PREPARATION OF IMMUNOCONJUGATES NIH GUIDE, Volume 22, Number 44, December 10, 1993 MAA AVAILABLE: NCI-CM-47017-37 P.T. 34 Keywords: Monoclonal Antibodies Proteins and Macromolecules Biological Resources National Cancer Institute This is a resolicitation of the above subject Master Agreement Announcement. Existing Master Agreement holders need not reapply. This project was originally synopsized as a Master Agreement Announcement under NCI-CM-27731. The National Cancer Institute (NCI), Division of Cancer Treatment (DCT), Biological Resources Branch (BRB), is soliciting proposals to prepare preclinical and clinical grade immunoconjugates of monoclonal antibodies, antibody fragments, peptides, and/or other genetically engineered targeting molecules that are linked to chelating agents. The NCI will provide purified monoclonal antibodies, antibody fragments, or other targeting molecules to the contractor for chemical conjugation of chelating agents that will bind specific radionuclides for imaging and/or therapy. The Offeror will use procedures that have either appeared in the peer reviewed literature or protocols that have been developed by the NCI and will be supplied to the Offeror. In addition, proprietary technology developed by the Offeror to prepare the desired immunoconjugates would also be considered. These immunoconjugates will be used to prepare radioimmunoconjugates for both preclinical and clinical applications. All synthetic and purification procedures will be performed under Good Laboratory Procedures (GLP) and/or Good Manufacturing Practice (GMP). It is anticipated that the Offeror will be required to prepare approximately 50 to 1000 mg of each immunoconjugate. The Offeror will evaluate these immunoconjugates for purity, stability, immunoactivity, and other criteria specified by the NCI. One or more awards may be made to qualified offerors responding the MAA. A Master Agreement (MA) is the instrument issued to sources who respond to a Master Agreement Announcement, and who are judged to be qualified to compete for future orders issued under the general project area or areas described in the MA. MAs are competitively negotiated and awarded to more than one organization. This type of agreement is designed to accomplish highly circumscribed pieces of work as promptly as possible. The MAs that will be awarded under this MAA will not be funded per se. After award, MA Holders will be invited to propose on MA Orders (MAOs) as they are issued. An MAO is a bilateral award document issued to an MA Holder who successfully competed for requirements described in an MAO RFP. Individual MAOs will be issued on either a completion or term (level of effort) basis, whichever is deemed appropriate by the Contracting Officer. INQUIRIES MAA NCI-CM-47017-37 is now available. Responses will be due by 3:30pm, January 28, 1994. Copies of the RFP may be obtained by sending a written request to: Mrs. Patricia Lightner Research Contracts Branch National Cancer Institute Executive Plaza South, Room 603 Bethesda, MD 20892 .
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