EXPIRED BREATH ANALYSIS IN CHEMICAL TOXICITY ASSESSMENT NIH GUIDE, Volume 23, Number 12, March 25, 1994 RFP AVAILABLE: NIH-ES-94-27 P.T. Keywords: National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), is soliciting proposals from offerors that have the capabilities and facilities for the following: Phase 1 -- Using the methodology developed under the contract N01-ES-05290 "Expired Breath Analysis in Chemical Toxicity Assessment," the contractor design of a series of experiments to determine changes in the relative production rate (normalized to CO2 production) of the various breath components in male or female F344 rats exposed to various chemical treatments. These treatments will include specific inhibitors or inducers of as many cytochrome P450 isoforms as can be evaluated in the rat, including forms of the enzymes involved in steroid metabolism. The contractor will propose experiments to study the effect of modulation of tissue glutathione levels in relation to changes in expired breath components; Phase 2 will consist of one of two selected tasks. The Government estimates that the project will require approximately 1.5 professional person-years per contract year. The estimated period of performance is three years. INQUIRIES Release of the RFP is anticipated on or about March 21, 1994 with proposals due May 2, 1994. All responsible sources may submit a proposal that will be considered by the Agency. Requests must reference RFP No. NIH-ES-94-27 and must be directed to: Howard Hill Contracts and Procurement Management Branch National Institute of Environmental Health Sciences 79 T.W. Alexander Drive, Building 4401 Research Commons P.O. Box 12874 Research Triangle Park, NC 27709 Telephone: (919) 541-4971 FAX: (919) 541-2712 .
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