Release Date:  February 19, 1999


National Cancer Institute

The purpose of the Network is to establish a scientific consortium of
investigators, academic as well as industrial, with resources for basic,
translational, and clinical research.  The consortium will have three main
components -- Biomarkers Developmental Laboratories, Biomarkers Validation
Laboratories and Clinical/Epidemiologic Centers.  The Biomarkers Developmental
Laboratories will have responsibility for the development and characterization
of new or refinement of existing biomarkers; the Biomarkers Validation
Laboratories will serve as a Network resource for clinical and laboratory
validation of biomarkers, which include technological development and
refinement; and the Clinical/Epidemiology Centers will conduct clinical and
epidemiological research regarding the clinical application of biomarkers.

Request for Applications (RFA) CA-98-028 is for the Biomarkers Developmental
Laboratories component of the Network.  The complete text of the RFA is
available in the NIH Guide for Grants and Contracts at or can be
obtained through contacting the NCI staff member listed under INQUIRIES.  A
pre-application informational meeting for those investigators considering
submitting applications in response to the RFA will be held on Friday, March
12, 1999 from 1:00 p.m. to 4:00 p.m. at the Natcher Building, NIH, 45 Center
Drive, Bethesda, MD in the Conference Room D.

Representatives from the NCI Cancer Biomarkers Research Group, Grants
Administration Branch, and Special Review, Referral and Resources Branch will
be available to provide information and to answer questions  relevant to
applications responding to this RFA.  Transcripts will be available upon
request for investigators who are unable to attend.


Investigators who plan to attend should contact the NCI staff member listed
below by March 5, 1999 to confirm their attendance and to obtain further

For further information, and to confirm attendance, contact:

Sudhir Srivastava, Ph.D., M.P.H.
Division of Cancer Prevention
National Cancer Institute
6130 Executive Boulevard, Room 330, MSC 7346
Bethesda, MD  20892-7388
Telephone:  (301) 496-3983
FAX:  (301) 402-0816

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