NIH GUIDE, Volume 26, Number 1, January 10, 1997


P.T. 34



  Biological Resources 


National Cancer Institute


The National Cancer Institute's Cooperative Human Tissue Network

(CHTN) provides human tissue for biomedical research.  The CHTN

provides normal, benign, pre-cancer and cancer tissue.  Trained

personnel coordinate the retrieval, preservation and delivery of

specimens from surgical resection and autopsy.  During nine years of

operation, the CHTN has supplied more than 100,000 specimens to

approximately 600 investigators.  Human tissue provided by the CHTN

has been utilized for a variety of research projects, such as studies

of  gene isolation, gene deletion, gene mutation, growth factors,

isoenzymes, subcellular organelles, flow cytometry, DNA hybridization

and the development of monoclonal antibodies and cell lines.  Five

member institutions coordinate the collection and distribution of

tissues in the US and Canada.  Collection, storage and distribution

requirements vary with the research approach and tissue type.

Studies on M-RNA and labile proteins require snap-frozen surgical

tissue stored at ultra-low temperatures.  More stable biological

molecules allow a wide range of studies on autopsy tissue, including

establishing viable tissue cultures and cell lines.  Investigators

should discuss the tissue requirements for their research, to assure

the largest number and range of research specimens.  In order for the

CHTN to collect and provide quality tissue specimens to meet specific

user needs, each investigator is required to complete a detailed

tissue request form.  This include information about the type and

amount of tissue required, tissue preparation, storage, and shipment

requirements (e.g., media, snap frozen, sterile).  The CHTN makes

every effort to tailor collection, storage and shipment to the needs

of the investigator.  Tissue is provided according to the following

priority order:


1.  Funded, peer-reviewed investigators, including those from Federal

and National laboratories.

2.  New investigators and academic investigators developing new

research projects.

3.  Other investigators.


A nominal processing fee of $20 per specimen is charged to cover some

of the cost of collecting, preparing, and handling the tissue.  In

addition, the investigator is responsible for the cost of shipping

specimens to his/her laboratory.  Application forms will soon be

available from the CHTN Internet site at: Applications are also

available from the division that serves your geographical area:


EASTERN DIVISION - The Eastern Division covers the northeast, the

area bounded by the western border of Pennsylvania, and the southern

border of Maryland and Alaska and Hawaii.


University of Pennsylvania Medical Center

Philadelphia, PA  19104-4283

Telephone:  (215) 662-4570

FAX:  215-614-6554



MIDWESTERN DIVISION - The Midwestern Division extends from West

Virginia and states west of Pennsylvania north to Minnesota and south

through Missouri and Canada.


The Ohio State University

Columbus, OH  43210

Contact:  Ms. Carolyn Cordial

Telephone:  (614) 293-5493

FAX:  (614) 293-5851



PEDIATRIC DIVISION - The Pediatric Division operates nationwide.


Children's Hospital

Columbus, OH  43205

Contact:  Ms. Nancy Sachs

Telephone:  (614) 722-2890

FAX:  (614) 722-2897



SOUTHERN DIVISION -  The Southern Division encompasses Kentucky and

Virginia and all states south and west of the Carolinas to Texas.


University of Alabama at Birmingham

Birmingham, AL  35294-0007

Contact:  Ms. Katherine Sexton

Telephone:  (205) 934-6071

FAX:  (205) 934-0816



WESTERN DIVISION - The Western Division includes the states north of

Oklahoma and west of Texas.


Case Western Reserve University

Cleveland, OH  44106

Contact:  Ms. Diane Zorkle

Telephone:  (216) 844-8538

FAX:  (216) 844-8522




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