5-Hydroxymethyl furfural, Beta-Myrcene, Isoeugenol and Estragole, Pulegone,
and 2-Bis-Chloroethoxymethane

Release Date:  June 1, 1999

RFP NIH-ES-99-35  


National Institute of Environmental Health Sciences

The NIEHS is soliciting offers for a contract to evaluate the toxicologic
and carcinogenic potential of selected chemicals via oral administration.
This project includes 2-year studies of Formamide and 5-Hydroxymethyl
furfural; 90-day studies of isoeugenol and estragole and 2-year studies of
isoeugenol; 90-day and 2-year studies of Beta-myrcene; and 14-day, 90-day
and 2-year studies of Pulegone and 2-Bis-Chloroethoxymethane.  Multiple
studies shall be conducted concurrently.  The base contract shall consist of
Phase 1 for all seven chemicals to include those work activities associated
with the determination of bulk chemical purity and identity, and validation
of dose formulation/analysis methods, and any health and safety concerns.
Upon successful completion of Phase 1, the Government may unilaterally
exercise options for the conduct of 14-day, 90-day, or 2-year studies
specified as Phases 2 through 4.  These studies shall be conducted according
to the Specifications for the Conduct of Studies to Evaluate the Toxic and
Carcinogenic Potential of Chemical, Biological and Physical Agents in
Laboratory Animals for the National Toxicology Program dated August, 1992,
with subsequent revisions.  Offerors shall have a working laboratory
involved in conducting studies by oral administration  in place by the date
of proposal submission.  The Principal Investigator, Toxicologist, Chemist,
Health and Safety Officer and Quality Assurance Unit Officer shall be
employees of the contract laboratory (i.e., not consultants or
subcontractors).  The daily interaction and constant coordination of efforts
needed amongst these discipline areas throughout the in-life portion of the
studies makes it critical that they be physically and organizationally
together.  Award of one cost-reimbursement, completion type contract on
March 31, 2000 on an open competition basis is contemplated as a result of
this solicitation.  The estimated level of effort is 2,170 labor hours for
the base contract and 174,450 labor hours for all options.  The estimated
period of performance is approximately nine and one-half months for the base
contract and four years ten months if all options are exercised.  Interested
organizations should request either a streamlined or full RFP package.  If
no selection is made, a streamlined version of the RFP will be provided,
which will include only the Statement of Work, deliverables and reporting
requirements, special requirements, mandatory qualifications, and technical
evaluation criteria.  After examination of these documents, any organization
interested in responding to this RFP must request the entire RFP by written,
telephonic ((919) 541-0416), or telefax request ((919) 541-2712).  The
electronic version of the CBD synopsis and the RFP (which will be available
on or about June 18, 1999 without the NTP specifications) will be available
on the Internet at:   All
responsible sources may submit a proposal which shall be considered by the
Agency.  Expected release date of the RFP is June 18, 1999 with proposals
due August 17, 1999.

Requests should reference RFP NIH-ES-99-35 and should be forwarded to:

National Institute of Environmental Health Sciences
Research Contracts Branch, DERT
ATTN:  Marilyn B. Whaley, Contract Specialist
79 T.W. Alexander Drive, 4401 Building
P. O. Box 12874
Research Triangle Park, NC  27709
(919) 541-0416 (Telephone)
(919) 541-2712 (Fax)

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