MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEARCH

Release Date:  April 6, 1998

PA NUMBER:  PA-98-053

P.T.

National Institute on Aging
National Institute on Alcohol Abuse and Alcoholism
National Institute of Allergy and Infectious Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Cancer Institute
National Center for Research Resources
National Institute of Child Health and Human Development
National Institute on Deafness and Other Communication Disorders
National Institute on Dental Research
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Drug Abuse
National Institute of Environmental Health Sciences
National Institute of Nursing Research
National Eye Institute
National Heart, Lung, and Blood Institute
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
Office of Alternative Medicine

Application Receipt Dates:  February 1, June 1, and October 1

THIS PA USES THE "JUST IN TIME" CONCEPT(as described in the NIH GUIDE FOR GRANTS
AND CONTRACTS, Volume 25, Number 10, March 29, 1996, and Volume 25, Number 16,
May 17, 1996).  IT INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION
INSTRUCTIONS THAT MUST BE USED WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS
PA.

PURPOSE

The purpose of the Midcareer Investigator Award in Patient-Oriented Research
(K24) is to provide support for clinicians to allow them protected time to devote
to patient-oriented research and to act as mentors for beginning clinical
investigators.  The target candidates are outstanding clinical scientists engaged
in patient-oriented research who are within 15 years of their specialty training,
who can demonstrate the need for a period of intensive research focus as a means
of enhancing their clinical research careers, and who are committed to mentoring
the next generation of clinical investigators focussing on patient-oriented
research.  The award is intended to further the research and mentoring endeavors
of outstanding patient-oriented investigators, enable them to expand their
potential to make significant contributions to their field of patient-oriented
research, and to act as mentors for beginning clinicians.

For the purposes of this award, patient-oriented research is defined as research
conducted with human subjects (or on material of human origin such as tissues,
specimens, and cognitive phenomena) for which an investigator directly interacts
with human subjects.  This area of research includes: 1) mechanisms of human
disease; 2) therapeutic interventions; 3) clinical trials, and; 4) the
development of new technologies.

The NIH is especially interested in increasing the number of scientists trained
to conduct high-quality clinical research.  Accordingly, this award forms an
important part of the NIH initiative to attract and retain talented individuals
to the challenges of patient-oriented research. With a view towards stabilizing
clinical research settings and preventing an interruption in trainee mentoring,
the NIH has chosen to establish the MIDCAREER INVESTIGATOR AWARD IN PATIENT-
ORIENTED RESEARCH.  This award is intended to relieve clinical investigators from
patient care duties and administrative responsibilities, thereby increasing the
opportunities for clinicians in midcareer to be well grounded in patient-oriented
research.  This initiative is consistent with the recommendations of the NIH
Director's Panel on Clinical Research (http://www.nih.gov/news/crp/index.html)
and the recommendations from the Institute of Medicine Committee on Addressing
Career Paths for Clinical Research.

The objectives of the Midcareer Investigator Award in Patient-Oriented Research
(K24) are to:

-  encourage midcareer clinicians to devote more time to patient-oriented
research and enhance their clinical research skills in order to conduct
meritorious patient-oriented research and mentor beginning clinical
investigators.

-  increase the pool of clinical researchers who can conduct patient-oriented
studies, capitalizing on the discoveries of biomedical research and translating
them to clinical settings.

This Award will enable candidates holding clinical degrees (see ELIGIBILITY
REQUIREMENTS below) to undertake up to five years(a minimum of three years is
required) of patient-oriented research, thereby further developing their research
skills, devoting time to patient-oriented research, and acting as a mentor and
role model for beginning clinical researchers.

The prospective candidate for the Midcareer Investigator Award in Patient-
Oriented Research should propose a period of patient-oriented research consistent
with his/her research and clinical experience and further development of research
skills.  All programs should be carefully tailored to meet the individual needs
of the candidate and must include a description of a research project that meets
the definition of patient-oriented research.  In addition, the candidate should
have a demonstrated record of conducting meritorious patient-oriented research
and have experience in mentoring (or  demonstrate mentoring capabilities) and
describe mentoring activities that will involve beginning clinicians with little
or no research experience.  The applicant must have independent research support
at the time of application for this program.  This award is intended to enable
the candidate to devote a greater percent effort to patient-oriented research.

HEALTHY PEOPLE 2000

The Public Health Service is committed to achieving the health promotion and
disease prevention objectives of "Healthy People 2000," a PHS-led national
activity for setting priority areas. This program Announcement, Midcareer
Investigator Award in Patient-Oriented Research, is related to the priority area
of human resource development. Potential candidates may obtain a copy of "Healthy
People 2000" (Full Report: Stock No. 017-001-00474-0 or Summary Report: Stock No.
017-001-00473-1) from the Superintendent of Documents, Government Printing
Office, Washington, DC 20402-9325 (telephone 202/512-1800) or electronically
(http://odphp.osophs.dhhs.gov/pubs/hp2000).

ELIGIBILITY REQUIREMENTS

Candidates for this award must have a clinical degree or its equivalent,
including the M.D., D.O., D.D.S., D.M.D., O.D., D.C., N.D. (Doctor of
Naturopathy), and doctorally prepared nurses.  In addition, individuals holding
the Ph.D. degree may apply for the award if they have been certified to perform
clinical duties, such as a clinical psychologist, clinical geneticist, etc. 
Candidates must have completed their specialty training within 15 years of
submitting the application, and there is no age limit for candidates. In
exceptional circumstances, the period of eligibility may be extended if it can
be demonstrated that candidates had an interruption in their career progression
due to family or personal circumstances.

Candidates must be working in a research environment, conducting patient-oriented
research, and have independent  research support.  Candidates must be willing to
spend  up to 50 percent effort(at least 25%) conducting patient-oriented 
research and mentoring. All programs should be carefully tailored to meet
individual needs and capabilities of candidates.

Applications may be submitted on behalf of candidates by domestic, non-Federal
organizations, public or private, such as medical, dental, or nursing schools or
other institutions of higher education.  Minorities, women and individuals with
disabilities are encouraged to apply.  At the time of award, candidates must be
citizens or noncitizen nationals of the United States, or must have been lawfully
admitted to the United States for permanent residence (i.e., in possession of a
currently valid Alien Registration Receipt Card I- 551, or other legal
verification of such status).  Noncitizen nationals are generally persons born
in outlying possessions of the United States (i.e., American Samoa and Swains
Island).  Individuals on temporary visas are not eligible.

A candidate for the MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEARCH may
not concurrently apply for any other PHS award that duplicates the provisions of
this award. Recipients of this award are required to hold independent research
support, either Federal or private, during the period of this award.  However,
they may not receive additional compensation on another federal award that
exceeds the maximum allowable salary
compensation (currently $125,000 per year.)

MECHANISM OF SUPPORT

Awards in response to this program announcement will use the K24 mechanism.
Planning, direction, and, execution of the program will be the responsibility of
the candidate on behalf of the applicant institution. The project period may be
for up to five years(at least three years are required) . Awards are renewable
for one additional five year period if the candidate still meets the stated
requirements. Specific K24 application instructions have been modified to reflect
"JUST IN TIME" streamlining efforts being examined by the NIH. "Just IN TIME"
postpones the
collection of certain information that currently must be included in all
competing applications when submitted. The "JUST IN TIME" concept allows
applicants to submit certain information only when there is a possibility for an
award. It is anticipated that these changes will reduce the administrative burden
for the applicants, applicant institutions, reviewers, and NIH staff.

AWARDS AVAILABLE

The overall goal of the NIH is to support between 60 and 80 awards in Fiscal Year
1999 and in each succeeding year through Fiscal Year 2003. The actual number of
awards to be made by each Institute or Center will vary yearly and will be
dependent upon the number and quality of applications submitted and funds
available.

RESEARCH OBJECTIVES

A.  Environment:  The institution must have a well-established research and
clinical career development program.  The institution must be able to demonstrate
a commitment to the candidate as a productive, independent investigator.  The
candidate and institution must be able to describe a career program that will
utilize the relevant research and educational resources and the institution must
certify that the candidate will be released from other duties and be able to
devote up to 50 percent effort(at least 25 percent effort) to a patient-oriented 
research program. The Institution must demonstrate the availability of beginning
clinical investigators to be mentored.

B.  Program:  The award provides up to five consecutive 12-month awards. Up to
50 percent of the investigator's effort(at least 25 percent) must be devoted to
the patient-oriented research program and mentoring.  The remainder may be
devoted to other clinical, teaching, or research pursuits consonant with the
objectives of the award. The research phase of an award period must be devoted
to patient-oriented research in scientific areas relevant to the career goals of
the candidate.

C.  Allowable Costs:

1.  Salary:  The NIH will provide salary for the award recipient of up to $62,500
per year plus commensurate fringe benefits for up to 50 percent effort.  At least
25 percent effort is required.  The institution may supplement the NIH
contribution up to a level that is consistent with the institution's salary
scale.  Institutional supplementation of salary must not require extra duties or
responsibilities that would interfere with the purpose of the award.

Recipients of this award may derive additional compensation from other Federal
sources or awards provided the total salary derived from all Federal sources does
not exceed $125,000 per year and their total percent effort does not exceed 100
percent.  Direct salary is exclusive of fringe benefits and facilities and
administrative costs.

The total salary requested must be based on a full-time, 12-month staff
appointment.  It must be consistent both with the established salary structure
at the institution and with salaries actually provided by the institution from
its own funds to other staff members of equivalent qualifications, rank, and
responsibilities in the department concerned.  If full-time, 12-month salaries
are not currently paid to comparable staff members, the salary proposed must be
appropriately related to the existing salary structure.

2.  Research Development Support:  The NIH will provide generally up to $25,000
per year for the following expenses:  (a) research expenses, such as supplies,
equipment and technical personnel for the principal investigator and his/her
mentored clinical investigators; (b) travel to research meetings or training; (c)
statistical services including personnel and computer time.

3.  Ancillary Personnel Support:  Salary for secretarial, and administrative
assistance etc., is not allowed.

4.  Facilities and Administrative costs:  These costs will be reimbursed at 8
percent of modified total direct costs.

D.  Evaluation:  In carrying out its stewardship of human resource related
programs, the NIH may request information essential to an assessment of the
effectiveness of this program. Accordingly, recipients are hereby notified that
they may be contacted after the completion of this award for periodic updates on
various aspects of their employment history, publications, support from research
grants or contracts, honors and awards, professional activities, and other
information helpful in evaluating the impact of the program.

E.  Special Leave:  Leave to another institution, including a foreign laboratory,
may be permitted if directly related to the purpose of the award.  Only local,
institutional approval is required if such leave does not exceed 3 months.  For
longer periods, prior written approval of the NIH funding component is required.
To obtain prior approval, the award recipient must submit a letter to the NIH
describing the plan, countersigned by his or her department head and the
appropriate institutional official.  A copy of a letter or other evidence from
the institution where the leave is to be taken must be submitted to assure that
satisfactory arrangements have been made.  Support from the career award will
continue during such leave.

Leave without award support may not exceed 12 months.  Such leave requires the
prior written approval of the NIH funding component and will be granted only in
unusual situations.  Support from other sources is permissible during the period
of leave.  Such leave does not reduce the total number of months of program
support for which an individual is eligible.  Parental leave will be granted
consistent with the policies of the NIH and the grantee institution.

F.  Termination or Change of Institution:  When a grantee institution plans to
terminate an award, the NIH funding component must be notified in writing at the
earliest possible time so that appropriate instructions can be given for
termination. If the individual is moving to another eligible institution, career
award support may be continued provided:

A new career award application is submitted by the new institution;

All conditions of the award are met at the new institution;

The period of support requested is no more than the time remaining within the
existing award period; and

The new application is submitted far enough in advance of the requested effective
date to allow the necessary time for review.

The funding component may require a review by an initial review group and/or the
appropriate National Advisory Council or Board.  Alteratively, review may be
carried out by staff within the NIH funding component depending upon the
circumstances.

The NIH may discontinue an award upon determination that the purpose or terms of
the award are not being fulfilled.  In the event an award is terminated, the
Director of the NIH shall notify the grantee institution and career award
recipient in writing of this determination, the reasons therefor, the
effective date, and the right to appeal the decision.

A final progress report, invention statement, and Financial Status Report are
required upon either termination of an award or relinquishment of an award in a
change of institution situation.

INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS

For research projects involving human subjects, it is the policy of the NIH that
women and members of minority groups and their subpopulations must be included
in all NIH supported biomedical and behavioral research projects involving human
subjects unless a clear and compelling rationale and justification is provided
that inclusion is inappropriate with respect to the health of the subjects or the
purpose of the research.  This policy results from the NIH Revitalization Act of
1993 (Section 492B of Public Law 103-43).  All investigators proposing research
involving human subjects should read the "NIH Guidelines For Inclusion of Women
and Minorities as Subjects in Clinical Research," which has been published in the
Federal Register of March 28,1994 (FR 59 14508-14513), and in the NIH GUIDE FOR
GRANTS AND CONTRACTS of March 18,1994, Volume 23, Number 11. It is also available
electronically at http://www.nih.gov/grants/guide/notice-files/not94-100.html

Investigators may obtain copies from these sources or from the program staff or
contact person listed below. Program staff may also provide additional relevant
information concerning the policy.

NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS

It is the policy of NIH that children (i.e., individuals under the age of 21)
must be included in all human subjects research, conducted or supported by NIH,
unless there are scientific and ethical reasons not to include them. This policy
applies to all applications submitted in response to this Program Announcement.
All investigators proposing research involving human subjects should read the
"NIH POLICY AND GUIDELINES ON THE INCLUSION OF CHILDREN AS PARTICIPANTS IN
RESEARCH INVOLVING HUMAN SUBJECTS" that was published in the NIH GUIDE FOR GRANTS
AND CONTRACTS, March 6, 1998 and is available at the following URL address:
http://www.nih.gov/grants/guide/notice-files/not98-024.html

As part of the scientific and technical merit evaluation of the research plan,
reviewers will be instructed to address "the adequacy of plans for including
children as appropriate for the scientific goals of the research, or
justification for exclusion.

APPLICATION PROCEDURES

This is an NIH-wide program announcement for the Midcareer Investigator Award in
Patient-Oriented Research.  Therefore, all candidates are strongly encouraged to
contact the staff person in the relevant institute or center listed under
INQUIRIES.  Such contact should occur early in the planning phase of application
preparation.  Such contact will help ensure that applications are responsive to
the goals and policies of the individual institute or center.

Applicants who will be using a General Clinical Research Center (GCRC) are
requested to include a letter from either the GCRC program director or the
principal investigator with the application.

Applications are to be submitted on the grant application form PHS 398 (rev.
5/95-use the instructions in Section IV as appropriate) and will be accepted on
or before the receipt dates indicated in the application kit.  Forms are
available at most institutional offices of sponsored research and from the
Division of Extramural Outreach and Information Resources, National Institutes
of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, Phone (301)
710-0267, FAX: (301) 480-0525, Email: asknih@od.nih.gov.  Forms are also
available on the NIH Website at
http://www.nih.gov/grants/funding/phs398/phs398.html

To identify the application as a response to this program announcement, check
"YES" on item 2 of page 1 of the application and enter "PA-98-053, Midcareer
Investigator Award in Patient-Oriented Research."

Submit a signed, typewritten original of the application with five signed
photocopies, in one package to:

CENTER FOR SCIENTIFIC REVIEW (FORMERLY DIVISION OF RESEARCH GRANTS)
NATIONAL INSTITUTES OF HEALTH
6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC 7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817-7710 (for express/courier service)

The application must contain the following:

Candidate

o  A description of the candidate's commitment to a career in patient-oriented
research.

o  Evidence of the candidate's ability to conduct high quality patient-oriented
research.

o  A description of immediate and long-term career objectives, explaining how the
award will contribute to their attainment.

o  A description of how the award will contribute to a patient-oriented research
program and how it will relieve the candidate from other patient care or
administrative duties.

Research Plan

o  A commitment of up to 50 percent effort(at least 25 percent effort) to the
patient-oriented research program.

o  A description of the ongoing patient-oriented research.  The research plan
should briefly describe the specific aims, the background and significance of the
studies, and the research design and methods.  Additional research may be
proposed as a basis for this award.

o  Documentation that appropriate and adequate resources, both in terms of
support and facilities, are available to the candidate to conduct the research
program.  This must include a description of other monetary support that will be
utilized to conduct the research program.

Mentoring Plan

o  A demonstrated record of mentoring or training clinical investigators or a
demonstration of the capability to provide mentoring to beginning clinical
investigators.

o  A description of plans for providing mentoring opportunities to beginning
clinical investigators, including a description of the type of clinical
investigators that could be mentored, plans for recruiting and selecting such
individuals, and the type of training and educational experiences to be provided.

Environment and Institutional Commitment

o  The sponsoring institution must document a strong, well-established patient-
oriented research and training program related to the candidate's area of
interest including a high-quality research environment with staff capable of
productive collaboration with the candidate.  The sponsoring institution also
must provide a statement of commitment to enhancing the candidate's ability as 
a productive, independent investigator.

o  The sponsoring institution must provide documentation that the candidate will
be relieved from other duties, patient care, administrative, etc., to allow
him/her to devote time to the patient-oriented research program.

Budget Instructions

The total direct costs must be requested in accordance with the K24 program
guidelines, following the budget instructions
described below.

o  Face Page-As a reminder, Item 7 should be completed to indicate direct costs
requested and Item 8 should reflect total costs(direct plus Facilities and
Administrative)

o  Detailed Budget for Initial Budget Period - Do not complete form page 4 of the
PHS 398 (rev. 5/95).  It is not required nor will it be accepted at the time of
application.  In some cases it may be requested prior to award.

o  Budget for Entire Proposed Period of Support - Do not complete the categorical
budget table on form page 5 in the PHS 398 (rev. 5/95).  Only the requested total
direct costs for each year and total direct costs for the entire proposed period
of support should be shown.

o  Begin the budget justification in the space provided, using continuation pages
as needed.

o  List the name, role on project and percent effort for all project personnel
(salaried or unsalaried) and provide a narrative justification for each person
based on his/her role on the project and proposed level of effort.

o  Identify all consultants by name and organizational affiliation and describe
the services to be performed.

o  Provide a narrative justification for any major budget items, other than
personnel, that are requested for the conduct of the project that would be
considered unusual for the scope of research. No specific costs for items or
categories should be shown.

o  Facilities and Administrative costs will be calculated at the time of the
award using the 8% rate.  Applicants will be asked to identify the exclusions
prior to award.

o  If consortium/contractual costs are requested, provide the percentage of the
subcontract total costs (direct plus Facilities and Administrative) relative to
the total direct costs of the overall project.  The subcontract budget
justification should be prepared following the instructions provided above.

Biographical Sketch

A biographical sketch is required for all key personnel, following the modified
instructions below.  Do not exceed the two-page limit for each person.

o  Complete the education block at the top of the form page.

o  List current position(s) and those previous positions directly relevant to the
application.

o  List selected peer-reviewed publications directly relevant to the proposed
project, with full citation.

o  Provide information on research projects completed and/or research grants
participated in during the last five years that are relevant to the proposed
project.  Title, principal investigator, funding source, and role on project must
be provided.

Other Support

Do not complete the other support page (format page 7 of the PHS 398 (rev.
5/95)).  Information on active support for key personnel will be requested prior
to award.  A completed checklist will be required prior to award.

REVIEW CONSIDERATIONS

Applications will be reviewed for completeness by the Center for Scientific
Review and for responsiveness to this program announcement by the appropriate
institute or center staff.  Incomplete or non-responsive applications will be
returned to the applicant without further consideration. Applications that are
complete and responsive to the program announcement will be evaluated for
scientific and technical merit by a peer review group convened by the appropriate
Institute or Center in accordance with the standard NIH peer review procedures.
As part of the initial merit review, all applications will receive a written
critique and undergo a process in which only those applications deemed to have
the highest scientific merit, generally the top half of applications under
review, will be discussed, assigned a priority score, and receive a second level
review by the appropriate national advisory council or board.

The following review criteria will be applied:

Candidate

o  Quality of the candidate's academic and clinical record, including
capabilities and commitment to serve as a mentor;

o  Evidence of ongoing high quality patient-oriented research and the
relationship of that research to this program;

o  Potential to conduct quality patient-oriented research;

o  Commitment to a patient-oriented research career;

o  Appropriateness of the content and duration of the proposed research program;

o  Evidence of monetary support for patient-oriented research.

Research Plan

Although it is understood that K24 applications do not require the level of
detail necessary in regular research grant applications, a fundamentally sound
research plan must be provided.  In general, less detail is expected with regard
to research planned for the later years of the award, but the application should
outline the general goals for these years.

o  Appropriateness of the research plan as a vehicle for demonstrating skills and
capabilities in patient-oriented research.

o  Scientific and technical merit of the proposed research.

o  Relevance of the proposed research to the candidate's career objectives;

o  Availability of adequate resources to conduct the research program;

o  Demonstration that the proposed program will relieve the candidate from other
patient care or administrative duties and allow him/her to devote time to
patient-oriented research; and

o  Adequacy of the plan's attention to gender and minority issues associated with
projects involving human subjects.

o  Adequacy of plans for including children as appropriate for the scientific
goals of the research, or justification for exclusion.

Mentoring Plan

o  Experience and potential to serve as a mentor.

o  Adequacy of the plans for mentoring or supervising beginning clinicians in
patient-oriented research.

Environment and Institutional Commitment

o  Applicant institution's commitment to the scientific development of the
candidate and assurances that the institution intends the candidate to be an
integral part of its research program;

o  Adequacy of research facilities and the availability of appropriate
educational opportunities;

o  Quality and relevance of the environment for scientific and professional
development of the candidate and others pursuing patient-oriented research;and

o  Applicant institution's commitment to provide adequate time for conduct of the
research program.

AWARD CRITERIA

The institute or center will notify the applicant of the board or council's
action shortly after its meeting.  Funding decisions will be made based on the
recommendations of the initial review group and council/board, the need for
research personnel in specific program areas, and the availability of funds.  The
NIH policy on submission of revised (amended) applications limits the number of
such applications to two.

INQUIRIES

Written and telephone inquiries concerning this program announcement are strongly
encouraged especially during the planning phase of the application.  Below is a
listing of each institute's or center's program contact.

Direct inquiries regarding programmatic issues to:

Mary D. Leveck, Ph.D., R.N.
Scientific Program Administrator
National Institute of Nursing Research
Building 45, Room 3AN-12
Bethesda, MD  20892-6300
Telephone:  (301) 594-5963
FAX:  (301) 480-8260
Email:  mary_leveck@nih.gov

James A. Lipton, DDS, Ph.D.
National Institute of Dental Research
Natcher Building, Room 4AN-18J
Bethesda, MD  20892-6402
Telephone:  (301) 594-2618 or 594-7710
FAX:  (301) 480-8318
Email:  liptonj@de45.nidr.nih.gov

Maria Y. Giovanni, Ph.D.
Research Training Officer
National Eye Institute
6120 Executive Boulevard, Suite 350
Bethesda, MD  20892-7164
Telephone:  (301) 496-0484
FAX:  (301) 480-3246
Email:  myg@nei.nih.gov

Andrea Baruchin, Ph.D.
Office of Science Policy and Communication
National Institute on Drug Abuse
Parklawn Building, Room 10A 55
Rockville, MD  20857
Telephone:  (301) 443-6071
FAX:  (301) 443-6277
Email:  abaruchi@ngmsmtp.nida.nih.gov

Richard Fuller, M.D.
Division of Clinical and Prevention Research
National Institute on Alcohol Abuse and Alcoholism
6000 Executive Boulevard
Bethesda, MD  20892-7003
Telephone:  (301) 443-1206
FAX:  (301) 443-8774
Email:  rfuller@willco.niaaa.nih.gov

Daniel A. Sklare, Ph.D.
Division of Human Communication
National Institute on Deafness and Other Communication Disorders
6120 Executive Boulevard, Room 400C
Bethesda, MD  20892-7180
Rockville, MD  20852 (for express/courier service)
Telephone:  (301) 496-1804
FAX:  (301) 402-6251
Email:  daniel_sklare@nih.gov

Inese Beitins, M.D.
Clinical Research Area
National Center for Research Resources
6705 Rockledge Drive, Room 6120
Bethesda, MD  20892-7965
Telephone:  (301) 435-0790
FAX:  (301) 480-3661
Email:  ineseb@ep.ncrr.nih.gov

Joseph S. Drage, M.D.
Training and Special Programs Officer
National Institute of Neurological Disorders and Stroke
7550 Wisconsin Avenue, Room 1016
Bethesda, MD  20892
Telephone:  (301) 496-4188
FAX:  (301) 402-0219
Email:  jd66x@nih.gov

Milton J. Hernandez, Ph.D.
Office of Research on Minority and Women's Health
National Institute of Allergy and Infectious Diseases
Solar Building, Room 3C21
Bethesda, MD  20892-7630
Telephone:  (301) 496-3775
FAX:  (301) 402-0369
Email:  mh35c@nih.gov

Michael J. Galvin, Ph.D.
Division of Extramural Research and Training
National Institute of Environmental Health Sciences
P.O. Box 12233, EC-23
Research Triangle Park, NC  27709
Telephone:  (919) 541-7825
FAX:  (919) 541-5064
Email:  galvin@niehs.nih.gov

Thomas P. Blaszkowski, Ph.D.
Division of Epidemiology and Clinical Applications
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 8106
Bethesda, MD  20892-7938
Telephone:  (301) 435-0417
FAX:  (301) 480-1864
Email:  blaszkot@gwgate.nhlbi.nih.gov

Joyce Creamer, M.B.A.
Division of Blood Diseases and Resources
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Suite 10170
Bethesda, MD  20892-7590
Telephone:  (301) 435-0064
FAX:  (301) 489-0867
Email:  creamerj@gwgate.nhlbi.nih.gov

Bette A. Houston
Division of Blood Diseases and Resources
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 10154
Bethesda, MD  20892-7950
Telephone:  (301) 435-0061
FAX:  (301) 480-0868
Email:  houstonb@gwgate.nhlbi.nih.gov

Mary S. Reilly, M.S.
Division of Lung Diseases
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 10112
Bethesda, MD  20892-7952
Telephone:  (301) 435-0222
FAX:  (301) 480-3557
Email:  mr50w@nih.gov

Beth Schucker, M.A.
Division of Heart and Vascular Diseases
National Heart, Lung and Blood Institute
6701 Rockledge Drive, Room 9206
Bethesda, MD  20892-7940
Telephone:  (301) 435-0535
FAX:  (301) 480-1454
Email:  schuckeb@gwgate.nhlbi.nih.gov

Lester S. Gorelic, Ph.D.
Cancer Training Branch
National Cancer Institute
6130 Executive Boulevard, Room 520
Bethesda, MD  20892-7390
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email:  gorelicl@dcbdcep1.nci.nih.gov

Andrew Vargosko, Ph.D.
Cancer Training Branch
National Cancer Institute
6130 Executive Boulevard, Room 520
Bethesda, MD  20892-7390
Telephone:  (301) 496-8580
FAX:  (301) 402-4472
Email:  vargoska@dcbdcep1.nci.nih.gov

Richard L. Nahin, M.P.H., Ph.D.
Office of Alternative Medicine
National Institutes of Health
Building 31, Room 5B-38
Bethesda, MD  20892-2182
Telephone:  (301) 496-4792
FAX:  (301) 480-3519
Email:  nahinr@od31em1.od.nih.gov

Robin A. Barr, Ph.D.
Office of Extramural Affairs
National Institute on Aging
7201 Wisconsin Avenue, Room 2C218
Bethesda, MD  20892-9205
Telephone:  (301) 496-9322
FAX:  (301) 402-2945
Email:  rb42h@nih.gov

Richard W. Lymn, Ph.D.
Research Training Officer
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Building 45, Room 5AS-49E
Bethesda, MD  20892-6500
Telephone:  (301) 594-5128
FAX:  (301) 480-4543
Email:  richard_w_lymn@nih.gov

Ronald N. Margolis, Ph.D.
Division of Diabetes, Endocrinology and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 5AN12J
Bethesda, MD  20892-6600
Telephone:  (301) 594-8819
FAX:  (301) 480-3503
Email:  margolisr@extra.niddk.nih.gov

Judith M. Podskalny, Ph.D.
Division of Digestive Diseases and Nutrition
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AN12E
Bethesda, MD  20892-6600
Telephone:  (301) 594-8876
FAX:  (301) 480-8300
Email:  podskalnyj@extra.niddk.nih.gov

Charles H. Rodgers, Ph.D.
Division of Kidney, Urologic and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Natcher Building, Room 6AS19J
Bethesda, MD  20892-6600
Telephone:  (301) 594-7726
FAX:  (301) 480-3510
Email:  rodgersc@extra.niddk.nih.gov

Walter L. Goldschmidts, Ph.D.
Division of Basic & Clinical Neuroscience Research
National Institute of Mental Health
Parklawn Building, Room 11-1103
Rockville, MD  20857
Telephone:  (301) 443-3563
FAX:  (301) 443-1731
Email:  wg8u@nig.gov

Leonard Mitnick, Ph.D.
Division of Mental Disorders, Behavioral Research & AIDS
National Institute of Mental Health
Parklawn Building, Room 18-105
Rockville, MD  20857
Telephone:  (301) 443-6100
FAX:  (301) 443-1731
Email:  lm32p@nih.gov

Kenneth G. Luttermen, Ph.D.
Division of Services & Intervention Research
National Institute of Mental Health
Parklawn Building, Room 10C-23
Rockville, MD  20857
Telephone:  (301) 443-3373
FAX:  (301) 443-4045
Email:  kl21o@nih.gov

Steven L. Klein, Ph.D.
Developmental Biology, Genetics and Teratology Branch
National Institute of Child Health and Human Development
Building 61E, Room 4B01F
Bethesda, MD  20892-7510
Telephone:  (301) 496-5541
FAX:  (301) 402-4083
Email:  sk56d@nih.gov

AUTHORITY AND REGULATIONS

This program is described in the Catalog of Federal Domestic Assistance Nos. 93.
855 and 93.856.  Awards are made under the authority of title III, Section 301
of the PHS Act as amended.  The Code of Federal Regulations, Title 42 Part 52 and
Title 45 Part 74, are applicable to this program.  This program is not subject
to the intergovernmental review requirements of Executive Order 12372 to Health
Systems Agency review.

The PHS strongly encourages all grant and contract recipients to provide a smoke-
free workplace and promote the non-use of all tobacco products.  In addition,
Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain
facilities (or in some cases, any portion of a facility) in which regular or
routine education, library, day care, health care or early childhood development
services are provided to children.  This is consistent with the PHS mission to
protect and advance the physical and mental health of the American people.

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	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)