NIH GUIDE, Volume 23, Number 12, March 25, 1994




National Institute of Environmental Health Sciences

The National Institute of Environmental Health Sciences (NIEHS),

National Institutes of Health (NIH), is soliciting proposals from

offerors that have the capabilities and facilities for the following:

Phase 1 -- Using the methodology developed under the contract

N01-ES-05290 "Expired Breath Analysis in Chemical Toxicity

Assessment," the contractor design of a series of experiments to

determine changes in the relative production rate (normalized to CO2

production) of the various breath components in male or female F344

rats exposed to various chemical treatments.  These treatments will

include specific inhibitors or inducers of as many cytochrome P450

isoforms as can be evaluated in the rat, including forms of the

enzymes involved in steroid metabolism.  The contractor will propose

experiments to study the effect of modulation of tissue glutathione

levels in relation to changes in expired breath components; Phase 2

will consist of one of two selected tasks.

The Government estimates that the project will require approximately

1.5 professional person-years per contract year.  The estimated

period of performance is three years.


Release of the RFP is anticipated on or about March 21, 1994 with

proposals due May 2, 1994.  All responsible sources may submit a

proposal that will be considered by the Agency.  Requests must

reference RFP No. NIH-ES-94-27 and must be directed to:

Howard Hill

Contracts and Procurement Management Branch

National Institute of Environmental Health Sciences

79 T.W. Alexander Drive, Building 4401 Research Commons

P.O. Box 12874

Research Triangle Park, NC  27709

Telephone:  (919) 541-4971

FAX:  (919) 541-2712


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