PRECLINICAL PHARMACOLOGICAL STUDIES OF ANTITUMOR AND ANTI-HIV AGENTS NIH GUIDE, Volume 23, Number 3, January 21, 1994 RFP AVAILABLE: NCI-CM-57199-12 P.T. 34 Keywords: Pharmacology Chemotherapeutic Agents National Cancer Institute The Developmental Therapeutics Program (DTP), Division of Cancer Treatment, is soliciting organizations having the necessary experience, scientific and technical personnel, and facilities to conduct a series of preclinical pharmacokinetic and other pharmacology studies in non-disease bearing animals on agents having demonstrated antitumor or anti-HIV activity and considered by DCT to merit further development. The studies to be performed will include: the development of methodology for the quantitative measurement of test agents and/or metabolites in animal body fluids and tissues; stability studies of test agents in biological fluids; plasma protein binding determinations; characterization of in vivo plasma concentration-time profiles and calculation of relevant pharmacokinetic parameters; determination of test agent levels in samples provided by other DTP contractors; determination of the most effective mode of agent administration to achieve and maintain effective concentrations in body fluids and tissues; bioavailability studies following administration of an agent by various routes; tissue distribution and urinary excretion studies; structural determination of metabolites and/or degradation products of parent agents produced in animals and in model in vitro systems (e.g., animal and/or human liver slices, S9 fractions, and microsomal preparations). Where appropriate, this information will be related to mechanisms of antitumor or antiviral action. The Government will supply all animals (mice, rats, dogs, non-human primates), test agents, and radiolabeled test agents. Contractors will be expected to provide all equipment, solvents, reagents and animal facilities needed to conduct this type of work. AAALAC accreditation is highly desirable and is required by time of award. It is anticipated that four to five awards will be made as a result of the Request for Proposal (RFP), each for a three to five year, incrementally-funded level-of-effort contract. Only one award will be made to an institution. The following Mandatory Qualification Criteria will apply: (1) the Contractor may not be a pharmaceutical or chemical firm since agents of a commercially confidential nature (discreet) may be evaluated; (2) since structural formulas and other information on discreet agents may be included in a Task Order Request, contractors must be willing to sign a confidentiality of information statement; (3) the Contractor must possess a valid NRC license permitting the purchase, storage, and use of typical quantities of radioisotopes (e.g., 3H, 14C, 35S) likely to be used in the proposed pharmacological research. INQUIRIES RFP No. NCI-CM-57199-12 will be issued on or about January 18, 1994 and proposals will be due approximately March 4, 1994. Copies of the RFP may be obtained by sending a written request to: Ms. Joyce A. Crooke Research Contracts Branch, TCS National Cancer Institute Executive Plaza South, Room 603 Bethesda, MD 20892 Telephone: (301) 496-8620 No collect calls will be accepted. .
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