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NIH GUIDE, Volume 25, Number 10, March 29, 1996




P.T. 34



  Infectious Diseases/Agents 


National Institute of Allergy and Infectious Diseases


The NIAID, DAIDS, has a requirement to quantitatively evaluate

therapeutic agents for efficacy against Cryptosporidium parvum

infection in a standardized, validated immunocompromised mouse model

test system.  In vivo studies will include evaluation of therapies in

combination in the primary mouse model; evaluation of therapies in a

validated, standardized animal model for hepatobiliary disease; and

evaluation of therapies using alternative strains of Cryptosporidium.

Therapeutic agents will be evaluated for efficacy in a standardized,

reproducible, and validated in vitro test system using intact

organisms.  The offeror should have available a primary mouse model

of Cryptosporidium infection and an in vitro system (including

relevant Cryptosporidium isolates) suitable for the evaluation of

therapies with potential for treatment of Cryptosporidium infections

in people with AIDS.


It is anticipated that one cost reimbursement, level-of-effort type

contract will be awarded for a period of five years beginning on or

about July 23, 1997.  It is estimated that 1,675% total effort will

be needed for this acquisition during the five-year period.


RFP NIH-NIAID-DAIDS-97-05 will be available electronically on or

about April 15, 1996, and may be accessed through either the NIH

Gopher or the NIH Home Page by using the following electronic mail

addresses and instructions:


1) To access the NIH Gopher: Point your gopher client to

GOPHER.NIH.GOV PORT 70.  (You should now be in the NIH Gopher.)

Select "Grant and Research Information," then select "R&D Request for

Proposals" (RFP).


2) NIH Home Page (via the World Wide Web):  Access the NIH Home Page

by using http://www.nih.gov.  Once you are at the NIH Home Page,

select "Grants and Contracts," then select "R&D Requests for

Proposals (RFP)."


Responses to this RFP will be due on August 15, 1996.  Any

responsible offeror may submit a proposal which will be considered by

the Government.  This advertisement does not commit the Government to

award a contract.




Inquiries regarding this RFP may be directed to:


Bruce E. Anderson

Contract Management Branch

National Institute of Allergy and Infectious Diseases

6003 Executive Boulevard, Room 3C-07 - MSC 7610

Bethesda, MD  20892-7610

Telephone:  (301) 496-8371

FAX:  (301) 402-0972

Email:  ba9i@nih.gov


No collect calls will be accepted.



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