PREPARATION OF IMMUNOCONJUGATES NIH GUIDE, Volume 22, Number 9, March 5, 1993 MAA AVAILABLE: NCI-CM-37843-37 P.T. 34 Keywords: Cancer/Carcinogenesis National Cancer Institute Master Agreement Announcement (MAA) No. NCI-CM-37843-37, as published in the NIH Guide for Grants and Contracts, Vol. 22, No. 7, February 19, 1993, is amended to read as follows. This project was originally synopsized as a MAA No. NCI-CM-27731. The purpose of this procurement is to prepare preclinical and clinical grade monoclonal antibodies, antibody fragments, peptides, and/or other genetically engineered targeting molecules that are linked to chelating agents. The NCI will provide purified targeting molecules to the contractor for chemical conjugation to chelating agents using procedures that have either appeared in the peer reviewed literature or have been developed by the NCI. Proprietary technology developed by the offeror to prepare the desired immunoconjugates would prepare radioimmunoconjugates for both preclinical and clinical applications. All synthetic and purification procedures will be performed under Good Laboratory Procedures (GLP) and/or Good Manufacturing Practice (GMP). It is anticipated that the offeror will be required to prepare approximately 10-1000 mg of each immunoconjugate. The offeror will evaluate these immunoconjugates for purity, stability, immunoreactivity, and other criteria specified by the NCI. One or more awards may be made to qualified offerors responding to the RFP. INQUIRIES The amended MAA No. NCI-CM-37843-37 is now available and responses will be due on or about April 15, 1993. To obtain a copy of the Master Agreement Announcement, call or write: Patricia Lightner or Dorothy M. Coleman Treatment Contracts Section, Research Contracts Branch National Cancer Institute Executive Plaza South, Room 603 Bethesda, MD 20892 Telephone: (301) 496-8620 No collect calls will be accepted. .
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