IN VITRO BIOGENIC AMINE RECEPTOR TESTING FOR POTENTIAL COCAINETREATMENT MEDICATIONS



NIH GUIDE, Volume 22, Number 11, March 19, 1993



RFP AVAILABLE:  NO1DA-3-8302



P.T. 34



Keywords:

  Receptors 

  Bioassay 

  Drugs/Drug Abuse 



National Institute on Drug Abuse



The National Institute on Drug Abuse (NIDA) is soliciting proposals

from qualified organizations having in-house capacity to perform in

vitro biogenic amine receptor assays to systematically define

biochemical activities of compounds at these targets.  These assays

will be utilized to characterize potential cocaine abuse treatment

agents.  The ability of these compounds to bind in vitro to

dopaminergic, serotoninergic, phencyclidine (PCP) and sigma binding

sites will be investigated.  The in vitro functional activity (i.e.

agonist, antagonist, partial agonist) of these compounds at dopamine

and serotonin sites will also be determined.  The offeror is required

to submit documentation of possession of a DEA Registration for

Schedules II-V controlled substances with their response to the Request

for Proposal (RFP).  In addition, the contractor must be able to obtain

a Schedule I DEA license.



It is estimated that the RFP will result in a three and one-half year

incrementally funded completion-type contract for a specific number of

compounds, with options for additional compound testing.  Estimated

issuance date of RFP No. NO1DA-3-8302 is March 22, 1993, and responses

are due to be received in the Contracting Office 45 calendar days

thereafter.  Requests for copies of solicitations will be honored if

received within twenty calendar days after issuance of the

solicitation.  Requests received after this period will be filled on a

first-come, first-served basis until the supply is exhausted.  However,

there is no assurance that copies requested after the twentieth day

will reach the requestor before the due date for receipt of responses.



INQUIRIES



Written requests are to be forwarded to:



Brenda Brooks, Contract Specialist

National Institute on Drug Abuse

Parklawn Building, Room 10-49

5600 Fishers Lane

Rockville, MD  20857



.

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