CENTERS FOR GENOMIC APPLICATIONS TO HEART, LUNG, AND BLOOD RESEARCH Release Date: November 27, 1998 P.T. National Heart, Lung, and Blood Institute INTRODUCTION The National Heart, Lung, and Blood Institute (NHLBI) announces its intentions to establish Centers for Genomic Applications (CGA) to Heart, Lung, and Blood Research. The purpose of this announcement is (1) to provide potential applicants time to discuss ideas and to begin to form links for developing applications and (2) to request comments from the scientific community regarding scientific areas, structure, and organization of these Centers that would serve the needs of heart, lung, and blood researchers. PURPOSE AND CHARACTERISTICS OF A CGA Recognizing that expertise and technologies in selected critical areas are not necessarily located at a single institution or even within a particular region, the NHLBI is seeking to establish research centers, whose components may be located at different geographical sites, contributing to the NHLBI Functional Genomics Program. A working definition of the term "functional genomics" would be the interpretation of genomic sequence or gene expression on a genomic scale to elucidate function (biological insights). The principal goal of a Center would be to extract or generate biologically useful information on a genomic scale that is of relevance to heart, lung, and blood researchers. A CGA would use and/or generate genomic information and/or high through-put technologies to conduct innovative research, provide a genomic interface that will contribute to the heart, lung, and blood research communities (i.e., technologies or databases that are made accessible and utilized by heart, lung and blood biologists), train new investigators in this emerging discipline, and contribute biological information of use to, and extending beyond the realm of, heart, lung, and blood research. Each CGA will involve a highly interactive group of investigators constituting a critical mass and blend of diverse expertise and talent (e.g., automation processing technology, genomics, physiology, pathology, bioinformatics, pharmacology, biochemistry, cellular and molecular biology, engineering, clinical medicine) and provide a platform to import enabling high through-put technologies, sustain them, apply them to critical questions, and/or develop and import new technologies to replace outdated ones. In addition, a hallmark feature of these Centers will be their ability to respond rapidly and flexibly to scientific advances in a diverse array of disciplines. Examples of a few of the possible themes for Centers include: (A) Centers for genome wide expression analysis of conditions/tissues relevant to heart, lung, and blood research. (B) Centers for high through-put resequencing of genes from patient populations relevant to heart, lung, and blood researchers. (C) Model organism (zebrafish, worm, mouse, rat, etc.) mutagenesis centers focused on the generation of new reagents relevant to heart, lung, and blood research. Additionally, the Center would serve as a location for NHLBI investigators to carry out targeted experiments as well as serve as a training Center. The Centers would have the capacity to develop and apply informatic analysis to the data generated and make this information available to the public as well as provide computational know-how so that the heart, lung, and blood user communities could generate and analyze their own data linked to the Center. Although the components of a given CGA need not share a common location, each CGA should possess the following attributes: Research Focus -- a common research theme or focus. Core Resources -- core resources that are essential for the accomplishment of its research objectives. Bioinformatics -- expertise related to the effective capture, integration, use, and dissemination of information resources expected to be developed by the center. Commitment to Share -- cooperate with and/or to make available to other investigators resources, technologies and data bases developed by the CGA. (A model for this aspect of the center, somewhat distinct from a traditional NIH research center, would be the access that the community has had to mapping and sequence data coming from the Human Genome Program.) Training -- opportunities for training in the development and use of resources created by the center to both newly trained scientists and to established investigators interested in gaining new skills. Technology -- develop, import, and utilize critical, modern technologies. Duration -- maintain the relationship among projects, core resources, and sharing with the broader scientific community for a planned extended award period of 7 years. TIME TO PREPARE APPLICATIONS Investigators who may wish to establish a Center for Genomic Applications to Heart, Lung, and Blood Research are strongly encouraged to begin discussions with colleagues, forge links with collaborators (non-profit and for-profit), and begin to develop a theme and a strategy for preparing an application. PROVIDE YOUR COMMENTS The NHLBI requests that members of the scientific community provide comments regarding areas of investigation, structure, and organization of these Centers that would serve the needs of heart, lung, and blood researchers. Of particular interest are research themes, enabling technologies to be used, and information and materials that would be made available to investigators outside the Centers. Submitted information will help to define the scope of a Request for Applications (RFA) that will be issued in early 1999. As these Centers will require collaboration of investigators from many disciplines, some of which are not traditionally involved in heart, lung, and blood research, responses are welcome from a broad range of areas of expertise. This notice is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the Government to issue a Request for Applications or award a grant. Do not include proprietary information. The Government does not intend to award a grant on the basis of responses nor otherwise pay for the preparation of any information submitted or the Government's use of such information. Acknowledgment of receipt of responses will not be made, nor will respondents be notified of the Government's evaluation of the information received. However, should such a requirement materialize, no basis for claims against the Government shall arise as a result of a response to this notice or the Government's use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. Text should be limited to no more than three pages. Responses should be clearly identified with "Centers for Genomic Applications to Heart, Lung, and Blood Diseases," provide contact information for the author(s), and are due no later than December 30, 1998. Submit one copy of your response to: Ms. Chris Davis Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute 6701 Rockledge Drive, Room 9170, MSC 7940 Bethesda, MD 20892-7940 Bethesda, MD 20817 (for express/courier service Telephone: (301) 435-0477 FAX: (301) 480-1336 Email: davisca@gwgate.nhlbi.nih.gov
Return to NIH Guide Main Index
Office of Extramural Research (OER) |
National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892 |
Department of Health and Human Services (HHS) |
||||||||
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files. |