CONSTRUCTION AND APPLICATION OF A FLOWCELL FOR ATTENUATED TOTAL 
REFLECTANCE-FOURIER-TRANSFORM INFRARED (ATR-FTIR)SPECTROMETER/SCANNING 
CONFOCAL LASER MICROSCOPE (SCLM) STUDIES OF ORAL MICROBIAL COMMUNITIES
 
NIH GUIDE, Volume 25, Number 6, March 1, 1996
 
RFP AVAILABLE:  NLM-96-104/VMS
 
P.T. 34

Keywords:
  Instrumentation, Biological 
 
National Library of Medicine
 
The National Institute of Dental Research (NIDR) has a requirement to
develop a Fourier-Transform-Infrared-Spectroscopy (FTIR) flowcell for
establishment and characterization for various conditioning films on
a substratum appropriate to the oral milieu (e.g., dental enamel),
and to reversibly install this flowcell on a Scanning Confocal Laser
Microscope (SCLM) located at the National Institute of Dental
Research (NIDR), NIH, thereby creating an instrument for on-line
four-dimensional study of microbial attachment to conditioning films.
The successful contractor will be provided access to the Leica TCS-4D
SCLM located at NIDR, to test the suitability of the flowcell for use
on the microscope stage to conduct preliminary tests.  Integration
onto the SCLM, and support to set necessary baseline parameters for
studying orally-relevant biofilms are required.  It is anticipated
that a two-year, cost reimbursement (level of effort) type contract
will be awarded.  The total project effort is estimated at 3,400
labor hours over the two year period of performance.  The skills of
trained and experienced analytical chemists, microbiologists,
microbial ecologists, materials science engineers and access to
laboratory-scale (developmental) and projection-scale prism-coating
facilities as well as analytical facilities (XPS, SIMS, and Auger)
will be essential for the successful completion of this project.
 
INQUIRIES
 
Request for Proposals (RFP) No. NLM 96-104/VMS will be available on
or about March 11, 1996, with proposals due on or about April 26,
1996.  All responsible sources may submit a proposal which will be
considered by the NIDR.  This acquisition is being managed for the
National Institute of Dental Research by the Office of Acquisitions
Management at the National Library of Medicine.  Verbal and FAX
requests for the RFP will not be accepted, requests must be submitted
in writing, addressed to:
 
Valerie M. Syed
Office of Acquisitions Management
National Library of Medicine
8600 Rockville Pike
Building 38A, Room B1N17
Bethesda, MD  20894


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