INTERACTIVE RESEARCH PROJECT GRANT APPLICATION RECEIPT AND FUNDINGPOLICIES NIH GUIDE, Volume 22, Number 31, August 27, 1993 P.T. 34 Keywords: Cancer/Carcinogenesis Grants Administration/Policy+ National Cancer Institute The National Cancer Institute (NCI) initiated the concept of the interactive research project grant (IRPG) in January 1992 with the publication of NIH Program Announcement PA-92-29 (NIH Guide for Grants and Contracts, Vol. 21, No. 1, January 10, 1992). This was followed by Program Announcements in Digital Mammography (PA-92-57, NIH Guide for Grants and Contracts, Vol. 21, No. 12, March 27, 1992), and Magnetic Resonance Spectroscopy and Cancer Treatment (PA-92-86, NIH Guide for Grants and Contracts, Vol. 21, No. 22, June 12, 1992). Policies pertaining to these and all subsequent IRPG solicitations, whether initiated by the NCI or another NIH Institute or Center, are now subsumed under the NIH-wide program announcement PA-93-078, entitled "Investigator Initiated Interactive Research Project Grants" (NIH Guide for Grants and Contracts, Vol. 22, No. 16, April 23, 1993). The items that differ from the previous NCI IRPG solicitations as specified in the NIH-wide announcement are: (a) to reduce the minimum number of required projects from three to two; and (b) clarification of the nature and content of the information to be provided under Section 7 (Consultants/Collaborators) of the form PHS 398 application kit. It is the policy of the NCI to accept unsolicited IRPG applications in all areas of cancer research appropriate to the mission of the NCI as delineated in the PHS referral guidelines. Applications received in response to IRPG program announcements normally will be assigned to the appropriate Institute and study sections of the Division of Research Grants according to the PHS referral guidelines. AWARD CRITERIA The general principles to be employed by the NCI in consideration of funding individual components of IRPGs received in response to program announcements will be those that apply to all R01 awards; that is, applications must fall within the R01 payline to be ranked for immediate funding. In addition, however, if any individual application within an IRPG set falls within the natural R01 payline at the time of review, the NCI will consider selected additional applications within the set with scores better than the 35th percentile as possible candidates for funding as exceptions, especially if such applications fall within scientific areas designated as high priority by the NCI. Currently, these high priority areas include cancer of the breast, prostate, and ovary. Continuing commitments and current limitations on available research project grant (RPG) funds have affected the success rates of IRPGs, as they have with all other RPG mechanisms. Experience to date with IRPGs indicates that, as for new (Type 1) R01 applications in general, few original Type 1 applications submitted as components of IRPG sets are likely to be scored within the established payline of the NCI; it is consequently far less likely that more than one application in any IRPG set will be scored within that payline. If one or more, but not all, applications within an IRPG group receive initial funding, and unfunded applications within that group are subsequently amended and submitted on later receipt dates, the awarded IRPG component(s) should be identified and may be cited in the amended applications. This situation will be considered as forming a basis for subsequent exception funding for the resubmitted amended applications should their percentile ranking place them outside the then-current payline. In such cases, those amended R01 applications must make reference to being part of a partially funded IRPG. They may, however, request support to extend beyond the end date of the already awarded component R01(s), consistent with the scientific goals of the application. The National Cancer Institute intends to publish annually a list of updated high priority areas for Interactive Research Project Grants. While all IRPG applications outside these areas will be fully considered for regular funding under current paradigms, the extreme stringency of success rates for NCI R01 awards in general suggests that potential IRPG applicants proposing to conduct research in lower priority areas should be cautioned, therefore, to limit submission of interactive projects to those that are most fully conceptualized and integrated and that are felt to have the best chance of receiving funding as independent research efforts. INQUIRIES Applicants with questions regarding NCI policies pertaining to these awards are encouraged to contact an NCI program director or: Deputy Director Division of Extramural Activities National Cancer Institute Telephone: (301) 496-4218 FAX: (301) 402-0956 .
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