NIH Guide, Volume 25, Number 20, June 21, 1996




P.T. 34





National Institute of Environmental Health Sciences


The purpose of this project is to conduct chemical disposition

studies in mammals to support the bioassay program of the National

Toxicology Program (NTP).  The general objective of this project is

to procure detailed chemical disposition data from a number of

studies (approximately three to five annually) of selected

environmental contaminants or model compounds in laboratory rats

(Fischer 344) and or mice (B6C3F1).  Most studies will address the

disposition of organic chemicals or environmental contaminants;

however, studies of inorganic compounds may also be requested.  One

or more additional studies per year may investigate the comparative

metabolism of chemicals in human and rat liver slices in vitro.

Individual studies may vary in complexity from preliminary

investigations of chemical absorption to detailed studies of all

phases of chemical disposition, toxicokinetics, and metabolism.


The immediate goal of these studies is to determine more accurately

the doses for NTP bioassay studies.  The long-range goal is the

accumulation of data that will permit a better assessment of

structure-activity relationships chemical absorption, metabolism and

disposition in laboratory animals and to better compare metabolic

pathways in laboratory animals and humans.  Award of up to two cost

reimbursement, term form, level of effort type contracts with a

period of performance of five years are contemplated as a result of

this solicitation.  The Government estimates approximately 1.75

professional and 2.75 technical for a total of 4.5 person years per

year for each contract award.




Interested organizations may request either a streamlined or full RFP

package.  If no selection is made, a streamlined version of the RFP,

which includes only the Statement of Work, deliverables and reporting

requirements, special requirements, and technical evaluation

criteria, will be provided.  After examination of these documents,

any organization interested in responding to this RFP must request

the entire RFP in writing or by FAX request.  The electronic version

of the synopsis and the RFP (which will be available on or about June

21, 1996) are available on the world wide web at: or Gopher://

All responsible sources may submit a proposal that will be considered

by the Agency.  Expected release date of the RFP is June 21, 1996

with proposals due on August 21, 1996.  Requests for the solicitation

must reference RFP No. NIH-ES-96-35 and be

directed to:


Marilyn B. Whaley

Contracts and Procurement Management Branch, OM

National Institute of Environmental Health Sciences

79 T.W. Alexander Drive, 4401 Building

P.O. Box 12874

Research Triangle Park, NC  27709

FAX:  (919) 541-2712



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