NATIONAL GENE VECTOR LABORATORIES NIH GUIDE, Volume 25, Number 4, February 16, 1996 P.T. 34 Keywords: Genetics Biological Resources Gene Therapy+ National Center for Research Resources National Cancer Institute National Heart, Lung, and Blood Institute National Institute of Diabetes and Digestive and Kidney Diseases The National Gene Vector Laboratories (NGVLs) provide shared resources to facilitate production of clinical grade vectors for human gene therapy research. The overall goals are to produce selected vectors and distribute them to qualified clinical investigators to conduct experimental gene therapy protocols for a wide variety of medical conditions. The NGVLs are now soliciting applications for production of clinical grade vectors. Priority for vector production by these facilities will be given to protocols that have received peer-reviewed grant support. These vectors must have completed preclinical testing. Preference will be given to NIH-sponsored research. Specifically, the NGVLs support biomedical research by providing investigators with the following customized services: PRODUCTION o After competitive review and approval, adenoviral, retroviral and nonviral vectors will be produced under Good Manufacturing Practices (GMP) conditions using either investigator- or NGVL-generated vector- producing cell lines or plasmids. o Vector batches will be documented to be free of adventitious viruses, bacteria and replication competent viruses. DISTRIBUTION o The clinical grade vectors will be distributed in quantities adequate for use in Phase I or II clinical trials to investigators whose clinical protocols have successfully completed competitive review by both the NGVL Scientific Review Board and Steering Committee. APPLICATION PROCEDURE o Interested investigators may contact Dr. Kenneth Cornetta (see INQUIRIES) to obtain application packages. o Applications will be reviewed by the NGVL Scientific Review Board and by the NGVL Steering Committee. o The application receipt dates for 1996 are April 16 and September 3. Thereafter, applications will be received annually in September. INQUIRIES Direct requests for applications and resource inquiries to: Kenneth Cornetta, M.D. Division of Hematology, Oncology Indiana University School of Medicine 875 W. Walnut Street, Room 442 Indianapolis, IN 46202-5121 Telephone: (317) 274-0843 FAX: (317) 274-4243 Email: Ken_Cornetta@iucc.iupui.edu Direct programmatic inquiries regarding this research resource to: Richard A. Knazek, M.D. Clinical Research National Center for Research Resources 6705 Rockledge Drive, Room 6128, MSC 7965 Bethesda, MD 20892-7965 Telephone: (301) 435-0792 FAX: (301) 480-3661 Email: RichardK@ep.ncrr.nih.gov The NGVLs are supported by cooperative agreement awards supported by the National Center for Research Resources with co-funding provided by the National Cancer Institute, the National Heart, Lung, and Blood Institute, and the National Institute of Diabetes and Digestive and Kidney Diseases. .
Return to NIH Guide Main Index
Office of Extramural Research (OER) |
National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892 |
Department of Health and Human Services (HHS) |
||||||||
Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files. |