
the etiology, pathogenesis, prevention, diagnosis, and/or treatment of human
cancer;
o A sound research project that is consistent with the development plan for
an independent career in cancer research and the candidate's level of
research development must be provided (All applicants for this award will
have had previous postdoctoral research experience and in some cases may have
been Principal Investigators on small research grants);
o Usefulness of the research plan as a vehicle for enhancing existing
research skills as described in the career development plan;
o The originality and quality of the research hypothesis/question, design
and methodology, judged in the context of the candidate's previous training
and experience.
o Attention to and implications of what aspects of Plan will go with the
candidate at the time of the transition to an independent position.
o Adequacy of the Plans attention to children, gender, and minority issues
when human subjects are involved.
Mentor/ Co-Mentor
o Appropriateness of the mentor's research qualifications in the area of the
proposed research;
o Quality and extent of the mentor(s)'s proposed role in providing guidance
and advice to the candidate.
o Previous experience in fostering the development of cancer researchers;
o History of research productivity and peer reviewed support;
o Adequacy of existing support for the mentored phase of the proposed
research project.
o Adequacy and clarity of the mentor(s)'s statement describing what aspects
of the Research Plan will go with the candidate when the transition is made
to an independent position.
Institutional Environment and Commitment
o Clear commitment of the institution to ensure that a minimum of 75 percent
of the candidate's effort will be devoted directly to research, with the
remaining percent effort being devoted to activities related to the
successful development of a research career;
o Adequacy of research facilities and training opportunities;
o Quality and relevance of the environment for scientific and professional
development of the candidate.
Budget
o Justification of the requested budget in relation to career development
goals and research aims and plans.
AWARD CRITERIA
The NCI will notify the applicant of the National Cancer Advisory Board's
(NCAB) action shortly after its meeting. Funding decisions will be made
based on the scientific merit of the application as evaluated by the initial
review group, the results of the secondary review by the NCAB, the need for
research personnel in specific program areas, and the availability of funds.
SUPPLEMENTAL GUIDELINES FOR TRANSITION TO THE UNMENTORED PHASE
These guidelines apply only to the non-competing year in which the transition
is requested. Other non-competing applications should be completed in
accordance with the guidelines for streamlined (SNAP) applications outlines
in PHS form 2590.
Application Procedure:
The application procedure for the initial Howard Temin Award cannot be used
for the transition to an unmentored status. Therefore, follow the
supplemental application guidelines below for this aspect of the Award:
When the candidate is remaining in the same institution, transition
applications are to be submitted on the Application for Continuation Grant
Form PHS 2590 (rev. 4/98 and subsequent revisions), including the additional
instructions for Research Career Award Applications starting on page IV-1.
When the candidate is changing institution, the application form to use is
the Form PHS 398, and it should be obtained from the grantee institution.
However, the NCI (see INQUIRIES) will provide a transfer application kit
,which includes the Form PHS 398, for this purpose. Transition applications
MUST be submitted for support two months prior to the anniversary date of the
second, third or fourth year of the award.
Submit a signed, typewritten original of the signed application and two
signed photocopies in one package to:
Records Management Center
Grants Administration
National Cancer Institute
Executive Plaza South, Suite T-42 MSC 7107
Bethesda, MD 20892-7107
Special instructions for completion of the application:
o To associate the application with a transition request, enter "NCI HOWARD
TEMIN AWARD (K01) TRANSITION" on Line 1, Form Page 1;
o Provide an itemized listing with associated projected costs for all items
on Form Page 2 (DETAILED BUDGET FOR NEXT BUDGET PERIOD). Also see
Instructions;
o Biographical Sketch (Form Page 4): Provide for all key personnel to be
involved in the research project. Provide information on research projects
completed and/or research grants participated in during the last five years
that are relevant to the proposed project.
o Progress Report Summary (Form Page 5): Follow guidelines in Instructions.
Additional instructions include:
- This section should be keep as short as possible. However, due to the
unique reporting requirements for the "transition" application, the section
may exceed two pages;
- Studies and Results (Item b): The information provided must clearly
justify a transition to the unmentored phase of the award;
- Plans (Item b): Follow the guidelines in the Instructions. Additional
information to be provided is as follows:
o Describe how the scope of the project initiated during the unmentored
phase will be changed in response to the increased level of research support
provided in the mentored phase of this award. Provide detailed research
plans if there is a major change in research scope of the original peer
reviewed research plan;
o Describe the DIRECT relevance of the research plan to the etiology,
pathogenesis, prevention, diagnosis, and/or treatment of human cancer;
o Describe how the proposed research and research-related activities should
contribute to the scientific development of the candidate, and the
development of an independently funded research program;
o Describe long term research career goals, including the timing of
submission of applications for investigator-initiated research grants;
o Provide a statement from the Chairperson of the department to which the
awardee has been recruited describing the type of faculty position offered
and if it is a tenure-track position (or equivalent); the responsibilities of
the position; the laboratory facilities that will be provided for exclusive
use by the awardee, and the relationship of these facilities to the
laboratories of
the applicant's mentor (if the transition does not involve a change of
sponsoring institution); additional non-PHS research related
departmental/institutional support that will be provided for technical
support staff, equipment, animals, etc; relationship of the awardee's
research program
to ongoing programs within the department; career plans for the awardee;
o Provide a statement from the institution ensuring that a minimum of 75
percent of the candidate's effort will be devoted directly to research, with
the remaining percent effort being devoted to activities related to the
successful development of a research career;
o If the transition involves a change of sponsoring institution, the new
institution must additionally document a strong, well-established program in
biomedical research related to cancer, including a high quality research
environment with staff capable of productive collaboration with the
candidate.
CANDIDATES PLANNING A CHANGE OF INSTITUTION MUST CONTACT NCI PROGRAM STAFF
PRIOR TO SUBMISSION OF THE TRANSITION APPLICATION.
o Provide a sealed statement from the mentor recommending the candidate for
the transition. This recommendation should be based on the scientific
productivity of the candidate under his/her mentorship, and on the mentor's
detailed evaluation that the candidate is ready to develop an innovative and
independently-supported research program. This letter should be mailed
directly to the NCI Program Director for the candidate's Howard Temin Award.
Review Considerations for a "Transition" Application:
Applications received will require NCI staff approval before the transition
award to an independent position is activated. Depending upon the scope of
changes in the research plan as compared with the original peer reviewed
grant application, the application could receive a second level of review by
an IRG. Approval will be based upon the following criteria:
o A statement from the mentor(s) verifying that the candidate is ready to
pursue an independent research career.
o The clear direct relevance of the new Research Plan to human biology and
human disease as they relate to cancer etiology, pathogenesis, prevention,
control, diagnosis and treatment;
o The soundness of the "Letter of Commitment" from the institution, to
provide the candidate with protected time (no less than 75 percent effort
dedicated to the development of a research program with the remaining effort
to be used in research related activities) and describing arrangements with
the candidate providing a permanent preferably tenure-track position,
adequate facilities for conducting a research program, and additional
resources conducive to the development of a research project and
establishment of a successful research career;
o The adequacy of the plans for inclusion of women, children, and minorities
in any clinical or population research activities, as applicable;
o The adequacy of the proposed protection of humans, animals or the
environment to the extent that they may be adversely affected by the
activities proposed in this application.
Award Criteria for a "Transition" Application:
Funding decisions will be made by NCI program staff based on satisfying the
review considerations above. NCI program staff will notify the applicant for
the transition to unmentored status of their action on the application. The
transition to the unmentored phase will take effect on the anniversary date
of the grant.
INQUIRIES
Inquiries are encouraged. The opportunity to clarify any issues or questions
from potential applicants is welcome. Depending upon whether your inquiry
involves application strategies and scientific issues, budget or fiscal
issues or review issues, contact the appropriate individual noted below:
Direct inquiries regarding programmatic issues to:
Dr. Andrew Vargosko
Office of Centers, Training and Resources
National Cancer Institute
6116 Executive Blvd., Suite 7011
MSC/8346
Bethesda, MD 20892-8346
Telephone: (301) 496-8580
FAX: (301) 402-4472
Email: av8b@nih.gov
Inquiries regarding fiscal matters may be directed to:
Ms. Catherine Blount
Office of Administrative Management
National Cancer Institute
Executive Plaza South, Room 243
Bethesda, MD 20892
Telephone: (301) 496-3179
FAX: (301) 496-8601
Email: cb136g@nih.gov
Direct inquiries regarding review matters to:
Ms. Toby Friedberg
Division of Extramural Activities
National Cancer Institute
6116 Executive Boulevard, Room 8062
MSC/8329
Bethesda, MD 20892-8329
Rockville, MD 20852 (for express/courier service)
Telephone: (301) 496-3428
FAX: (301) 402-0275
Email: tf12w@nih.gov
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance No.
93.398 Cancer Research Manpower. Awards are made under authorization of the
Public Health Service Act as amended by Sections 301 and 405 of the (42 USC
241 and 284) and administered under NIH grants policies and Federal
Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not
subject to the intergovernmental review requirements of
Executive Order 12372 or Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to provide a
smoke-free workplace and promote the non-use of all tobacco products. In
addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking
in certain facilities (or in some cases, any portion of a facility) in which
regular or routine education, library, day care, health care or early
childhood development services are provided to children. This is consistent
with the PHS mission to protect and advance the physical and mental health of
the American people.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
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