NIH GUIDE, Volume 25, Number 34, October 11, 1996




P.T. 34



  Veterinary Medicine 


National Cancer Institute


The National Cancer Institute (NCI), Division of Cancer Treatment,

Diagnosis and Centers (DCTDC), Development Therapeutics Program (DTP)

anticipates the award of one cost-reimbursement contract, for a five

year period, beginning on or about July 30, 1997.  As a minimum

requirement, the contractors must comply with the FDA's current Good

Laboratory Practice Regulations (GLPs).  The proposed awarded

contract will be administrated on a work assignment managed basis.

Work assignments will be issued under the proposed, level of effort,

contract resulting from this solicitation.  DTP is seeking

organizations to perform a variety of pathology and veterinary

services to support the DTP preclinical toxicology and pharmacology

program for anticancer and anti-AIDS drug development.  The

organization should have the facilities and staff to carry out the

requested efforts and the management expertise to respond to the

diverse and changing needs of this project.  Specifically, the work

assignments to be issued will involve the following:  operation of an

repository to hold the pathology materials and raw data generated in

past and future toxicology studies; storage of data on optical

medium; performance of an independent verification (peer review) of

the pathological findings by the study pathologist especially with

respect to individual diagnoses, drug-relatedness, nomenclature and

slide quality; provide a pathology support program to prepare blocks

and slides and conduct histopathological evaluation of tissues;

perform the site visits to conduct necropsies, slide preparation or

to assist the Project Officer in project evaluation.  This includes

providing expertise in special techniques to assess cardiotoxicity,

neurotoxicity, nephrotoxicity, etc.; storage, maintenance and

shipment of Government infusion equipment to other DTP contractors;

development and implementation of a new surgical or other procedures

for drug administration or sampling; instruction in these procedures;

or performance of these procedures in actual animal studies; conduct

site visits to the DTP toxicology contractor laboratories to evaluate

pathology laboratories, animal care programs or to investigate

pathology or animal care problems; and to support the Toxicology and

Pharmacology Branch toxicology efforts required through the

preparation of study protocols, study monitoring and report

evaluation.  The Principal Investigator should be a board certified

veterinary pathologist or veterinarian with at least three years

experience with similar programs.  This is recompetition of a

contract performing these activities.




The Request for Proposal will be available on or about October 3,

1996.  No collect calls will be accepted.  Requests for the RFP may

be directed to:


Elsa B. Carlton

Research Contracts Branch

National Cancer Institute

6120 Executive Boulevard, Room 603 - MSC 7220

Bethesda, MD  20892-7220

Telephone:  (301) 496-8620



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