THE HUMAN BRAIN PROJECT: PHASE I FEASIBILITY STUDIES NIH GUIDE, Volume 23, Number 33, September 16, 1994 PA NUMBER: PA-93-068 P.T. 34 Keywords: Brain Neuroscience Information Science/Systems National Institute of Mental Health National Institute on Drug Abuse National Institute on Aging National Institute on Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Library of Medicine Fogarty International Center National Institute of Dental Research National Heart, Lung, and Blood Institute National Institute on Alcohol Abuse and Alcoholism National Science Foundation Office of Naval Research National Aeronautics and Space Administration Department of Energy For those intending to apply for grants under the Human Brain Project, this addendum is meant to supplement the program announcement PA- 93-068; NIH Guide, Vol. 22, No. 13, April 2, 1993, which is still in effect and must be consulted in conjunction with this addendum. The Human Brain Project is a broadly based Federal research initiative, supported in a coordinated fashion by 14 Federal organizations across five Federal agencies. The general purpose of this initiative is to encourage and support investigator-initiated, basic and clinical neuroscience and behavioral research and development of computer-based resources that could be used to facilitate research on the brain and its functions. Particular emphasis is placed on research and development of tools and approaches to store and manipulate information about the brain and behavior, as well as electronic network technologies which will give scientists access to the stored information and the ability to integrate and synthesize information. The network tools will also provide electronic channels of communication and collaboration to geographically distant laboratories. These capabilities and approaches are referred to here as informatics and include areas such as computer science, mathematics, statistics, and engineering. The combination of brain and behavioral research with informatics research constitutes the developing field of neuroinformatics. To optimize their utility to brain and behavioral researchers, these technologies and approaches will be developed in the context of specific, ongoing, research on the brain and its functions. Thus, all applications need to have an informatics science research component as well as a research component related to the brain and/or behavior. It is, therefore, expected that each application will include a multidisciplinary research team. Application components related to ethical, legal, and social issues pertinent to this initiative are encouraged. Also encouraged are components of applications that are designed to reach out to the public, academic, and/or commercial sectors and educate them about the opportunities that are presented by research and development of neuroinformatics. Participation in an Annual Spring Meeting held in the Washington, DC area is encouraged. In applications for the R01 mechanism, funds to support travel to this meeting should be included in the budget for the principal investigator and up to one additional key member of the research team. In applications for the P20 mechanism, funds to support travel to this meeting should be included in the budget for the principal investigator (the director of the grant), the director of each subproject, and up to one additional key member from the P20 research team. All applications for these feasibility research grants should include a detailed, year-by-year timetable of specific goals. Applications should: o Contain both a brain and/or behavioral research component AND an informatics research component that are well integrated and which promise to move both fields forward o Include a specific plan to monitor progress and evaluate tools and approaches being developed Dates for the submission and resubmission of Phase I Human Brain Project applications and review cycles are as follows: Letter of Intent Receipt Date: July 1 Application Receipt Date: October 15 Administrative Review: October Scientific Review: February/March Advisory Council Review: May/June Earliest Start Date: July It should be noted that there is no additional receipt date for resubmitted applications or for competitive continuations (i.e., renewals). All applications, initial submissions, resubmissions, and competitive continuations will be received only once a year, October 15. Applicants may apply for Interactive Research Project Grants (IRPGs) in addition to the R01 and P20 mechanisms. The IRPG allows for formal interactions between and among research efforts that are funded independently. The IRPG encourages collaborative relationships that do not require extensive, shared, physical resources. A minimum of two independent investigators may submit concurrent, collaborative, cross-referenced individual R01/R29 applications. The proposed projects must not be dependent on each other to the extent that one could not be accomplished in the absence of the other. Applications may be from one or more institutions. Applications will be reviewed independently for scientific merit. Applications judged to have significant and substantial scientific merit will be considered for funding both as independent awards and in the context of the proposed IRPG collaboration. Those interested in applying for an IRPG should consult Program Announcement PA-94-086, NIH Guide, Vol. 23, Number 28, July 29, 1994. Grantees will be encouraged to take steps to perfect copyright protection of software produced as a result of Human Brain Project funding. These should include prominent notification in the software and its documentation that the software is copyrighted. Notification could consist of the following: "c Copyright [year] by [your name, the names of you and your colleagues, or the name of your institution] with funding from the Human Brain Project." This notification will identify the source of the software and help ensure that the software can be shared freely while protecting any commercial rights in it. In addition, grantees will be required to agree that they will provide the primary funding organization, upon its request and at a reasonable cost, a copy of any software produced under Human Brain Project funding, with the understanding that the Federal organizations directly involved with the Human Brain Project will have the right to use such software for internal research and archival purposes only and will not permit its distribution beyond those organizations. INQUIRIES Women, minorities, and those with disabilities are especially encouraged to apply. Potential applicants are strongly encouraged to contact the Agency or Institute representative to discuss their plans prior to preparing an application. The names of the representatives from each of the participating Agencies, Institutes, and Center may be obtained from: Michael F. Huerta, Ph.D. National Institute of Mental Health 5600 Fishers Lane, Room 11-103 Rockville, MD 20857 Telephone: (301) 443-5625 FAX: (301) 443-1731 E-mail (internet): HMI@CU.NIH.GOV .
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