FINDINGS OF SCIENTIFIC MISCONDUCT 

NIH GUIDE, Volume 26, Number 27, August 15, 1997

 

P.T. 34



Keywords:

  Ethics/Values in Science & Technol 

  Grants Administration/Policy+ 

 

Department of Health and Human Services

 

Notice is hereby given that the Office of Research Integrity (ORI)

has made a final finding of scientific misconduct in the following

case:

 

David N. Shapiro, M.D., St. Jude Children~s Research Hospital:  Based

upon a report from St. Jude Children~s Research Hospital as well as

information obtained by the Office of Research Integrity (ORI) during

its oversight review, ORI found that Dr. Shapiro, former faculty

member, St. Jude Children~s Research Hospital, engaged in scientific

misconduct by falsifying the authorship of five publications listed

in his biographical sketches in several National Institutes of Health

(NIH) grant applications, including applications submitted to the

National Institute of Arthritis and Musculoskeletal and Skin Diseases

(NIAMS), the National Institute of General Medical Sciences (NIGMS),

the National Institute of Diabetes and Digestive and Kidney Diseases

(NIDDK), and the National Cancer Institute (NCI).

 

Specifically, Dr. Shapiro listed himself as an author when he was

not.  Dr. Shapiro also fabricated data for Figures 5 and 7 in the

following publication:  Sublett, J.E., Jeon, I.S., & Shapiro, D.N.

~The aveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a

transcriptional activator.~  Oncogene 11:545-552, 1995.  Dr. Shapiro

has submitted a letter to Oncogene requesting retraction of these

figures.

 

Dr. Shapiro has accepted the ORI finding and has entered into a

Voluntary Exclusion Agreement with ORI in which he has voluntarily

agreed:

 

(1) to exclude himself from serving in any advisory capacity to the

Public Health Service (PHS), including but not limited to service on

any PHS advisory committee, board, and/or peer review committee, or

*as a consultant for a period of three years, beginning on July 29,

1997;

 

(2) to exclude himself from any contracting or subcontracting with

any agency of the United States Government and from eligibility for,

or involvement in, nonprocurement transactions (e.g., grants and

cooperative agreements) of the United States Government as defined in

45 C.F.R. Part 76 (Debarment Regulations) for a period of two years,

beginning on July 29, 1997;

 

(3) that any institution that submits an application for PHS support

for a research project on which Dr. Shapiro~s participation is

proposed or that uses him in any capacity on PHS supported research

must concurrently submit a plan for supervision of his duties to the

funding agency for approval for a period of one (1) year following

the two year exclusion.  The supervisory plan must be designed to

ensure the scientific integrity of Dr. Shapiro~s research

contribution.  The institution also must submit a copy of the

supervisory plan to ORI.

 

INQUIRIES

 

For further information contact:

 

Acting Director, Division of Research Investigations

Office of Research Integrity

5515 Security Lane, Suite 700

Rockville, MD  20852

Telephone:  (301) 443-5330

 

.

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