ANIMAL MODEL TESTING OF TUBERCULOSIS DRUGS

NIH GUIDE, Volume 22, Number 33, September 17, 1993



RFP AVAILABLE:  NIAID-DAIDS-94-25



P.T.





Keywords:



National Institute of Allergy and Infectious Diseases



The Developmental Therapeutics Branch, Basic Research and Development

Program, Division of AIDS, National Institute of Allergy and

Infectious Diseases (NIAID), has a requirement for animal model

testing of potential therapies against Tuberculosis (TB).  The

Contractor will be required to:  test potential therapeutic agents

for efficacy in a mouse model and provide relevant strains of TB to

do so; demonstrate the ability to modify or improve the proposed

model and design alternative protocols; perform additional studies

such as efficacy in models or acute infection measuring mortality as

the endpoint, comparison of different strains of TB in efficacy

evaluations, determinations of optimal dosages, routes, and schedules

of administration.  Offerors must have a Bio-Safety Level 3 animal

facility at time of award to be considered.  Therapeutic agents to be

evaluated will be supplied by the Government, through a contract to

be awarded for the acquisition of compounds for TB research.



This announcement is for a new solicitation and it anticipated that

there will be one award made.  The issuance of the Request for

Proposals (RFP) will be on or about September 17, 1993, with

proposals due by COB on or about December 17, 1993.  A five-year,

cost-reimbursement contract is anticipated.



INQUIRIES



Requests for the RFA may be directed to:



Mr. Bruce E. Anderson

Contract Management Branch

National Institute of Allergy and Infectious Diseases

Solar Building, Room 3C07

6003 Executive Boulevard

Bethesda, MD  20892

Telephone:  (301) 496-8371

FAX:  (301) 402-0972



A short-form version of the RFA will be available, for informational

purposes, which includes only the background information, the full

Statement of Work, and Evaluation Criteria.  There is sufficient

information in this document to enable prospective offerors to

determine if they have the expertise/capability to meet the

Government's requirements.  A full-text version will also be

available, which includes all the necessary information, business

forms, etc., in order to submit a proposal.  There are a limited

number of full-text versions available.  Therefore, request the

short-form RFP first, then the full-text version only if you are

going to submit a proposal.  All request must be in writing.  Specify

whether you are requesting the short version or full-text version of

the RFP.  FAX requests are acceptable, but it is preferred that

requests be made in writing and two self-addressed mailing labels be

provided.



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