NIH GUIDE, Volume 24, Number 17, May 12, 1995




National Cancer Institute

The National Cancer Institute (NCI) is seeking contractors qualified

to perform Phase II Clinical Trials that are small short-term,

efficient studies of potential chemopreventive agents.  This work

includes small, short term, efficient studies to determine the dose

of given chemopreventive agent that exhibits a pharmacodynamic effect

on an intermediate endpoint.  These studies will also require dose

response studies to determine the minimum dose at which a biological

effect is observed and confirmation of the maximum safe dose, and the

performance of randomized blinded trials in small groups of subjects

whose endpoints will be the measurable biological effect of the agent

versus a placebo.  The solicitation is an annual announcement to

expand a current pool of Master Agreement (MA) Holders qualified to

perform this type of work.  Individual work requirements will be

defined, as the need arises, by Master Agreement Orders (MAOs) issued

during the period of performance, and MAOs will be awarded based upon

competition between members of the MA pool.  The solicitation will be

released on or about May 12, 1995, with proposals due July 14, 1995.


The Contracting Officer for this solicitation is Richard L. Hartmann,

telephone (301) 496-8603.  Copies of the RFP may be obtained by

sending a written request to:

Ms. Desiree Sylver-Foust

Research Contracts Branch

National Cancer Institute

Executive Plaza South, Suite 635

Bethesda, MD  20892

Telephone:  (301) 496-8603


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