NIH Guide, Volume 22, Number 16, April 23, 1993


P.T. 34


  Tissue Culture 

  Diagnosis, Medical 


National Cancer Institute

The National Cancer Institute (NCI) is seeking experienced

organizations able to access and provide large numbers of paraffin

embedded tumor tissues (and where available, frozen tumor specimens)

with associated patient follow-up data to be used for the validation of

promising new diagnostic and prognostic assays.  The tumor tissue

required and the assays to be performed will be defined by Master

Agreement Orders (MAOs) issued during the period of performance.  The

MAOs will be based upon competition between members of the Master

Agreement (MA) pool.  MA Holders who successfully bid on specific MAOs

will provide and analyze paraffin blocks from a minimum number of

patients with specific tumor stages of breast, colorectal, or bladder

cancer and with a minimum number of years of clinical follow-up.  MA

Holders will perform evaluations of promising new diagnostic and

prognostic techniques as defined by individual MAOs.  Offerors may

qualify to perform one, all, or any combination of the following

methodologies: flow cytometry studies of cell proliferation, molecular

biology studies, and/or immunohistochemical assays.  Multiple MAOs may

be issued in each year.  The studies to be performed under the MAOs

will be designed by the NCI.  Publication of results of the studies is

expected to reflect the collaborative efforts between MAO Holders and

NCI staff.  This is the annual resolicitation of RFP Number



Requests for this solicitation must be in writing and reference MAA No.

NCI-CB-33050-60.  The Master Agreement Announcement (MAA) is now

available and responses will be due COB June 4, 1993.  Requests are to

be addressed to:

Barbara P. Birnman, Contract Specialist

Research Contracts Branch, CECS

National Cancer Institute

Executive Plaza South, Suite 620

Bethesda, MD  20892

Telephone:  (301) 496-8611


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