Release Date:  April 3, 1998



National Institute of Mental Health

The National Institute of Mental Health proposes to issue a solicitation (RFP)
No. NIMH-98-DB-0004 entitled "NIMH Genetics Coordinating Center" as Full and Open
Competition under SIC Code 8731.

The purpose of this requirement is to receive and process data and biological
materials collected from individuals with serious brain disorders and their
relatives.  These data and biological materials shall be added to those currently
distributed under the NIMH Human Genetics Initiative.  Cell lines, DNA, and
electronic files suitable for immediate genetic analysis will be prepared.  Given
that this is a highly technical endeavor, the offeror shall demonstrate prior
experience in preparing pedigree files and using those files to conduct
statistical genetic analyses.  This shall furthermore be documented by
publications in peer-reviewed scientific journals.  This contractor shall also
widely distribute this information, for use exclusively in genetic research on
serious brain disorders, to qualified investigators in the scientific community
(including scientists in industry, the NIH intramural program, and public and
private universities) granted access by NIMH.

Specifically, the following tasks shall be performed on data and biological
materials received from projects supported under both RFA MH-98-010 and a second
one to be issued in FY 1999: receive blood samples collected from patients and
their relatives and create cell lines via Epstein-Barr virus transformation of
lymphocytes from these blood samples, for a fixed price; expand these
lymphoblastoid cell lines to extract DNA samples, for a fixed price; receive
clinical, diagnostic, pedigree structure, and other data, for incorporation into
phenotypic databases that are suitable for immediate genetic analysis; receive
data obtained from any and all genetic analyses of these materials, for
incorporation into genotypic databases; maintain, store, and distribute all
databases, cell lines, and DNA samples for immediate genetic analysis by
qualified investigators granted access by NIMH to these data and materials; and
continue to distribute data and biological materials already collected under the
NIMH Human Genetics Initiative.

The NIMH plans to award a five year (including option years) reimbursement
contract, and plans to make the award by September 30, 1998.  This will be the
initial award for this requirement.

Request for Proposal (RFP) No. NIMH-98-DB-0004 will only be available
electronically on or about March 31, 1998 and the receipt date of proposal on or
about June 1, 1998. The RFP may be accessed through the NIMH Home Page by using
the following instructions: access the home page at,
first select "Grants and Contracts", then select "NIMH Request for Proposals
(RFP)", and lastly select "NIMH-98-DB-0004."

Please note that the RFP for this requirement will include the Statement of Work,
Deliverables and Reporting Requirements, the Technical Evaluation Criteria, and
proposal preparation instructions. All information required for the submission
of an offer will be contained in the electronic RFP package. Following proposal
submission and initial review process, offerors comprising of the competitive
range will be requested to provide additional documentation to the Contracting
Officer. All responsible sources may submit a proposal that will be considered
by the NIMH. This advertisement does not commit the Government to award a


Inquiries may be directed to:

Patricia L. Gibbons
Contracts Management Branch
National Institute of Mental Health
5600 Fishers Lane, Room 9C-15
Rockville, MD  20857-8030
Telephone:  (301) 443-2696

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