NIH GUIDE, Volume 23, Number 14, April 8, 1994




National Heart, Lung, and Blood Institute

This announcement revises the issue and response dates, the award

date, and the number of anticipated awards for Request for Proposals

(RFP) No. NHLBI-HC-94-13 published in the NIH Guide for Grants and

Contracts, Vol. 23, No. 11, March 18, 1994.  RFP NHLBI-HC-94-13 is

now available and proposals are due on June 30, 1994.  Three to five

awards are anticipated to be made in March 1995.

The National Heart, Lung, and Blood Institute (NHLBI) requires three

to five clinical centers to evaluate innovative diagnostic methods

that will improve the diagnostic reliability of cardiovascular

testing in evaluation of ischemic heart disease in women.  Innovative

approaches proposed in evaluation of myocardial ischemia should

include physiologic or functional measurements such as impaired

metabolism, perfusion, or endothelial function as well as assessment

of epicardial coronary arteries by angiography.  Each clinical center

will be fully independent and expected to fulfill all the

requirements outlined in this RFP.  The clinical centers will

evaluate diagnostic methods and perform common study protocols,

including angiography, on 100 participants annually for three years.

The anticipated period of performance is from March 1, 1994 through

February 28, 1999.


For a copy of the RFP send a written request, citing RFP No.

NHLBI-HC-94-13, to:

Donna J. Neal

Contracts Operations Branch

National Heart, Lung, and Blood Institute

Federal Building, Room 3C16

7550 Wisconsin Avenue

Bethesda, MD  20892


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