LARGE SCALE PRODUCTION OF 17APLHA-ACETOXY-11BETA-(4-N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE- 3,20-DIONE



NIH GUIDE, Volume 22, Number 23, June 25, 1993



SOURCES SOUGHT ANNOUNCEMENT



P.T. 34



Keywords:

  Contraceptives 

  Chemical Synthesis 

  Chemistry, Organic 



National Institute of Child Health and Human Development



The Contraceptive Development Branch, National Institute of Child

Health and Human Development (NICHD), seeks sources for pilot scale

production of 2 kilograms of

17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)- 19-norpregna-4,

9-diene-3,20-dione under Good Manufacturing Practices (GMP).  The

pilot scale plant facilities also must meet and comply with

requirements of the Occupational Safety and Health Administration

(OSHA).  The chemical purity of the final product must be greater

than or equal to 95 percent.  The synthetic scheme for the lead

compound, which involves 11 steps starting from estrone in a

laboratory scale, will be available immediately upon written request.



This is a sources sought announcement to determine whether or not

there are sources with the requisite qualifications to perform the

work described above.  Interested organizations may submit, within 30

days from the date of this announcement, time estimates for

furnishing 2 kilograms of material as well as a specific description

of their capability, including currently available pilot plant

facilitates with GMP approval.  The statement of capabilities may be

sent to:



Paul J. Duska, Contracting Officer

Contracts Management Branch, OGC

National Institute of Child Health and Human Development

Building 6100, Room 7A07

Bethesda, MD  20892



.

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