NIH GUIDE, Volume 25, Number 9, March 22, 1996





  Grants Administration/Policy+ 


National Cancer Institute


As an experiment in reinvention of its extramural programs, the

National Cancer Institute (NCI) announces its intent, through the use

of solicited applicant responses and an accelerated executive review

(AER) exceptions process, to consider for funding meritorious

original unamended type 1 and type 2 research project grant (R01)

applications that receive a score that is within a defined percentile

zone near established grant pay lines.


Each fiscal year, the NCI intends to establish separate percentile

zones for:  (1) basic and (2) patient oriented research project

applications beyond the anticipated R01 payline that will be subject

to accelerated executive review by the NCI Executive Committee for

award as an exception.  This policy is subject to the availability of

sufficient funds and a sufficient number of applications of clear and

unambiguous merit in these categories.


The standard payline for percentiled R01 awards will be set based

upon a formula to be determined annually after a final budget has

been established for a fiscal year.  For FY 1996, a zone beyond the

payline has been established that equals approximately four

percentile points for basic science and 10 percentile points for

patient oriented R01 research applications.  NCI estimates that

approximately 130 unamended R01 applications might be within the

stated distances of the anticipated R01 pay line in FY 1996.  Thus,

this process potentially may result in award for up to 40 percent of

the anticipated eligible applications.


This paradigm is being adopted to expedite funding of high quality,

innovative research.  It is hoped that this program will

substantially raise the number of clinical research applications

submitted and funded.  For applications where peer review has

identified easily addressable concerns, it will avoid for many

investigators attendant delay (eight months for a full amendment) and

uncertainty of funding, and will lessen the burden on peer reviewers.

For clinical research applications, it will permit more timely and

effective use of unique cohorts and resources that often are

temporally unique assets.


Definition of Patient Oriented Research


Patient Oriented Research applications for these purposes will be

defined as follows:


Research conducted with human subjects and/or on material of human

origin such as tissues, specimens, and cognitive phenomena for which

an investigator or colleague directly interacts with human subjects.

This area of research includes: development of new technologies,

mechanisms of human disease, therapeutic interventions, clinical

trials, epidemiologic and biobehavioral studies, and outcomes and

health services research.




Accelerated executive review will apply to original (unamended)

submissions of competing type 1 and type 2 R01 applications. It will

not apply to applications submitted in response to RFAs.  R01

applications receiving only raw scores due to ad hoc review will be

assigned derived percentiles based on the average of the scores of

all R01 applications reviewed by the Division of Research Grants.




For specific questions on this process, applicants may contact the

NCI program director sending the original communication.  General

policy questions may be directed to:


Marvin R. Kalt, Ph.D.

Division of Extramural Activities

National Cancer Institute

6130 Executive Boulevard, Suite 600 EPN

Bethesda, MD  20892-7405




Return to 1996 Index

Return to NIH Guide Main Index

Office of Extramural Research (OER) - Home Page Office of Extramural
Research (OER)
  National Institutes of Health (NIH) - Home Page National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
  Department of Health and Human Services (HHS) - Home Page Department of Health
and Human Services (HHS) - Government Made Easy

Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files.