NIH GUIDE, Volume 21, Number 21, June 5, 1992

PA NUMBER:  PA-92-85

P.T. 44


  Biomedical Research Training 

  Cardiovascular Diseases 

  Blood Diseases 

  Pulmonary Diseases 

National Heart, Lung, and Blood Institute

Letter of Intent Receipt Date:  July 1, 1992

Application Receipt Date:  August 24, 1992


The National Heart, Lung, and Blood Institute (NHLBI) announces a

program directed at developing the research capabilities of faculty

investigators at minority schools in areas relevant to cardiovascular,

pulmonary, and hematologic diseases and resources.  The purpose of the

award is to encourage the enhancement of research skills in the areas

of interest to the NHLBI by faculty members at minority institutions

and to increase the number of minority individuals involved in research



The Public Health Service (PHS) is committed to achieving the health

promotion and disease prevention objectives of "Healthy People 2000,"

a PHS-led national activity for setting priority areas.  This program

announcement, Minority School Faculty Development Award, is related to

the priority area of heart disease and stroke.  Potential applicants

may obtain a copy of "Healthy People 2000" (Full Report:  Stock No.

017-001-00474-0) or "Healthy People 2000" (Summary Report:  Stock No.

017-001-00473-1) through the Superintendent of Documents, Government

Printing Office, Washington, DC 20402-9325 (telephone 202-783-3238).


Grants in this program will be made to domestic minority institutions

on behalf of awardees, each of whom will work with a mentor at a nearby

(within 100 miles) research center, who is recognized as an

accomplished investigator in the research area proposed, and who will

provide guidance for the awardee's development and research plan.  A

minority school is defined as a domestic medical or non-medical

college, university or equivalent school in which students of minority

ethnic groups, including Blacks, Hispanics, American Indians, and Asian

and Pacific Islanders, comprise a majority or significant proportion of

the school enrollment.

Candidates for this award are minority school faculty members who (1)

are citizens of the United States, non-citizen nationals or permanent

residents at the time of application, (2) have a doctoral degree or

equivalent in a biomedical or behavioral science, (3) wish to receive

specialized training in cardiovascular, pulmonary, or hematologic

research, and (4) have the background and potential to benefit from the

training.  Each candidate must identify and complete arrangements with

a nearby mentor (within approximately 100 miles), who is recognized as

an accomplished investigator in the research area proposed, and who

will provide guidance for the awardee's development and research plan.

Plans for the intensive training during the summer period (two to three

months) as well as during the academic years must be developed with the



The mechanism of support is the Minority School Faculty Developmental

Award (K14).  Awards will be made to the minority institution on behalf

of the awardee.  Each award will have a duration of five years and is

non-renewable.  These awards may not be transferred to another

institution or another faculty member.  Funding beyond the first year

of the grant is contingent upon satisfactory progress during the

preceding year.  If funds are to be transferred to the mentor's

institution for any purpose, arrangements for the transfer or conduct

of activities must be formalized in a contract or written agreement

with the mentor's institution.

The awardee may receive salary support up to a maximum of $50,000 plus

fringe benefits per year for five years.  All funds must be used to

support the awardee.  Awardees must commit 100 percent of effort during

summer and/or off quarter periods and at least 25 percent of effort

during the academic year.  In addition to the salary request for the

candidate, support for up to 10 percent of the mentor's salary during

the summer experience may also be requested.  Up to $20,000 per year

will be provided for research support.  Details regarding the

apportionment of these funds between the minority institution and the

research center must be worked out with the mentor at the research

center and agreed to by representatives of both institutions.  Indirect

costs will be awarded on eight percent of the total direct costs

exclusive of equipment.  The indirect cost rate on subcontract costs

for the mentor's institution may not exceed eight percent of total



The Minority School Faculty Development Award is intended to:

o  Encourage the development of faculty investigators at minority

schools in areas relevant to cardiovascular, pulmonary, and

hematologic* diseases and transfusion medicine.

o  Stimulate cardiovascular, pulmonary, and hematologic disease

research, prevention, control, and education by offering minority

school faculty members the opportunity to enhance their research

capabilities in these areas.

* Within the NHLBI, the term "hematologic" covers research on

thrombosis and hemostasis, immunohematology, blood cell disorders,

hematopoiesis, thalassemia, sickle cell disease, transfusion medicine

including blood component and derivative therapy, blood substitutes and

blood resource management, aspects of AIDS-products in AIDS prevention

and treatment, and AIDS-related bone marrow and hematologic disorders.

Other Institutes of the NIH are responsible for research on disorders

of white cells, including the leukemias and other blood malignancies,

and basic immunology related to the lymphoid system.  Therefore, NHLBI

cannot provide support for such studies.





NIH and ADAMHA policy is that applicants for NIH/ADAMHA clinical

research grants and cooperative agreements are required to include

minorities and women is study populations so that research finds can be

of benefits to all persons at risk of the disease, disorder or

condition under study; special emphasis must be placed on the need for

inclusion of minorities and women in studies of diseases, disorders and

conditions which disproportionately affect them.  This policy is

intended to apply to males and females of all ages.  If women or

minorities are excluded or inadequately represented in clinical

research, particularly in proposed population-based studies, a clear

compelling rationale must be provided.

The composition of the proposed study population must be described in

terms of gender and racial/ethnic group.  In addition, gender and

racial/ethnic issues should be addressed in developing a research

design and sample size appropriate for the scientific objectives of the

study.  This information must be included in the form PHS 398 in

Sections 1-4 of the Research Plan AND summarized in Section 5, Human

Subjects.  Applicants are urged to assess carefully the feasibility of

including the broadest possible representation of minority groups.

However, NIH recognizes that it may not be feasible or appropriate in

all research projects to include representation of the full array of

United States racial/ethnic minority populations (i.e., Native American

(including American Indians or Alaskan Natives), Asian/Pacific

Islanders, Blacks, Hispanics).  The rationale for studies on single

minority population groups must be provided.

For the purpose of this policy, clinical research is defined as human

biomedical and behavioral studies of etiology, epidemiology, prevention

(and preventive strategies), diagnosis, or treatment of diseases,

disorders or conditions, including but not limited to clinical trials.

The usual NIH policies concerning research on human subjects also

apply.  Basic research or clinical studies in which human tissues

cannot be identified or linked to individuals are excluded.  However,

every effort should be made to include human tissues from women and

racial/ethnic minorities when it is important to apply the results of

the study broadly, and this should be addressed by applicants.

If the required information is not contained within the application,

the review will be deferred until the information is provided.

Peer reviewers will address specifically whether the research plan in

the application conforms to these policies.  If the representation of

women or minorities in a study design is inadequate to answer the

scientific question(s) addressed AND the justification for the selected

study population is inadequate, it will be considered a scientific

weakness or deficiency in the study design and will be reflected in

assigning the priority score to the application.

All applications for clinical research submitted to NIH are required to

address these policies.  NIH funding components will not award grants

or cooperative agreements that do not comply with these policies.


Each prospective applicant is requested to forward a letter of intent

that includes a descriptive title, the name and address of the research

mentor, and any other participating institutions.  Such letters are

requested for the purposes of obtaining an indication of the number and

scope of the applications to be reviewed.  A letter of intent is not

binding, is not a requirement of submission, and does not enter into

the review of the application.

The letter of intent is requested by July 1, 1992, and is to be

addressed to:

Scientific Review Administrator

Research Training Review Committee

Division of Extramural Affairs

National Heart, Lung, and Blood Institute

Westwood Building, Room 550

Bethesda, MD  20892


Applications are to be submitted on the grant application form PHS 398

(rev. 9/91).  Application kits are available at most institutional

business offices and may be obtained from the Office of Grants

Inquires, Division of Research Grants, National Institutes of Health,

Westwood Building, Room 449, Bethesda, MD  20892 (telephone


Applicants are advised to obtain the NHLBI Guidelines from the contact

listed in "INQUIRIES" before preparing an application.

The title and number of the announcement must be typed in section 2a on

the face page of the application.

The commitment of the institution to the faculty candidate's research

and development must clearly be presented in the application.  This

should include statement(s) from the Dean and departmental chair

indicating that the candidate will be provided with sufficient release

time from other duties to accomplish the research goals stated in the


The completed original application and three legible copies must be

sent or delivered to:

Division of Research Grants

National Institutes of Health

Westwood Building, Room 240

Bethesda, MD  20892**

Two additional copies of the application must be sent to the Scientific

Review Administrator of the Research Training Review Committee listed


Applications must be received on or before August 24, 1992.

Applications received after this date will be returned to the applicant

without review.


All applications will be reviewed for scientific and technical merit by

the Research Training Review Committee of the Division of Extramural

Affairs, NHLBI, followed by a second level review by the National

Heart, Lung, and Blood Advisory Council.


Applications will compete for available funds with other approved

career development award applications assigned to the NHLBI.  The

following will be considered in making funding decisions:

o Technical merit of the application as determined by peer review

o Availability of funds

o Program balance among the research areas of the announcement


Written and telephone inquires are encouraged.  Guidelines for this

program may be obtained from any of the following:

John Fakunding, Ph.D.

Division of Heart and Vascular Diseases

National Heart, Lung and Blood Institute

Federal Building, Room 3C04

Bethesda, MD  20892

Telephone:  (301) 496-1724

Helena Mishoe, Ph.D.

Division of Blood Diseases and Resources

National Heart, Lung and Blood Institute

Federal Building, Room 504

Bethesda, MD  20892

Telephone:  (301) 496-6931

Mary Reilly, M.S.

Division of Lung Diseases

National Heart, Lung, and Blood Institute

Westwood Building, Room 640A

Bethesda, MD  20892

Telephone:  (301) 496-7668

For fiscal and administrative matters, contact:

Jane Davis

Grants Operations Branch

Division of Extramural Affairs

National Heart, Lung, and Blood Institute

Westwood Building, Room 4A15C

Bethesda, MD  20892

Telephone:  (301) 496-7257


This program is described in the Catalog of Federal Domestic Assistance

Nos. 93.837, 93.838, and 93.839.  Awards will be made under the

authority of the Public Health Service Act, Title III, Section 301

(Public Law 78-410, as amended; 42 USC 241) and administered under PHS

grants policies and Federal Regulations at 42 CFR Part 52 and 45 CFR

Part 74.  This program is not subject to the intergovernmental review

requirements of Executive Order 12372 or Health Systems Agency review.


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