NIH GUIDE, Volume 25, Number 20, June 21, 1996




P.T. 34


  Dosage Forms+ 

  Chemotherapeutic Agents 




National Cancer Institute


The pharmaceutical Resources Branch of the Developmental Therapeutics

Program, Division of Cancer Treatment, Diagnosis, and Centers,

National Cancer Institute (NCI) is seeking contractors to develop

acceptable dosage forms for compounds to be subsequently evaluated in

cancer and HIV patients and to carry out innovative studies leading

to more effective approaches for the intravenous delivery of

compounds that possess limited solubility and/or stability.  NCI will

select and provide the compounds to be studied.  In addition to

solubility problems, the projects will require considerable

analytical work, particularly the development of a

stability-indicating assay to monitor the integrity of the parent

compound during the formulation studies.  These investigations will

be directed toward a pharmaceutical dosage form that will meet

certain solubility and stability targets determined by the

Government.  The Principal Investigator on this project should

possess a Ph.D. in Pharmaceutics or Medicinal Chemistry and should

also have at least three years experience in the development of

injectable formulations.  It is anticipated that three

cost-reimbursement terms type contracts will be awarded for a base

period of three years, with two one year options for each contract.

The proposed contract project represents a recompetition of Contracts

N01-CM-27755 (University of Kansas), N01-CM-27756 (University of

North Carolina), N01-CM-27757, (University of Arizona), and

N01-CM-27720 (University of Utah).




Request for Proposals (RFP) NCI-CM-77017-28 will be available to all

interested offerors on or about June 24, 1996, with a response date

of August 26, 1996, for the receipt of proposals.  A copy of RFP No.

NCI-CM-77017-28 can be obtained by written or FAX request to:


Ms. Carolyn Barker

Research Contracts Branch

National Cancer Institute

Executive Plaza South, Room 603

6120 Executive Boulevard - MSC 7220

Bethesda, MD  20892-7220


FAX:  (301) 402-6699



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