EARLY DETECTION RESEARCH NETWORK NIH GUIDE, Volume 23, Number 1, January 7, 1994 MAA AVAILABLE: NCI-CN-45580-63 P.T. 34 Keywords: Tissue Culture Biochemical Markers Cancer/Carcinogenesis Biology, Cellular National Cancer Institute The Division of Cancer Prevention and Control, National Cancer Institute (NCI), in its annual requirement to seek new sources, is soliciting proposals for the Early Detection Research Network (EDRN) to increase the number of Master Agreement (MA) Holders originally awarded under MAA No. NCI-CN-15340-04. Current MA Holders for this program are not required to submit a proposal. The Master Agreement Announcement (MAA) is issued to solicit MA holders who have knowledge in establishing a biorepository of normal premalignant and malignant tissues by collecting and storing tissues and associated fluids to identify potential cellular and molecular markers for early detection. The project will focus on tissues of the colon and rectum, lung, prostate, and urinary bladder. There will be an associated database with demographic information, exposure to potential carcinogens, and risk factors on the subjects from whom specimens have been obtained; and expertise in conducting cellular and molecular studies on these tissues with the goal of developing new procedures assessing the sequence of genetic alterations in protooncogenes, analyzing allelic deletions of suppressor genes, identifying activated oncogenies, identifying oncogene products suitable for evaluating neoplastic progression, and developing cellular and molecular markers that will identify individuals who are at high risk of cancer. INQUIRIES Requests for this solicitation must be in writing and reference MAA No. NCI-CN-45580-63. The Master Agreement Announcement (MAA) is now available and responses will be due approximately COB January 28, 1994. Requests are to be addressed to: Ms. Tina Huyck Research Contracts Branch, PCCS National Cancer Institute Executive Plaza South, Room 635 Bethesda, MD 20892 Telephone: (301) 496-8603 .
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