NIH GUIDE, Volume 23, Number 37, October 21, 1994


P.T. 04


  Cardiovascular Diseases 

  Clinical Trial 


  Data Management/Analysis+ 

National Heart, Lung, and Blood Institute

The National Heart, Lung, and Blood Institute (NHLBI) is soliciting

proposals from organizations to serve as a clinical coordinating

center in a multicenter trial to determine the effects of

psychosocial interventions on morbidity and mortality in coronary

heart disease (CHD) patients.  The primary objective of this

multicenter trial is to evaluate the effects of psychosocial

interventions on the cardiac-related morbidity and mortality of

myocardial infarct (MI) patients at high psychosocial risk.  High

psychosocial risk is defined as the presence of depression and/or

social isolation.  The study design will compare a psychosocial

intervention group, in which patients are provided with social

support and psychological treatment designed to decrease social

isolation and depression, with a health education control and a

standard medical care group, using a combined endpoint of CHD death

plus reinfarction.  Secondary endpoints include health-related

quality of life; adherence to medications and health-promoting

behaviors; and ischemic events, measured by ambulatory

electrocardiogram and exercise tolerance testing.  To accomplish its

objective, this program proposes to award approximately eight

clinical units for patient accession, intervention, and data

collection and one clinical coordinating center for study

coordination and data management.  It is anticipated that a total of

3,000 patients will be enrolled.

This is an announcement for a Request For Proposals (RFP).  RFP

NHLBI-HC-94-29 is now available and proposals are due November 18,

1994.  One award is anticipated by the Government.  The period of

performance for the clinical coordinating center is anticipated for

eight years beginning in August 1995.


Written requests for this solicitation must include three self-

addressed mailing labels and cite RFP NHLBI-HC-94-29.  Verbal

requests must be confirmed in writing or by FAX.  Requests for the

solicitation are to be addressed to:

Cheryl A. Jennings

Contracts Operations Branch

National Heart, Lung, and Blood Institute

Federal Building, Room 3C16

7550 Wisconsin Avenue

Bethesda, MD  20892

Telephone:  (301) 496-1326

FAX:  (301) 496-0075


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