FINAL FINDINGS OF SCIENTIFIC MISCONDUCT NIH GUIDE, Volume 22, Number 27, July 30, 1993 P.T. 34 Keywords: Ethics/Values in Science & Technol Public Health Service Notice is hereby given that The Public Health Service's Office of Research Integrity (ORI) has issued final findings of scientific misconduct and has implemented administrative actions in the following case: Torrey Johnson, Tufts University. An inquiry and a subsequent investigation conducted by the University found that Mr. Johnson, a predoctoral graduate student in the Department of Biology, had fabricated research data on the genetic control of spermatogenesis. Mr. Johnson worked on a grant from the National Institute of Child Health and Human Development (R01 HD 11878). The university investigation concluded that Mr. Johnson's reports that he had extracted, purified, and characterized a transcription factor protein were fabricated. Mr. Johnson's notebooks provided no details on the purification procedures and he was unable to describe to his thesis committee the steps used to purify the protein. The investigation also concluded that it was likely that Mr. Johnson had used commercially- obtained human transcription factor instead of the claimed purified protein from mouse testis. The ORI concurred in the University's findings, and Mr. Johnson has been debarred from receiving Federal grant or contract funds for a three year period beginning May 14, 1993. For two years beyond the debarment period, any research institution which employs Mr. Johnson must provide the Public Health Service (PHS) a plan for the oversight of his scientific activities and certify the accuracy and integrity of information provided in PHS applications or in reports generated under a PHS award. Two abstracts containing fabricated data were withdrawn ("Footprint analysis of the promoters of mouse and rat protamine 2 genes reveals differences in protein binding" XIth North American Testis Workshop, and "Protein binding to a conserved promoter element of the male germ cell specific mouse protamine 1 and 2 genes suppresses transcription in vitro in non- expressing tissues" J. Cell Biology Abstracts, 115: 48a, 1991). INQUIRIES The Office of Research Integrity will continue to publish findings of scientific misconduct as further cases are closed. For further information, contact: Director, Division of Research Investigations Office of Research Integrity Telephone: (301) 443-5330 .
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