NIH GUIDE, Volume 24, Number 39, November 3, 1995

P.T. 34



National Institute of Child Health and Human Development

The National Institute of Child Health and Human Development (NICHD)

Transgenic Mouse Development Facility (NTMDF) is a research resource

that develops transgenic mice for investigators requiring these

services.  It was established to provide reliable and affordable

transgenic mice in a timely manner primarily to biomedical research

grantees supported by the National Institutes of Health.

Specifically, the NTMDF supports basic biomedical research by

providing investigators with the following customized services:

o  Analyzing DNA constructs for microinjection.

o  Microinjecting DNA constructs into fertilized one-cell mouse eggs

and reimplanting them into pseudopregnant recipient females.

o  Testing potential founders for DNA integration.

o  Producing at least two transgenic (integration-positive) mice.

o  Fast turnaround time (10-12 weeks)

Information and applications for services should be requested from

the Director, NTMDF.  Completed applications may be submitted anytime

to the NTMDF Director for review.  Review is completed within two

weeks of receipt.  All applications are handled confidentially and

those DNA constructs approved are microinjected at the NTMDF.  The

Investigator is charged a non-refundable fee of $500 per construct

for initial analysis.  An additional fee of $2000 per construct is

assessed if two or more transgenic mice are produced.  The NTMDF is

supported by a contract award from the National Institute of Child

Health and Human Development, NIH.


Direct requests for information and applications regarding this

research resource to:

Carl A. Pinkert, Ph.D., Director

NICHD Transgenic Mouse Development Facility

c/o The University of Alabama at Birmingham

1670 University Boulevard, VH-227

Birmingham, AL  35294-0019

Telephone:  (205) 934-2998


Direct programmatic inquiries to:

Allan Lock, D.V.M.

NTMDF Project Officer

National Institute of Child Health and Human Development

Building 6100, Room 4B01, MSC-7510

Bethesda, MD  20892-7510

Telephone:  (301) 496-5541

Email:  LockA@HD01.NICHD.NIH.GOV


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