Release Date:  December 20, 2000 (This announcement has been superceded by 

PA NUMBER:  PA-01-037

National Institute on Aging

Application Receipt Dates:  March 20, 2001, July 17, 2001, November 16, 2001



The National Institute on Aging (NIA) is seeking small grant (R03) 
applications in specific areas to: (1) stimulate and facilitate the 
entry of promising new investigators into aging research, and (2) 
encourage established investigators to enter new targeted, high 
priority areas in this research field.  This Small Grant (R03) Program 
provides support for pilot research that is likely to lead to a 
subsequent individual research project grant (R01) that is focused on 
aging and/or a significant advancement of aging research. 


The Public Health Service (PHS) is committed to achieving the health 
promotion and disease prevention objectives of "Healthy People 2010," a 
PHS led national activity for setting priority areas. This Program 
Announcement (PA), the NIA PILOT RESEARCH GRANT PROGRAM, is related to 
one or more of the priority areas. Potential applicants may obtain a 
copy of "Healthy People 2010" at


Applications may be submitted by domestic for-profit and non-profit 
organizations, public and private, such as universities, colleges, 
hospitals, laboratories, units of State and local governments, and 
eligible agencies of the Federal government.  Racial/ethnic minority 
individuals, women, and persons with disabilities are encouraged to 
apply as principal investigators.  Foreign organizations and 
institutions are not eligible.  Participation in the program by 
investigators at minority institutions is strongly encouraged. 

New or established investigators are eligible to apply for this award. 
(1) Investigators are considered new when they are neither current nor 
former principal investigators on NIH research project (R01), FIRST 
Awards (R29), sub-projects of program project (P01) or center grants 
(P50), and the equivalent. If the applicant is in the final stages of 
training it is permissible to apply for an R03 but no award will be 
made to individuals who are still in training or fellowship status at 
the time of award (see reference to Biographical sketch under 
Application Procedures). (2) For an established investigator to be 
eligible the individual must propose research that is unrelated to any 
federally-funded research project in which the investigator 


Applicants may request either $25,000 or $50,000 in direct costs for 
one year through the small grant (R03) mechanism.  These awards are not 
renewable. Before completion of the R03, investigators are encouraged 
to seek continuing support for research through a research project 
grant (R01).  Specific application instructions have been modified to 
reflect "MODULAR GRANT" and "JUST-IN-TIME" streamlining efforts being 
examined by NIH. Complete and detailed instructions and information on 
Modular Grant applications can be found at: 

Replacement of the Principal Investigator on this award is not 
permitted.  Revisions of applications previously reviewed under this 
initiative but unfunded are not permitted.  A new application must be 
substantially different from one previously reviewed and have a 
different title in order to be accepted for review. It must focus on 
one of the topics in the announcement that is active when the new 
application is submitted. All applications will be reviewed as new 


Investigators may apply for a small grant in one of the following 
areas.  Applications for support in other areas will be returned to the 
proposed Principal Investigator without review.  Investigators should 
follow the instructions described under APPLICATION PROCEDURES to 
identify the topic on which the application is focused. 

1. HIV/AIDS and Aging:  Behavioral, social, clinical, neuroscientific, 
and/or biological research on older people infected by, and affected 
by, HIV/AIDS.  Also social, economic, and health consequences of 
HIV/AIDS for older persons as parents and relatives of HIV infected 
adults, in both developed and developing countries. Prevention sciences 
research is encouraged, and both basic and applied research are 

2.  Racial/Ethnic Differences and Health Disparities:  (a) Research 
leading to identification of underlying mechanisms, including cellular 
and molecular mechanisms, linked to racial/ethnic differences in late 
life function or disease e.g. cognition, Alzheimer"s disease, 
cardiovascular disease, cancer, infectious diseases, and diabetes. (b) 
Research to disentangle the effects of socio-economic status, social 
and environmental factors, health behaviors, and race and ethnicity on 
health, and (c) Research to develop and improve instruments and 
methods, including standardization across population groups, to measure 
disorders, disease and disability in minority groups that will lead to 
an understanding of the causes of these conditions. NIA"s strategic 
plan for addressing health disparities is available from: 

3. Cardiovascular and Cerebrovascular aging: Behavioral, social, 
cellular, and molecular studies of cardiovascular and cerebrovascular 
aging.  N.B. Applications for clinical studies, exclusively on the 
aging cardiovascular system, will not be accepted in response to this 

4. Stems Cells, Tissue Repair, and Cell Replacement in Aging:  Studies 
on the biology of stem cells as a function of aging and disease, 
genetic and 
environmental effects on tissue stem cells, stem cell plasticity, 
development of cell markers and imaging techniques to identify and 
monitor stem cells in vivo, and 
transplantation of stem cells to effect tissue repair. NIH has 
published policy guidelines for research using human pluripotent stem 
cells and has published procedures to be used in applying for NIH 
research funding for this activity. See: and

5. Neural Modeling:  Studies to develop computational neural-network 
models of neural changes with age that impact behavioral outcomes of 
memory, learning, sensory function, and motor function as well as 

6. Sensory and Motor Processing:  Mechanisms underlying age-related 
changes in sensory and motor processing in the central nervous system.

7. Cognition in Context: Studies to understand how differences in 
contexts produce systematic variation in cognitive functioning and 
performance that are often attributed to sociocultural categories 
(e.g., social class, occupation, ethnicity, educational attainment).  
Of particular interest is what happens in the contexts of school, 
workplace, or social networks to shape the mind and brain, bringing 
about systematic intergroup differences in cognition that endure 
through the life span.  

8. Alzheimer"s Disease Drug Discovery:  Studies for preclinical 
research in the discovery, design, development and testing of novel 
compounds aimed at immunological and other approaches to delaying 
decline in cognitive function, and to preventing, slowing the 
progression of, or delaying the onset of Alzheimer’s disease. 

9. Extracellular Matrix and Cytoskeleton: Studies on age-related 
changes in the structure, content, or function of the extracellular 
matrix and cytoskeleton, including regulation of cell signaling 
cascades, intracellular transport mechanisms, cell motility and 
morphology, and cell death. 

10. Functional Senescence: Genetic, cellular and biochemical mechanisms 
underlying age-related changes in tissues or organs leading to 

11. Psychoneuroimmunology: Studies of how neural and neuroendocrine 
mechanisms interact with immune pathways to modulate the aging immune 
system response to psychological and pathological challenges, and 
studies to understand the mechanisms underlying "placebo" effects with 

12. Vaccine Development: Preliminary basic and clinical studies, and 
therapeutic trials of vaccines for use in elderly populations.  
Vaccines may be prophylactic or therapeutic in nature.  These may 
include studies of methods to enhance the immune response in older 
persons including alternative administration schedules with existing 
vaccines, the use of adjuvants, and/or new vaccines.  

13. Health-related Consequences of Female Reproductive Aging: Basic 
molecular and cellular research to elucidate underlying neuroendocrine, 
endocrine and physiologic mechanisms of the female reproductive aging 
process, especially 1) changes across the hypothalamic-pituitary-
ovarian axis leading to menopause in women, 2) hormonal and other 
changes in the menopausal process associated with increased risk for 
peri- and postmenopausal health problems and conditions, and 3) age-
related changes in the biology of hormone action and metabolism.

14. Biology of Age-related Prostate Growth: Basic molecular and 
cellular research to explore underlying mechanisms responsible for 
prostate growth in men leading to benign prostatic hyperplasia and 
prostate cancer. 

15. Cancer in the elderly:  Studies in persons aged 70 years and older 
regarding incidence, survival, and clinical impact in cancers of the 
breast, prostate, colorectal, lung, ovarian, and pancreas are 
encouraged.  Research topics include tumor-related tissue studies, 
autopsy investigations, characterization of cancer as it interfaces 
with pre-existing health conditions (i.e., comorbidity), overcoming the 
practical problems of acquiring data on this age segment of cancer 
patients, and quality of survival.  Studies with a focus on home and/or 
nursing home settings are appropriate. Patterns of care and treatment, 
development of clinical evaluation tools specific for the elderly 
(e.g., prognostic indicators, geriatric assessment) that can be used by 
physicians to determine the patients’ overall physical and physiologic 
health status are also included in this solicitation. 

16. Metabolic Regulation: Studies that explore whether intermediary 
metabolism changes with advancing age and/or caloric restriction, and 
whether there is a relationship between age-related and caloric 
restriction-related changes in metabolism.  N.B. Applications for 
clinical studies in this area will not be accepted in response to this 

17. Basic Underlying Mechanisms of Musculoskeletal Aging (muscle, bone, 
cartilage, neuromuscular junction, peripheral nerve, and motorneuron):  
Applications for clinical studies on the aging musculoskeletal system 
will be considered non-responsive to this research bullet. 
Investigators interested in submitting exploratory/pilot clinical 
studies of the aging musculoskeletal system are encouraged to contact 
the Geriatrics Program (E-mail: to 
explore other options. 

18. Animal Models of Aging: Development of new and informative animal 
models for aging research, including genetically defined and or 
genetically altered animals. 
19. Tools for Research on the Genetics of Aging: Development of tools 
such as cDNA full length libraries, single nucleotide polymorphism 
(SNP) analysis, and conditional gene expression systems for studying 
the genetic basis of aging. High priority will be given to proposals to 
demonstrate proof of principle using high throughput technology, e.g., 
microarrays, to obtain data on age-related changes in gene expression 
or DNA sequence in addressing questions of gerontological significance. 

20. Genetic Epidemiology:  Studies to understand the genetic and 
environmental basis of complex traits associated with behavioral and 
functional aging. Such studies may include but are not limited to: the 
application of new analytic strategies to study complex traits or rates 
of change, approaches to identify and investigate QTL effects, and 
preliminary studies exploring how behaviors or environmental risk 
factors, such as stress, affect gene expression. Research into the 
psychosocial effects, including the within-family intergenerational 
impact, of genetic testing and genetic screening is also encouraged. 
Pilot studies for linkage of two or more data sets to facilitate larger 
sampling frames by combining familial, health, and psychosocial 
information are also of interest.

21. Pilot Data Collection in Population Aging:  Feasibility studies 
and/or new pilot data collection leading to large-scale, new, or 
enhanced studies on retirement, health disparities, trends in 
disability, transitions across long-term care settings, biodemography, 
and early determinants of late-life health.

22.  Improved Measures and Methodologies:  Improved measures are 
especially needed of adaptation and well-being over the course of 
chronic diseases, and following major life events and transitions, 
including methods that reconcile objective and subjective measures of 
well-being.  Summary measures of cumulative social, psychological and 
cultural advantage or adversity, and experienced discrimination, are 
needed. Cross-national studies to harmonize and validate measures are 
encouraged.   Innovative methods are needed to meld laboratory, 
clinical or ethnographic approaches with large-scale population 
studies, including the use of experience-based sampling and the 
addition of bio-indicators to social science surveys.  New 
methodologies to assess progress in the social and behavioral sciences 
of aging (e.g., creation of new areas, dissemination to other areas of 
science, and the impact of research on public policy and well-being) 
are encouraged.  

23. Personality, Experimental Social Psychology, and Health 
Interventions:  Applications are solicited for genetic determinants of 
personality traits, personality and social processes, and the role of 
personality in health outcomes.  Pilot studies are especially needed 
that experiment with integrating interventions at the physiological, 
psychological, social structural and economic levels.  Pilot tests are 
needed of innovative multi-level social and behavioral interventions to 
enhance social, psychological and economic well-being, as well as 
specific lifestyle, self-management and caregiving behaviors.  Studies 
examining personality and other individual differences that mediate the 
effectiveness of behavioral interventions are also encouraged.   
Preliminary studies describing the impact of social relationships on 
cognitive decline, exploring mediating pathways (including biological), 
and suggesting possible new interventions are encouraged.

24. Work, Older Workers, and Organizations:  Research is encouraged on 
the demographic, economic, social, psychological, and human factors 
aspects of older workers in the workplace, with special attention to 
the impact of the wide variety of workplace environments and 
experiences on older worker health and cognition.  Studies of employees 
of nursing homes and other long-term care settings are particularly 
encouraged, as well as studies of the impact of employee 
characteristics (including stereotypes of aging) on patients.  Also 
encouraged are studies of minorities in supervisory positions (e.g. in 
the military or the US civil service) to test whether or not the 
health/SES gradient found in the U.K. Whitehall Study holds in the US 
and whether or not supervisory roles mitigate against the impact of 
negative risk factors on health.

The National Institute on Aging will modify the selected topic areas 
annually by reissuing the program announcement. Information on other 
initiatives supported by NIA may be found at the following internet 


It is the policy of the NIH that women and members of minority groups 
and their sub-populations must be included in all NIH-supported 
biomedical and behavioral research projects involving human subjects, 
unless a clear and compelling rationale and justification are provided 
indicating that inclusion is inappropriate with respect to the health 
of the subjects or the purpose of the research.  This policy results 
from the NIH Revitalization Act of 1993 (Section 492B of Public Law 

All investigators proposing research involving human subjects should 
read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities 
as Subjects in Clinical Research," published in the NIH Guide for 
Grants and Contracts on August 2, 2000 
(, a 
complete copy of the updated Guidelines are available at  
The revisions relate to NIH defined Phase III clinical trials and 
require: a) all applications or proposals and/or protocols to provide a 
description of plans to conduct analyses, as appropriate, to address 
differences by sex/gender and/or racial/ethnic groups, including 
subgroups if applicable, and b) all investigators to report accrual, 
and to conduct and report analyses, as appropriate, by sex/gender 
and/or racial/ethnic group differences.


All applications and proposals for NIH funding must be self-contained 
within specified page limitations.  Unless otherwise specified in an 
NIH solicitation, internet addresses (URLs) should not be used to 
provide information necessary to the review because reviewers are under 
no obligation to view the Internet sites.  Reviewers are cautioned that 
their anonymity may be compromised when they directly access an 
Internet site.


Applications are to be submitted on the grant application form PHS 398 
(rev. 4/98) and prepared according to the directions in the application 
packet, with the exceptions noted below.  Application kits are 
available at most institutional offices of sponsored research and may 
be obtained from the Division of Extramural Outreach and Information 
Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 
7910, Bethesda, MD 20892-7910, telephone (301) 710-0267, FAX (301) 480-
0525, Email: Applications are also available on the 
internet at 

On the face page of the application: Item 2 Type "NIA: PILOT RESEARCH 
GRANT PROGRAM" and the number of the program announcement. Check the 
"YES" box. 

Abstract: The first line of the abstract must list the number and title 
of the particular research topic (see RESEARCH OBJECTIVES) being 
responded to.  

Biographical sketch (also see below under modular procedures): 
Applicants who remain in training or in fellowship status at the time 
of application should list in their biographical sketch the position 
they will occupy at the time of award with the expected start date in 
that position. If the position is contingent on receipt of the award 
then it should be described as "contingent on award". 

Research plan: Do not exceed a total of ten pages for the following 
parts (a-d): Specific Aims, Background and Significance, Progress 
Report/Preliminary Studies, and Experimental Design and Methods.  
Tables and figures are included in the ten page limitation.  
Applications that exceed the page limitation or PHS requirements for 
type size and margins  (Refer to PHS 398 application for details) will 
be returned to the investigator.  The ten page limitation does not 
include parts e through i. (Human Subjects, Vertebrate Animals, 
Literature Cited, Consortium Arrangements, Consultants). 

Appendix: The only items that may be included in an appendix are 
original glossy photographs or color images of gels, micrographs, etc., 
provided that a photocopy (that may be reduced in size) is also 
included within the 10 page limit of items a-d in the research plan. No 
photographs or color images may be included in the appendix that are 
not also represented in the Research Plan. Do not include publications 
or preprints. 

Materials submitted after the receipt date. No additional materials 
pertaining to a particular application will be accepted after the 
receipt date for which the application is submitted except for 
certifications of Institutional Review Board (IRB) or Institutional 
Animal Care and Use Committee (IACUC) approval. As specified in the PHS 
398 form, certifications of IACUC approval must be received within 60 
days after the receipt date for which the application is submitted. IRB 
approval is no longer required prior to review. Institutions should 
proceed with IRB review of those applications identified as in the 
fundable range following review. See 

The NIA pilot grant program will follow modular procedures (See for 
application and award. The modular grant concept establishes specific 
modules in which direct costs may be requested as well as a maximum 
level for requested budgets. Only limited budgetary information is 
required under this approach. The just-in-time concept allows 
applicants to submit certain information only when there is a 
possibility for an award. It is anticipated that these changes will 
reduce the administrative burden for the applicants, reviewers and 
Institute staff. The research grant application form PHS 398 (rev. 
4/98) is to be used in applying for these grants, with the 
modifications noted below. 


Applications in response to this announcement should request either 
$25,000 in total direct costs or $50,000 in total direct costs. The 
total direct costs must be requested in accordance with the program 
guidelines and the modifications made to the standard PHS 398 
application instructions described below: 

PHS 398 

o  FACE PAGE:  Items 7a and 7b should be completed, indicating Direct 
Costs (either $25,000 or $50,000) and Total Costs [Modular Total Direct 
Facilities and Administrative (F&A) costs] for the initial budget 
period.  As these are one year applications items 8a and 8b should show 
the same amounts 
as items 7a and 7b. 

Page 4 of the PHS 398.  It is not required and will not be accepted 
with the application. 

the categorical budget table on Form Page 5 of the PHS 398.  It is not 
required and will not be accepted with the application. 

o  NARRATIVE BUDGET JUSTIFICATION - Prepare a Modular Grant Budget 
Narrative page. (See for sample 
pages.)  At the top of the page, enter the total direct costs requested 
for the award. This is not a Form page. 

o  Under Personnel, list all project personnel, including their names, 
percent of effort, and roles on the project. No individual salary 
information should be provided. However, the applicant should use the 
NIH appropriation language salary cap and the NIH policy for graduate 
student compensation in developing the budget request.

For Consortium/Contractual costs, provide an estimate of total costs 
(direct plus facilities and administrative) rounded to the nearest 
$1,000.  List the individuals/ organizations with whom consortium or 
contractual arrangements have been made, the percent effort of all 
personnel, and the role on the project. Indicate whether the 
collaborating institution is foreign or domestic. The total cost for a  
consortium/contractual arrangement is included in the overall requested 
modular direct cost amount. Include the Letter of Intent to establish a 

o  BIOGRAPHICAL SKETCH - The Biographical Sketch provides information 
used by reviewers in the assessment of each individual"s qualifications 
for a specific role in the proposed project, as well as to evaluate the 
overall qualifications of the research team.  A biographical sketch is 
required for all key personnel, following the instructions below.  No 
more than three pages may be used for each person.  A sample 
biographical sketch may be viewed at: 

- Complete the educational block at the top of the form page, - List 
position(s) and any honors, - Provide information, including overall 
goals and responsibilities, on research projects ongoing or completed 
during the last three years, - List selected peer-reviewed 
publications, with full citations. 

o  CHECKLIST - This page should be completed and submitted with the 
application.  If the F&A rate agreement has been established, indicate 
the type of agreement and the date. All appropriate exclusions must be 
applied in the calculation of the F&A costs for the initial budget 
period and all future budget years. 

o  The applicant should provide the name and phone number of the 
individual to contact concerning fiscal and administrative issues if 
additional information is necessary following the initial review.   
Submit a signed, original of the application, and three exact 
photocopies, including the checklist, in one package to: 

6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC-7710
BETHESDA, MD  20892-7710
BETHESDA, MD  20817 (for express/courier service) 

In addition, to prepare for review of the application, submit two 
additional exact photocopies of the application directly to: 

Dr. Mary Nekola
Scientific Review Office
National Institute on Aging
7201 Wisconsin Avenue, Suite 2C212, MSC 9205
Bethesda, MD  20892-9205 

It is important that applicants submit two additional copies to the 
Scientific Review Office as requested.  Amended applications will not 
be accepted. 

The submission, review, and award schedule for the Pilot Research Grant 
Program for 2001 is: 

Application Receipt Dates:   03/20/2001   07/17/2001   11/16/2001
Institute Committee Review:  Jun-Jul      Oct-Nov      Feb-Mar
Earliest Funding:            Sep 2001     Jan 2002     May 2002 

Only one Small Grant application may be submitted by a Principal 
Investigator per receipt date in response to this program announcement. 


Upon receipt, applications will be reviewed for completeness by CSR. 
Applications for this PA must focus on one of the 24 topics identified. 
Incomplete applications will be returned to the applicant without 
further consideration.  Applications that are complete will be 
evaluated for scientific and technical merit by an appropriate peer 
review group convened by the NIA in accordance with the review criteria 
stated below. As part of  the initial merit review, all applications 
will receive a written critique and may undergo a process in which only 
those applications deemed to have the highest scientific merit, 
generally the top half of applications under review, will be discussed, 
and assigned a priority score. 

Review Criteria 

The goals of NIH-supported research are to advance our understanding of 
biological systems, improve the control of disease, and enhance health.  
In the written review, comments on the following aspects of the 
application will be made in order to judge the likelihood that the 
proposed research will have a substantial impact on the pursuit of 
these goals. Each of these criteria will be addressed and considered by 
the reviewers in assigning the overall score weighting them as 
appropriate for each application. Note that the application does not 
need to be strong in all categories to be judged likely to have a major 
scientific impact and thus deserve a high priority score. For example, 
an investigator may propose to carry out important work that by its 
nature is not innovative but is essential to move a field forward. 

1.  Significance.  Does this study address an important problem? If the 
aims of the application are achieved, how will scientific knowledge be 
advanced?  What will be the effect of these studies on the concepts or 
methods that drive this field? 

2.  Approach.  Are the conceptual framework, design, methods, and 
analyses adequately developed, well-integrated, and appropriate to the 
aims of a pilot project?  Does the applicant acknowledge potential 
problem areas and consider alternative tactics? 

3.  Innovation.  Does the project employ novel concepts, approaches or 
method? Are the aims original and innovative? Does the project 
challenge existing paradigms or develop new methodologies or 

4.  Investigator.  Is the investigator appropriately trained and well 
suited to carry out this work?  Is the work proposed appropriate to the 
experience level of the principal investigator and other researchers 
(if any)? 

5.  Environment.  Does the scientific environment in which the work 
will be done contribute to the probability of success?  Do the proposed 
experiments take advantage of unique features of the scientific 
environment or employ useful collaborative arrangements?  Is there 
evidence of institutional support? 

The initial review group will also examine: the likelihood that the 
pilot project will lead to the development of an R01 application, or 
significant advancement of aging research, the appropriateness of 
proposed project budget and duration, the adequacy of plans to include 
both genders and minorities and their subgroups as appropriate for the 
scientific goals of the research and plans for the recruitment and 
retention of subjects, the provisions for the protection of human and 
animal subjects, and the safety of the research 


Applications will compete for available funds with all other approved 
applications.  The following will be considered in making funding 

o  quality of the proposed project as determined by peer review 
o  availability of funds 
o  program priority 


Inquiries are encouraged.  The opportunity to clarify any issues or 
questions from potential applicants is welcome. 

For applications with primary emphasis on the biology of aging contact: 

Dr. David B. Finkelstein
Biology of Aging Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 2C231, MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 496-6402
FAX:  (301) 402-0010

For applications with primary emphasis on behavioral or social research 
on aging contact: 

Ms. Angie Chon-Lee
Behavioral and Social Research Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 5C533, MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 594-5943
FAX:  (301) 402-0051

For applications with primary emphasis on the neuroscience or 
neuropsychology of aging contact: 

Dr. Judy Finkelstein
Neuroscience and Neuropsychology of Aging Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 3C307, MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 496-9350
FAX:  (301) 496-1494

For applications with primary emphasis on geriatrics research contact: 

Ms. Wanda Solomon
Geriatrics Program
National Institute on Aging
7201 Wisconsin Avenue, Suite 3E327 MSC 9205
Bethesda, MD  20892-9205
Telephone:  (301) 435-3046
FAX:  (301) 402-1784

Direct inquiries regarding fiscal matters to: 

Ms. Linda Whipp
Grants and Contracts Management Office
National Institute on Aging
7201 Wisconsin Avenue, Suite 2N212, MSC 9205
Bethesda, MD  20892
Telephone:  (301) 496-1472
FAX:  (301) 402-3672


This program is described in the Catalog of Federal Domestic Assistance 
No. 93.866. Awards are made under authorization of sections 301 and 405 
of the Public Health Service Act as amended (42 USC 241 and 284) and 
administered under NIH grants policies and Federal Regulations 42 CFR 
52 and 45 CFR Parts 74 and 92. This program is not subject to the 
intergovernmental review requirements of Executive Order 12372 or 
Health Systems Agency review.
The PHS strongly encourages all grant and contract recipients to 
provide a smoke-free workplace and promote the non-use of all tobacco 
products.  In addition, Public Law 103-227, the Pro-Children Act of 
1994, prohibits smoking in certain facilities (or in some cases, any 
portion of a facility) in which regular or routine education, library, 
day care, health care or early childhood development services are 
provided to children.  This is consistent with the PHS mission to 
protect and advance the physical and mental health of the American 

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
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Bethesda, Maryland 20892
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