TRAINING AND DEVELOPMENT: NURSING AND BIOLOGY INTERFACE PA: PA-92-35 P.T. 44 Keywords: Nursing Biological Sciences Clinical Medicine, General National Center for Nursing Research PURPOSE This program announcement identifies specific research training and career development support mechanisms for the purpose of integrating biological theory, measurements, and techniques with nursing research and practice. Applicants must focus on basic biological investigations pertaining to nursing clinical questions, technological and/or clinical protocols, and nursing research based on biobehavioral theories, measurements, and techniques. ELIGIBILITY REQUIREMENTS All policies and requirements that govern the grant programs of the Public Health Service apply. Applicants must meet the respective criteria for the Individual National Research Service Awards (NRSA) or the Clinical Investigator and Academic Investigator Awards as stipulated by the National Center for Nursing Research (NCNR) and PHS policy. Applications from minority individuals and women are encouraged. MECHANISMS OF SUPPORT The mechanisms of support for this program will be the Individual Predoctoral NRSA fellowship (F31); the Individual Postdoctoral NRSA fellowship (F32); the NRSA Senior Fellowship (F33); training positions on existing Institutional NRSA research training grants (T32s) funded by other NIH components; the NCNR Academic Investigator Award (K07); and the NCNR Clinical Investigator Award (KO8). The regulations that govern the research training and career development programs of the Public Health Service and NCNR will prevail. RESEARCH OBJECTIVES An important focus of nursing research in the improvement of patient care is the interaction of biological and behavioral factors associated with acute and chronic illness and health promotion and disease prevention. NCNR believes that in order to explore this biobehavioral interface, training and career development resources must be focused on areas of biological science that underlie nursing practice. Recognizing the rapid changes that are taking place in the biomedical sciences and the effect these changes will have on nursing research and practice, the biological content of the NCNR portfolio was analyzed. Nurse physiologists comprising the Biological Task Force recommended strategies to integrate nursing research with state-of-the-art biological science. These recommendations were approved by the National Advisory Council for Nursing Research. A long-range plan for implementing the Task Force's recommendations includes research initiatives to increase the interface of biological sciences with nursing research as a basis for clinical practice and education. The first step in this plan is to increase opportunities for research training and career development in the biological sciences. The specific objectives of NCNR research training and career development in the biological sciences are: 1) to develop a cadre of nurse scientists with research training at the predoctoral and postdoctoral level in the biological science; and 2) to enhance the knowledge base of doctorally prepared mid-career nurses whose research involves biological science. Examples of biological science disciplines are physiology, pharmacology, anatomy, biochemistry, molecular biology, genetics, pathology, and/or immunology. The overall goal of this training initiative is to increase the number of nurse researchers in the biological sciences prepared to explore the biological underpinnings of nursing practice and research. To accomplish this goal, it is mandatory for each applicant to include a nurse scientist as a co-sponsor when the biological scientist does not have a nursing degree. Opportunities for nurse scientists to collaborate with biological scientists from other disciplines are encouraged. Training and career development programs should provide opportunities for nurses to conduct supervised clinical and basic biological research with the primary objective of extending their research skills and knowledge to the interface between nursing and one of the biological disciplines. The academic, clinical, and laboratory environment should facilitate growth and development for promising students, new research scientists, and mid-career scientists. Examples of important training opportunities include ongoing interactive departmental seminars, a faculty well published in refereed journals, and an interactive, interdisciplinary research team with multiple funding sources including an established sponsor with a funded program of research. Extraordinary advances in scientific knowledge have confirmed the essential unity of basic biological and behavioral research. Behavioral research, mental health research, and psychosocial research can no longer be considered as separate from genetics, molecular biology, and immunology. For example, information processing by the brain is a major factor in behavioral disorders and stress reactions. The autonomic nervous system can be modified through cognitive techniques such as biofeedback and relaxation. New fields such as psychoneuroimmunology focus on the integral relationships and reciprocal interactions of the immune, nervous, and endocrine systems and other systems of the body that affect health and well-being. o Targeted Predoctoral (F31) and Postdoctoral (F32) Fellowshipships and Targeted Senior Fellows (F33) The F31, F32, and F33 biological science fellowships will focus on biomedical science development, advanced clinical science development, and supervised research training experience. Applicants must integrate an area of biological theory with a relevant nursing problem. For example, postdoctoral studies in biochemistry targeting gluconeogenesis would be relevant to the nursing problem of caring for critically injured multiple trauma patients who experience severe organ failure. It is necessary that sponsor(s) be either a biological nurse scientist or a biological scientist with a nurse scientist as co-sponsor. The F31 predoctoral biological science fellowship is designed to provide predoctoral nurses with supervised clinical and/or basic biological research training leading to the Ph.D. Applicants must be registered nurses. The F32 postdoctoral biological science fellowship, a priority of the NCNR, is designed to provide postdoctoral research training to nurse scientists to refine their research interests, initiate independent research programs, and to gain depth of knowledge in their clinical and/or basic biological research area. In order to prepare scientists to explore the biological underpinnings of nursing practice and research, applicants must integrate biological science with a nursing problem or a clinical practice issue. Priority status will be given to nurses with doctorates who submit a successful postdoctoral NRSA application enabling continued training without a time break. To ensure maximum growth and development as a research scientist and to increase the integration of new theories and ideas, postdoctoral fellows are advised to choose universities or departments other than the site of their doctoral training. The F33 senior biological science fellowship award is designed to provide advanced training for experienced nurse scientists (with at least seven years of relevant research experience beyond the doctoral level). These awards will enable nurse scientists to take time from regular professional responsibilities and to make major changes in the direction of their research careers or to broaden their scientific background by acquiring new research capabilities. This award is directed at nurse researchers well prepared in biological science who desire to learn new methodologies and techniques. For example, a nurse scientist might combine sabbatical time with F33 funding to investigate the biobehavioral link between depression and lymphocyte function in chronically ill patients. Meritorious applications that are responsive to the objectives of this program announcement will be given high program relevance. o Training Positions on Existing Institutional Training Grants (T32) Currently Funded by Other NIH Institutes, Centers and Divisions Existing institutional training grants within NIH may provide nurse scientists predoctoral and postdoctoral opportunities for biomedical research training. These traineeships are designed to place qualified individuals in biomedical science environments. Candidates must have co-sponsors with nurse scientists when mentorship with biological nurse scientists is not possible. Nurse candidates are advised to contact the T32 Principal Investigator directly to discuss potential predoctoral or postdoctoral opportunities. o Targeted Mid-Career Academic (K07) and Clinical Investigator (K08) Award The purpose of these targeted awards is two-fold: (1) to teach biological measurements and techniques to accomplished nurse researchers who have little formal training in biological science but conduct research in a biobehavioral framework; and (2) to teach accomplished nurse biological researchers state-of-the-science biological research, especially cutting edge biological technology and bioinstrumentation applicable to nursing research and practice. To ensure a commitment to nursing research and in order to achieve an effective interface between the biological and nursing foci, the candidate must have a nurse scientist as a co-sponsor when the basic biological scientist or clinically trained scientist is not a nurse. The objectives of these mechanisms are to interface biological science with nursing research, with a focus on clinical practice. These targeted awards are designed to provide mid-career development in molecular biology, physiology, anatomy, biochemistry, genetics, pathology, pharmacology, and immunology. The NCNR KO7 mechanism allows promising nursing faculty to take time from administrative and teaching duties to establish research programs and mature into independent investigators. The candidate must be sponsored by a basic biological scientist who is recognized as an established investigator in the research area proposed, who has had experience in training independent investigators, and who will provide the mentorship required in the respective dimension of biological science. The NCNR KO8 mechanism enables promising clinically trained individuals with a doctoral degree to become independent scientists under a sponsor. Applicants from institutions that have a GCRC funded by the NIH National Center for Research Resources (NCRR) may wish to identify the GCRC as a resource for conducting the proposed research. A letter of agreement from either the GCRC program director or Principal Investigator of the NIH-supported program must be included with the application. NCNR guidelines for the standard KO7 and KO8 mechanisms have been published in the NIH Guide for Grants and Contracts, Volume 20, No. 20, May 24, 1991. In addition to the established KO7 and KO8 mechanisms, the usual guidelines of four to eight years beyond the doctorate may be waived for nurse scientists who have been Principal Investigators in the past or may be a current Principal Investigator of a research grant (R01). If a candidates exceeds the eight-year limit stipulated in the guidelines, an explanation of special qualifying circumstances must be provided in the application. Meritorious applications that are responsive to the objectives of this program announcement will be given high program relevance. STUDY POPULATIONS It is the NIH policy that women and minorities must be included in clinical study populations. The study design must seek to identify any pertinent gender or minority population differences. REVIEW PROCEDURES Applications in response to this announcement will be reviewed in competition with other applications and in accord with the customary NIH peer review procedures and criteria. Applications will be reviewed for scientific and technical merit by an initial review group. Second level review for the Career Development (K07, K08) awards will be conducted by an appropriate national advisory council. Second level review of individual fellowship (F31, F32, F33, T32) applications will be conducted by an appropriate Executive Review Group. APPLICATION PROCEDURES Applicants for individual NRSA fellowships must use form PHS 416-1 (rev. 4/89). Career Development Award applicants must use PHS 398 (rev. 10/88). In order to expedite processing of the applications indicate that this is in response to this program announcement on line 3 of the PHS 416-1 face page; and line 2 of the PHS 398 face page. Applications must be submitted to the Division of Research Grants in accordance with the usual receipt dates. The mailing address is: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892 INQUIRES Written and telephone inquiries concerning this program announcement are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquires regarding programmatic issues to: Hilary D. Sigmon, Ph.D., R.N. Nurse Scientist Administrator National Center for Nursing Research Building 31, Room 5B03 Bethesda, MD 20892 Telephone: (301) 496-0523 Direct inquiries regarding fiscal matters to: Ms. Sally Nichols Grants Management Officer National Center for Nursing Research Building 31, Room 5B06 Bethesda, MD 20892 Telephone: (301) 496-0237 AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.361, Nursing Research. Awards are made under the authority of the PHS Act, Sections, 301, 483, 484, 485, and 487 as amended by Public Law 99-158 and 97-219. Awards are administered under PHS grants policies and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. .
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