EFFECTIVENESS OF TREATMENT FOR ADOLESCENTS WITH MAJOR DEPRESSION Release Date: April 28, 1998 RFP AVAILABLE: NIMH-98-DS-0008 P.T. National Institute of Mental Health The National Institute of Mental Health (NIMH) is issuing a Request for Proposals (RFP) entitled "Effectiveness of Treatment for Adolescents with Major Depression" as Full and Open Competition under SIC Code 8093. The NIMH plans to award a five year cost-reimbursement contract, and plans to make the award by September 30, 1998. This will be the initial award for this requirement. The purpose of this contract is to launch a clinical trial, with adequate statistical power to address a number of research questions related to the Treatment of Depression in Adolescents. In order to acquire the necessary sample size (estimated to be in the order of 350-500 adolescents) and ensure adequate representation of adolescents, it is estimated that 5 to 10 sites will be needed. The actual proposed sample size must be adequately supported and convincingly justified by a complete power analysis calculation. This project will involve a multi-center effort and a collaborative relationship between the coordinating center, clinical site investigators, and NIMH staff. The main organizational components will be: 1) the Coordinating Center; 2) the study Steering Committee, formed by the Principal Investigators of the clinical sites, the Contractor (Coordinating Center), the GPO, and other NIMH representatives, as designated by the GPO; 3) the study Scientific Advisory Group, consisting of independent advisors to provide consultation on the scientific aspects of the study; 4) the Publication Committee charged to coordinate the preparation of publishable reports; and 5) the NIMH Data Safety and Monitoring Board (or DSMB), consisting of independent experts in clinical trials and charged with reviewing the safety and progress of the study. RFP No. NIMH-98-DS-0008 will be available on or about April 22, 1998 and the receipt date for proposals is June 10, 1998. The RFP may be accessed through the NIMH Home Page by using the following instructions: access the home page at http://www.nimh.nih.gov, first select "Grants and Contracts," then select "NIMH Request for Proposals (RFP)", and lastly select "NIMH-98-DS-0008." Please note that the RFP for this requirement will include the Statement of Work, Deliverables and Reporting Requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and initial review process, offerors comprising of the competitive range will be requested to provide additional documentation to the Contracting Officer. All responsible sources may submit a proposal that will be considered by the NIMH. This advertisement does not commit the Government to award a contract. INQUIRIES Inquiries may be directed to: David J. Eskenazi Contracts Management Branch National Institute of Mental Health 5600 Fishers Lane, Room 9C-15 Rockville, MD 20857-8030 Telephone: (301) 443-2696 Email: de5d@nih.gov
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