EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN-VITRO TECHNIQUES

Release Date:  April 20, 1999

RFP AVAILABLE:  N01-CN-85093-63

P.T.

National Cancer Institute

The Chemoprevention Branch of the Division of Cancer Prevention (DCP) National
Cancer Institute (NCI), National Institutes of Health (NIH), is expanding the
existing Master Agreement Pool for Evaluation of Chemopreventive Agents by In-
Vitro Techniques.  Screen and evaluate the activity of chemopreventive agents in
various in vitro assays relating to the inhibition of cell transformation. Agents
with potential chemopreventive activity are identified by epidemiologic surveys,
initial laboratory (experimental) findings, observations in the clinical setting,
or structural homology with agents having known chemopreventive activity.  A
rigorous and systematic evaluation of these candidate agents is necessary before
their efficacy can be examined in clinical trials for cancer prevention.  In
vitro screening and evaluation techniques measuring the ability of these
chemopreventive agents to inhibit transformation provides a relatively rapid and
efficient means of qualifying these agents for further evaluation for the
prevention of cancer in humans.  Recent progress in the in vitro systems has led
to the development of cell culture models and techniques, which make possible an
evaluation of the effects of various substances on cell transformation.

Master Agreements will be awarded to all respondents whose technical proposal is
considered acceptable.  The Master Agreement award is non-monetary and is
exclusively for the purpose of compiling a pool of contractors who are pre-
qualified to perform services to perform Evaluation of Chemopreventive Agents by
In-Vitro Techniques.  Master Agreement holders receiving a contract award will
be selected through this pool, based on technical merit and on budgetary
considerations for specific workstatements.  Any MA awarded as a result of this
solicitation will be in effect from the effective date to October 30, 2002.  This
solicitation will be open for the duration of the existing MA pool with due dates
for receipt of proposals semi-annually, August 1 and February 1 (or the next
business day) of each year.  All responsible sources meeting these criteria are
encouraged to submit a proposal and a sample requirement to be considered by the
NCI.  ALL MASTER AGREEMENT HOLDERS ALREADY IN THE EXISTING MASTER AGREEMENT POOL
NEED NOT RESPOND TO THIS ANNOUNCEMENT.

The RFP may be accessed through the Research Contracts Branch Home Page at the
following URL:  http://www.peacetech.com/rcab/rfps_published.asp

It is the offerors responsibility to monitor the above Internet site for the
release of this solicitation and amendments, if any. POTENTIAL OFFERORS WILL BE
RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS.

INQUIRIES

All requests should reference the RFP No. N01-CN-85093-63.  No collect calls will
be accepted.  Numbered Note 26 - Based upon market research, the Government is
not using the policies contained in Part 12, Acquisition of Commercial Items, in
its solicitation for the described supplies or services.  However, interested
persons may identify to the contracting officer their interest and capability to
satisfy the Government's requirement with a commercial item within 15 days of
this notice.

Tina M. Huyck
Research Contracts Acquisition Branch
National Cancer Institute
6120 Executive Boulevard, Room 635
Rockville, MD  20852
Telephone:  (301) 435-3830
FAX:  (301) 402-8579
Email:  th38q@nih.gov

Elaine M. Hochman
Research Contracts Acquisition Branch
National Cancer Institute
6120 Executive Boulevard, Room 635, MSC 7226
Rockville  MD  20852-7226
Telephone:  (301) 435-3836
FAX:  (301) 402-8579
Email:  eh28f@nih.gov

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