EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN VIVO SCREENING ASSAYS

NIH GUIDE, Volume 23, Number 13, April 1, 1994



RFP AVAILABLE:  NCI-CN-45000-46



P.T.





Keywords:



National Cancer Institute



The National Cancer Institute (NCI), Division of Cancer Prevention

and Control, Chemoprevention Branch, wishes to award Master Agreement

(MA) contracts for the evaluation of chemopreventive agents by in

vivo screening assays.  The required services will be defined by

Master Agreement Orders (MAO) issued during the four year period of

performance.  This solicitation is the annual announcement to expand

the current pool of MA Holders qualified to perform this type of

work.  All interested offerors must submit proposals to be eligible

to compete for future MAO RFPs.  Pursuant to the MAO the Contractor

will conduct in vivo screening studies in small rodents using gavage

and other routes of administration to administer the designated

chemopreventive agents in animal models using any carcinogenic

mechanism (that is consistent with the Evaluation Criteria), such as

the administration of carcinogens, promoters, hormones, irradiation,

cells or other carcinogenic agents.  Agents to be tested are

potentially hazardous.  The animal model systems also involve the use

of carcinogens.  Laboratory practices that keep any element of risk

to personnel at an absolute minimum will be employed.  Where

indicated, tissue and compound handling must be performed in (at

least) Class I laminar flow agents.  It is required that the animal

facilities be maintained in accordance with the NIH Guide for the

Care and Use of Laboratory Animals, the Animal Welfare Act as

administered by the USDA, and the U.S. Government Principals for

Utilization and Care of Vertebrate Animals Used for Testing Research

and Training.  This research will be performed under cost

reimbursement and/or fixed price MAO's.  The contractor must have all

the equipment necessary to accomplish the studies including, but not

limited to, animal racks and caging, hazardous chemical storage

cabinets and refrigerators, pathology equipment such as microscopes

and microtomes and miscellaneous laboratory equipment.  The

laboratory must have or have access to appropriate terminal and

computer facilities and equipment for data collection and storage.

It is estimated that four to five Task Orders per year will be issued

pursuant to the Master Agreement contracts.  The Master Agreement

Announcement will be available on approximately March 25, 1994.

Proposal due date will be approximately May 24, 1994.



INQUIRIES



Copies of the MAA/RFP NCI-CN-45000-46 may be obtained by sending a

written request to:



Mr. Schuyler T. Eldridge

Research Contracts Branch

National Cancer Institute

Executive Plaza South, Suite 635,

Bethesda, MD  20892

Telephone:  (301) 496-8603



Collect calls will not be accepted.



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