MEASUREMENT OF CAFFEINE, PARAXANTHINE, AND OSMOLALITY IN SERUM FROMTHE COLLABORATIVE PERINATAL PROJECT

 

NIH GUIDE, Volume 25, Number 7, March 8, 1996

 

RFP AVAILABLE:  NICHD-DESPR-96-07

 

P.T. 34, II



Keywords:

  0775013 

  Prenatal Factors 

 

National Institute of Child Health and Human Development

 

The National Institute of Child Health and Human Development (NICHD)

is seeking a laboratory to measure caffeine, paraxanthine, and

osmolality in serum from the Collaborative Perinatal Project (CPP).

One objective of this study is to determine if maternal caffeine and

paraxanthine levels, determined during the first or second trimester,

differ between women experiencing a spontaneous abortion and women

experiencing a live birth.  A second objective is to determine if

maternal caffeine and paraxanthine levels, determined early in the

third trimester, differ between women delivering small-for-dates and

appropriately-grown infants.  As approximately 45 percent of the CPP

women smoked, the study will also have good power to detect an

interaction between caffeine and tobacco.

 

This nested case-control study will use serum from the Collaborative

Perinatal Project.  695 women with fetal loss at <20 weeks' gestation

will be selected.  Each woman will be matched (for gestation at blood

drawing and study site) to four women who had a live birth of at

least 28 weeks' gestation.  Controls will also have

caffeine/paraxanthine measured in the first specimen drawn after 26

weeks to determine the association between third-trimester caffeine

intake and fetal growth retardation.  Therefore, a total of

approximately 6,300 serum samples will be analyzed.  In addition,

osmolality will be measured for each serum sample to determine the

degree of volume loss resulting from the extended period of storage.

 

INQUIRIES

 

This Request for Proposals (RFP) is a new solicitation.  The issuance

of this RFP will be on or about March 4, 1996 and proposals due by

4:00 P.M. (local time) on April 26, 1996.  All requests must cite RFP

No. NICHD-DESPR-96-07 and include two self-addressed mailing labels.

All sources who consider themselves qualified are encouraged to

submit a proposal.  This advertisement does not commit the Government

to made an award. Organizations desiring a copy of the RFP may send

their written or FAX request to:

 

Mrs. Lynn Salo

Contracts Management Branch

National Institute of Child Health and Human Development

6100 Executive Boulevard, Room 7A07 - MSC 7510

Bethesda, MD  20892-7510

FAX:  (301) 402-3676

 

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