FINDINGS OF SCIENTIFIC MISCONDUCT

Release Date:  May 11, 1998

P.T.

Department of Health and Human Services

Notice is hereby given that the Office of Research Integrity (ORI)
has made a final finding of scientific misconduct in the following
cases:

Cynthia King, Bienville Medical Group:  Based on an investigation
conducted by ORI's Division of Research Investigations, ORI found
that Ms. King, staff assistant, Bienville Medical Group, engaged in
scientific misconduct in clinical research conducted as part of a
multicenter clinical trial supported by a National Heart, Lung, and
Blood Institute (NHLBI), National Institutes of Health (NIH)
contract.  Ms. King falsified and/or fabricated data and
information collected from patients for the Antihypertensive and
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) at
the clinical site in Terry, Mississippi.  ORI acknowledges Ms.
King's cooperation and assistance in completing its investigation.

Ms. King has accepted the ORI finding and has entered into an
Agreement with ORI in which she has voluntarily agreed, for the
three year period beginning April 6, 1998:

(1) to exclude herself from serving in any advisory capacity to the
Public Health Service (PHS), including but not limited to service
on any PHS advisory committee, board, and/or peer review committee,
or as a consultant; and

(2) that any institution that submits an application for PHS
support for a research project on which Ms. King's participation is
proposed or which uses her in any capacity on PHS supported
research or that submits a report of PHS-funded research in which
she is involved must concurrently submit a plan for supervision of
her duties to the funding agency for approval.  The supervisory
plan must be designed to ensure the scientific integrity of Ms.
King's research contribution.  The institution also must submit a
copy of the supervisory plan to ORI.

No scientific publications were required to be corrected as part of
this Agreement.


Patrina Lowe, Bienville Medical Group:  Based on an investigation
conducted by ORI's Division of Research Investigations, ORI found
that Ms. Lowe, former staff member, Bienville Medical Group,
engaged in scientific misconduct in clinical research conducted as
part of a multicenter clinical trial supported by a National Heart,
Lung, and Blood Institute (NHLBI), National Institutes of Health
(NIH) contract.  Ms. Lowe falsified and/or fabricated data and
information collected from patients for the Antihypertensive and
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) at
the clinical site in Terry, Mississippi.  ORI acknowledges Ms.
Lowe's cooperation and assistance in completing its investigation.

Ms. Lowe has accepted the ORI finding and has entered into an
Agreement with ORI in which she has voluntarily agreed, for the
three year period beginning April 6, 1998:

(1) to exclude herself from serving in any advisory capacity to the
Public Health Service (PHS), including but not limited to service
on any PHS advisory committee, board, and/or peer review committee,
or as a consultant; and

(2) that any institution that submits an application for PHS
support for a research project on which Ms. Lowe's participation is
proposed or which uses her in any capacity on PHS supported
research or that submits a report of PHS-funded research in which
she is involved must concurrently submit a plan for supervision of
her duties to the funding agency for approval.  The supervisory
plan must be designed to ensure the scientific integrity of Ms.
Lowe's research contribution.  The institution also must submit a
copy of the supervisory plan to ORI.

No scientific publications were required to be corrected as part of
this Agreement.

INQUIRIES

For further information contact:

Acting Director
Division of Research Investigations
Office of Research Integrity
5515 Security Lane, Suite 700
Rockville, MD 20852
Telephone:  (301) 443-5330

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