SYNTHESIS OF CONGENERS AND PRODRUGS NIH GUIDE, Volume 23, Number 4, January 28, 1994 RFP AVAILABLE: NCI-CM-47012-20 P.T. Keywords: National Cancer Institute The Drug Synthesis and Chemistry Branch (DS&CB) of the Developmental Therapeutics Program (DTP), Division of Cancer Treatment (DCT), National Cancer Institute (NCI) is seeking contractors with expertise in chemical synthesis and drug design to synthesize a variety of compounds for evaluation as potential anti-AIDS or anti-cancer agents. The assigned objectives of this project are to design and synthesize the following: (a) congeners of lead compounds having confirmed activity to enhance activity or potency; (b) prodrugs with structural modifications that may provide altered pharmacokinetics, altered drug transport, improved bio-availability through increased water solubility, or increased chemical stability; (c) other altered structures that possess elements of both congeners and prodrugs; and (d) compounds related to natural products, e.g., alkaloids, heterocycles, nucleosides, and peptides. Each contractor should have available a fully operational facility, including all necessary equipment and instrumentation for all aspects of the contract. The nature of this project requires that the following restriction be applied: "The NCI signs legally binding agreements with certain suppliers (often pharmaceutical or chemical companies) that state that all information on compounds submitted by the supplier will be held confidential. The successful offeror will be expected to synthetically modify such commercially confidential (discreet) materials. Thus, pharmaceutical or chemical companies could obtain valuable data on new lead compounds. Therefore, in order to honor the confidentiality agreement with the original supplier, the NCI believes that the compounds cannot be sent to potential competitors of the supplier, and thus pharmaceutical and chemical companies must be excluded from the competition." For purposes of this restriction, a pharmaceutical or chemical company is defined as an organization that sells drugs and chemicals to the general public for profit. The Standard Industrial Classification (SIC) number is 8731. This is a recompetition of contracts currently held by the Georgia Tech Research Corporation (Georgia Institute of Technology), Purdue Research Foundation, and the University of Tennessee. It is anticipated that two cost-reimbursement contracts will be awarded for a period of two years beginning on or about September 30, 1994. INQUIRIES Request for Proposals (RFP) No. NCI-CM-47012-20 will be issued on or about January 31, 1994 and proposals will be due approximately 30 days thereafter. Copies of the RFP may be obtained by sending a written request to: Charles Lerner Research Contracts Branch, TCS National Cancer Institute Executive Plaza South, Room 603 Bethesda, MD 20892 Telephone: (301) 496-8603 .
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