NIH GUIDE, Volume 26, Number 10, March 28, 1997




P.T. 34


  Drugs/Drug Abuse 


  Chemical Synthesis 




National Institute on Drug Abuse


The National Institute on Drug Abuse (NIDA) is soliciting proposals

from qualified organizations having the capability to design and

synthesize compounds which affect primarily dopaminergic systems and

either substitute for cocaine or antagonize its effects.  The project

shall involve the synthesis of any of the following: dopamine uptake

inhibitors with a slower rate of onset than cocaine; compounds which

affect dopaminergic systems through the inhibition of dopamine or

serotonin transporters;  serotonin transporter selective cocaine

analogs;  dopamine partial agonists, agonists, and antagonists;  and

dopamine sparing cocaine antagonists (compounds that bind to the

dopamine transporter without inhibiting dopamine uptake); and

compounds selective for D1 and D3 receptors.  The project shall also

provide for the scale-up production, and analog synthesis, of

promising compounds.  The major goal of this project is to provide

NIDA with a resource of novel compounds with potential use in the

treatment of cocaine abuse.  It is anticipated that six cost

reimbursement, term type contracts will be awarded for a period of

two years, with two one-year options.  This requirement is a partial

set-aside for small business, i.e., three of the awards will be made

to small businesses.


RFP No. N01DA-7-8077 will be available electronically on or about

April 14, 1997, and may be accessed through the NIH Gopher and/or the

Internet by using the following electronic mail addresses and



1.  NIH Home Page (via the World Wide Web): Access the NIH Home Page

by using . Once you are at the NIH Home Page,

select "Grants and Contracts"; select NIH Gopher directory: listed

under the "Contracts Page" section.  Once at the NIH R&D Gopher,

select "RFPs Available"; select "NIDA"; and select "RFP N01DA-7-

8077".  (URL: gopher://


2.  NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV Port 70

(you should now be in the NIH Gopher).  Select "Grant and Research

Information"; select "R&D Request for Proposals (RFP)"; select "RFPs

Available"; select "NIDA"; and, select "RFP N01DA-7-8077".


Please note that the RFP for this acquisition will be streamlined to

include only the Work Statement, deliverable and reporting

requirements, special requirements and mandatory qualifications,

Technical Evaluation Criteria, and proposal preparation instructions.

All information required for the submission of an offer will be

contained in the electronic RFP package.  Response to this RFP will

be due on or about May 29, 1997.  Any responsible offeror may submit

a proposal which will be considered by the Government.  This

advertisement does not commit the Government to award a contract.




Kenneth E. Goodling

Contracts Management Branch

National Institute on Drug Abuse

5600 Fishers Lane, Room 10-49

Rockville, MD  20857

Telephone:  (301) 443-6677

FAX:  (301) 443-7595




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