CLINICAL CENTERS FOR VIRAL ACTIVATION TRANSFUSION STUDY

NIH GUIDE, Volume 23, Number 6, February 11, 1994



RFP AVAILABLE:  NHLBI-HB-94-12



P.T.





Keywords:



National Heart, Lung, and Blood Institute



This study will determine if viral activation occurs following blood

transfusion and if leukocyte depletion or irradiation can prevent it.

It also will evaluate the role of donor leukocytes producing this

activation by examining the effects of removing leukocytes by

filtration or abolishing their ability to proliferate by gamma

irradiation.  Finally, the study will examine the persistence of

donor lymphocytes after transfusion.  The project will require a

total of at least 330 HIV-1 infected patients with CD4 counts below

250 cells/mm3 prior to their transfusion.  Each clinical center will

be expected to recruit and follow at least 33 patients in accordance

with protocol requirements.  Responsibilities will include, but are

not limited to, the following:  (1) participate as a member of the

Steering Committee in finalizing details of the protocol and in

completing the manual of operations; (2) coordinate with a blood

bank, the preparation and transfusion of blood products for the

patients; (3) collect clinical data on each patient and perform

regular physical exams on the patients; (4) collect blood samples

from patients for testing by a centralized laboratory; (5) transmit

scientific data to a medical coordinating center; (6) participate in

all committee and any subcommittee meetings; and (7) participate in

developing and writing scientific presentations and manuscripts for

publication.  It is anticipated that several awards will be made from

this solicitation and that awards will be made on or about September

30, 1994.  It is anticipated that the awards will be multiple-year

cost reimbursement completion contracts with a term of three years.



INQUIRIES



RFP No. NHLBI-HB-94-12 was released on January 26, 1994.  Requests

for copies of the RFP must include three self-addressed mailing

labels and are to be directed to:



Lynda A. Bindseil

BDR Contracts Section

National Heart, Lung, and Blood Institute

7550 Wisconsin Avenue

Federal Building, Room 610

Bethesda, MD  20892



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